Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

3FSL

Crystal structure of tyrosine aminotransferase tripple mutant (P181Q,R183G,A321K) from Escherichia coli at 2.35 A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004838molecular_functionL-tyrosine-2-oxoglutarate transaminase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006520biological_processamino acid metabolic process
A0006532biological_processaspartate biosynthetic process
A0006571biological_processtyrosine biosynthetic process
A0008483molecular_functiontransaminase activity
A0008652biological_processamino acid biosynthetic process
A0008793molecular_functionaromatic-amino-acid transaminase activity
A0009058biological_processbiosynthetic process
A0009073biological_processaromatic amino acid family biosynthetic process
A0009094biological_processL-phenylalanine biosynthetic process
A0009098biological_processL-leucine biosynthetic process
A0016740molecular_functiontransferase activity
A0019292biological_processL-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate
A0030170molecular_functionpyridoxal phosphate binding
A0033585biological_processL-phenylalanine biosynthetic process from chorismate via phenylpyruvate
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
B0003824molecular_functioncatalytic activity
B0004838molecular_functionL-tyrosine-2-oxoglutarate transaminase activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006520biological_processamino acid metabolic process
B0006532biological_processaspartate biosynthetic process
B0006571biological_processtyrosine biosynthetic process
B0008483molecular_functiontransaminase activity
B0008652biological_processamino acid biosynthetic process
B0008793molecular_functionaromatic-amino-acid transaminase activity
B0009058biological_processbiosynthetic process
B0009073biological_processaromatic amino acid family biosynthetic process
B0009094biological_processL-phenylalanine biosynthetic process
B0009098biological_processL-leucine biosynthetic process
B0016740molecular_functiontransferase activity
B0019292biological_processL-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate
B0030170molecular_functionpyridoxal phosphate binding
B0033585biological_processL-phenylalanine biosynthetic process from chorismate via phenylpyruvate
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
C0003824molecular_functioncatalytic activity
C0004838molecular_functionL-tyrosine-2-oxoglutarate transaminase activity
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006520biological_processamino acid metabolic process
C0006532biological_processaspartate biosynthetic process
C0006571biological_processtyrosine biosynthetic process
C0008483molecular_functiontransaminase activity
C0008652biological_processamino acid biosynthetic process
C0008793molecular_functionaromatic-amino-acid transaminase activity
C0009058biological_processbiosynthetic process
C0009073biological_processaromatic amino acid family biosynthetic process
C0009094biological_processL-phenylalanine biosynthetic process
C0009098biological_processL-leucine biosynthetic process
C0016740molecular_functiontransferase activity
C0019292biological_processL-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate
C0030170molecular_functionpyridoxal phosphate binding
C0033585biological_processL-phenylalanine biosynthetic process from chorismate via phenylpyruvate
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
D0003824molecular_functioncatalytic activity
D0004838molecular_functionL-tyrosine-2-oxoglutarate transaminase activity
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006520biological_processamino acid metabolic process
D0006532biological_processaspartate biosynthetic process
D0006571biological_processtyrosine biosynthetic process
D0008483molecular_functiontransaminase activity
D0008652biological_processamino acid biosynthetic process
D0008793molecular_functionaromatic-amino-acid transaminase activity
D0009058biological_processbiosynthetic process
D0009073biological_processaromatic amino acid family biosynthetic process
D0009094biological_processL-phenylalanine biosynthetic process
D0009098biological_processL-leucine biosynthetic process
D0016740molecular_functiontransferase activity
D0019292biological_processL-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate
D0030170molecular_functionpyridoxal phosphate binding
D0033585biological_processL-phenylalanine biosynthetic process from chorismate via phenylpyruvate
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
E0003824molecular_functioncatalytic activity
E0004838molecular_functionL-tyrosine-2-oxoglutarate transaminase activity
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006520biological_processamino acid metabolic process
E0006532biological_processaspartate biosynthetic process
E0006571biological_processtyrosine biosynthetic process
E0008483molecular_functiontransaminase activity
E0008652biological_processamino acid biosynthetic process
E0008793molecular_functionaromatic-amino-acid transaminase activity
E0009058biological_processbiosynthetic process
E0009073biological_processaromatic amino acid family biosynthetic process
E0009094biological_processL-phenylalanine biosynthetic process
E0009098biological_processL-leucine biosynthetic process
E0016740molecular_functiontransferase activity
E0019292biological_processL-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate
E0030170molecular_functionpyridoxal phosphate binding
E0033585biological_processL-phenylalanine biosynthetic process from chorismate via phenylpyruvate
E0042802molecular_functionidentical protein binding
E0042803molecular_functionprotein homodimerization activity
F0003824molecular_functioncatalytic activity
F0004838molecular_functionL-tyrosine-2-oxoglutarate transaminase activity
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006520biological_processamino acid metabolic process
F0006532biological_processaspartate biosynthetic process
F0006571biological_processtyrosine biosynthetic process
F0008483molecular_functiontransaminase activity
F0008652biological_processamino acid biosynthetic process
F0008793molecular_functionaromatic-amino-acid transaminase activity
F0009058biological_processbiosynthetic process
F0009073biological_processaromatic amino acid family biosynthetic process
F0009094biological_processL-phenylalanine biosynthetic process
F0009098biological_processL-leucine biosynthetic process
F0016740molecular_functiontransferase activity
F0019292biological_processL-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate
F0030170molecular_functionpyridoxal phosphate binding
F0033585biological_processL-phenylalanine biosynthetic process from chorismate via phenylpyruvate
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE PLR A 500
ChainResidue
AGLY107
ASER257
ALYS258
AARG266
BTYR70
AGLY108
ASER109
ATRP140
AASN194
AASP222
AALA224
ATYR225
ASER255

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE PLR B 500
ChainResidue
ATYR70
AHOH1063
BGLY107
BGLY108
BSER109
BTRP140
BASN194
BASP222
BALA224
BTYR225
BSER255
BSER257
BLYS258
BARG266

site_idAC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE PLR C 500
ChainResidue
AHOH1170
CGLY107
CGLY108
CSER109
CTRP140
CASN194
CASP222
CALA224
CTYR225
CSER255
CSER257
CLYS258
CARG266
DTYR70

site_idAC4
Number of Residues14
DetailsBINDING SITE FOR RESIDUE PLR D 500
ChainResidue
AHOH419
CTYR70
DGLY107
DGLY108
DSER109
DTRP140
DASN194
DASP222
DALA224
DTYR225
DSER255
DSER257
DLYS258
DARG266

site_idAC5
Number of Residues13
DetailsBINDING SITE FOR RESIDUE PLR E 500
ChainResidue
EGLY107
EGLY108
ESER109
ETRP140
EASN194
EASP222
EALA224
ETYR225
ESER255
ESER257
ELYS258
EARG266
FTYR70

site_idAC6
Number of Residues14
DetailsBINDING SITE FOR RESIDUE PLR F 500
ChainResidue
AHOH563
ETYR70
FGLY107
FGLY108
FSER109
FTRP140
FASN194
FASP222
FALA224
FTYR225
FSER255
FSER257
FLYS258
FARG266

Functional Information from PROSITE/UniProt
site_idPS00105
Number of Residues14
DetailsAA_TRANSFER_CLASS_1 Aminotransferases class-I pyridoxal-phosphate attachment site. SFSKifSLyGERVG
ChainResidueDetails
ASER255-GLY268

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues36
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsModified residue: {"description":"N6-(pyridoxal phosphate)lysine"}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
ATRP140
AASP222
ALYS258

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
BTRP140
BASP222
BLYS258

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
CTRP140
CASP222
CLYS258

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
DTRP140
DASP222
DLYS258

site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
ETRP140
EASP222
ELYS258

site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
FTRP140
FASP222
FLYS258

site_idCSA7
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
DTRP140
DASP222

site_idCSA8
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
ETRP140
EASP222

site_idCSA9
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
FTRP140
FASP222

239149

PDB entries from 2025-07-23

PDB statisticsPDBj update infoContact PDBjnumon