3EZ3
Crystal Structure of Plasmodium vivax geranylgeranylpyrophosphate synthase PVX_092040 with zoledronate and IPP bound
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004161 | molecular_function | dimethylallyltranstransferase activity |
A | 0004337 | molecular_function | geranyltranstransferase activity |
A | 0004659 | molecular_function | prenyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0008299 | biological_process | isoprenoid biosynthetic process |
A | 0016020 | cellular_component | membrane |
A | 0016740 | molecular_function | transferase activity |
A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
A | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
B | 0004161 | molecular_function | dimethylallyltranstransferase activity |
B | 0004337 | molecular_function | geranyltranstransferase activity |
B | 0004659 | molecular_function | prenyltransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0008299 | biological_process | isoprenoid biosynthetic process |
B | 0016020 | cellular_component | membrane |
B | 0016740 | molecular_function | transferase activity |
B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
B | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
B | 0046872 | molecular_function | metal ion binding |
C | 0004161 | molecular_function | dimethylallyltranstransferase activity |
C | 0004337 | molecular_function | geranyltranstransferase activity |
C | 0004659 | molecular_function | prenyltransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0008299 | biological_process | isoprenoid biosynthetic process |
C | 0016020 | cellular_component | membrane |
C | 0016740 | molecular_function | transferase activity |
C | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
C | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
C | 0046872 | molecular_function | metal ion binding |
D | 0004161 | molecular_function | dimethylallyltranstransferase activity |
D | 0004337 | molecular_function | geranyltranstransferase activity |
D | 0004659 | molecular_function | prenyltransferase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0008299 | biological_process | isoprenoid biosynthetic process |
D | 0016020 | cellular_component | membrane |
D | 0016740 | molecular_function | transferase activity |
D | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
D | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE ZOL A 397 |
Chain | Residue |
A | ASP126 |
A | IPE1101 |
A | MG1102 |
A | MG1103 |
A | MG1104 |
A | HOH1116 |
A | HOH1117 |
A | HOH1130 |
A | HOH1142 |
A | HOH1144 |
A | HOH1155 |
A | ASP130 |
A | HOH1162 |
A | HOH1164 |
A | HOH1251 |
A | ARG135 |
A | GLN195 |
A | LYS243 |
A | THR244 |
A | GLN284 |
A | ASP287 |
A | LYS301 |
site_id | AC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE IPE A1101 |
Chain | Residue |
A | GLY80 |
A | LYS81 |
A | ARG84 |
A | GLN119 |
A | ARG136 |
A | TYR247 |
A | PHE283 |
A | GLN284 |
A | ZOL397 |
A | HOH1118 |
A | HOH1119 |
A | HOH1167 |
A | HOH1190 |
A | HOH1206 |
A | HOH1250 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A1102 |
Chain | Residue |
A | ASP126 |
A | ASP130 |
A | ZOL397 |
A | MG1103 |
A | HOH1142 |
A | HOH1164 |
site_id | AC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE MG A1103 |
Chain | Residue |
A | ASP126 |
A | ASP130 |
A | ZOL397 |
A | MG1102 |
A | HOH1130 |
A | HOH1143 |
A | HOH1161 |
A | HOH1162 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A1104 |
Chain | Residue |
A | ASP287 |
A | ZOL397 |
A | HOH1116 |
A | HOH1144 |
A | HOH1251 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A1105 |
Chain | Residue |
A | GLU58 |
A | GLU60 |
A | ILE61 |
A | HOH1152 |
B | MET230 |
B | ASN232 |
B | VAL235 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A1106 |
Chain | Residue |
A | GLU133 |
A | TYR139 |
A | LEU143 |
B | ILE218 |
site_id | AC8 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE ZOL B 397 |
Chain | Residue |
B | ASP126 |
B | ASP130 |
B | ARG135 |
B | LYS243 |
B | THR244 |
B | GLN284 |
B | ASP287 |
B | LYS301 |
B | IPE1101 |
B | MG1102 |
B | MG1103 |
B | MG1104 |
B | EDO1106 |
B | HOH1135 |
B | HOH1144 |
B | HOH1149 |
B | HOH1164 |
B | HOH1187 |
B | HOH1261 |
site_id | AC9 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE IPE B1101 |
Chain | Residue |
B | GLY80 |
B | LYS81 |
B | ARG84 |
B | GLN119 |
B | ARG136 |
B | TYR247 |
B | PHE283 |
B | ZOL397 |
B | HOH1136 |
B | HOH1137 |
B | HOH1193 |
B | HOH1263 |
B | HOH1268 |
site_id | BC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG B1102 |
Chain | Residue |
B | ASP126 |
B | ASP130 |
B | ZOL397 |
B | MG1104 |
B | HOH1144 |
B | HOH1145 |
B | HOH1186 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG B1103 |
Chain | Residue |
B | ASP287 |
B | ZOL397 |
B | HOH1135 |
B | HOH1149 |
B | HOH1164 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B1104 |
Chain | Residue |
B | ASP126 |
B | ASP130 |
B | ZOL397 |
B | MG1102 |
B | HOH1162 |
B | HOH1187 |
site_id | BC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL B1105 |
Chain | Residue |
B | LEU290 |
B | ASP291 |
B | GLY294 |
B | SER296 |
B | THR299 |
B | LYS301 |
B | GLY303 |
B | EDO1106 |
site_id | BC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO B1106 |
Chain | Residue |
B | ASP291 |
B | LYS301 |
B | VAL302 |
B | GLY303 |
B | ZOL397 |
B | GOL1105 |
B | HOH1149 |
B | HOH1164 |
site_id | BC6 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE ZOL C 397 |
Chain | Residue |
C | ASP126 |
C | ASP130 |
C | ARG135 |
C | GLN195 |
C | LYS243 |
C | THR244 |
C | GLN284 |
C | ASP287 |
C | LYS301 |
C | IPE1101 |
C | MG1102 |
C | MG1103 |
C | MG1104 |
C | HOH1110 |
C | HOH1122 |
C | HOH1167 |
C | HOH1176 |
C | HOH1191 |
C | HOH1192 |
C | HOH1212 |
site_id | BC7 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE IPE C1101 |
Chain | Residue |
C | GLY80 |
C | LYS81 |
C | ARG84 |
C | GLN119 |
C | ARG136 |
C | TYR247 |
C | PHE283 |
C | GLN284 |
C | ZOL397 |
C | HOH1155 |
C | HOH1162 |
C | HOH1205 |
C | HOH1211 |
C | HOH1245 |
site_id | BC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C1102 |
Chain | Residue |
C | ASP126 |
C | ASP130 |
C | ZOL397 |
C | MG1103 |
C | HOH1118 |
C | HOH1192 |
site_id | BC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG C1103 |
Chain | Residue |
C | ASP126 |
C | ASP130 |
C | ZOL397 |
C | MG1102 |
C | HOH1120 |
C | HOH1122 |
C | HOH1175 |
site_id | CC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG C1104 |
Chain | Residue |
C | ASP287 |
C | ZOL397 |
C | HOH1110 |
C | HOH1167 |
C | HOH1191 |
site_id | CC2 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE ZOL D 397 |
Chain | Residue |
D | ASP126 |
D | ASP130 |
D | ARG135 |
D | LYS243 |
D | THR244 |
D | GLN284 |
D | ASP287 |
D | LYS301 |
D | IPE1101 |
D | MG1102 |
D | MG1103 |
D | MG1104 |
D | HOH1150 |
D | HOH1157 |
D | HOH1158 |
D | HOH1159 |
D | HOH1163 |
D | HOH1200 |
D | HOH1245 |
D | HOH1264 |
site_id | CC3 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE IPE D1101 |
Chain | Residue |
D | GLY80 |
D | LYS81 |
D | ARG84 |
D | GLN119 |
D | ARG136 |
D | TYR247 |
D | PHE283 |
D | GLN284 |
D | ZOL397 |
D | HOH1165 |
D | HOH1218 |
D | HOH1230 |
D | HOH1251 |
D | HOH1255 |
site_id | CC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG D1102 |
Chain | Residue |
D | ASP126 |
D | ASP130 |
D | ZOL397 |
D | MG1103 |
D | HOH1157 |
D | HOH1160 |
D | HOH1200 |
site_id | CC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG D1103 |
Chain | Residue |
D | ASP126 |
D | ASP130 |
D | ZOL397 |
D | MG1102 |
D | HOH1150 |
D | HOH1158 |
site_id | CC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG D1104 |
Chain | Residue |
D | ASP287 |
D | ZOL397 |
D | HOH1163 |
D | HOH1173 |
D | HOH1245 |
site_id | CC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL D1105 |
Chain | Residue |
B | LYS343 |
D | ASP291 |
D | ILE292 |
D | GLY303 |
D | ASP305 |
D | ILE306 |
D | ASP346 |
D | HOH1164 |
Functional Information from PROSITE/UniProt
site_id | PS00444 |
Number of Residues | 13 |
Details | POLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGeyFQIhDDYlD |
Chain | Residue | Details |
A | MET279-ASP291 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1fps |
Chain | Residue | Details |
A | ARG135 | |
A | PHE283 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1fps |
Chain | Residue | Details |
B | ARG135 | |
B | PHE283 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1fps |
Chain | Residue | Details |
C | ARG135 | |
C | PHE283 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1fps |
Chain | Residue | Details |
D | ARG135 | |
D | PHE283 |