3ERD
HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH DIETHYLSTILBESTROL AND A GLUCOCORTICOID RECEPTOR INTERACTING PROTEIN 1 NR BOX II PEPTIDE
Replaces: 2ERDFunctional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 601 |
| Chain | Residue |
| A | ARG352 |
| B | HOH45 |
| B | ARG352 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE DES A 600 |
| Chain | Residue |
| A | ARG394 |
| A | PHE404 |
| A | MET421 |
| A | GLY521 |
| A | HIS524 |
| A | LEU525 |
| A | MET528 |
| A | HOH11 |
| A | MET343 |
| A | ALA350 |
| A | GLU353 |
| A | LEU384 |
| A | LEU387 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DES B 800 |
| Chain | Residue |
| B | MET343 |
| B | ALA350 |
| B | GLU353 |
| B | ARG394 |
| B | PHE404 |
| B | MET421 |
| B | HIS524 |
| B | LEU525 |
| B | MET528 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACY B 717 |
| Chain | Residue |
| B | HOH123 |
| B | PRO336 |
| B | PHE337 |
| B | GLN414 |
| B | CYS417 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACY B 730 |
| Chain | Residue |
| A | LEU310 |
| A | LYS481 |
| B | CYS530 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE |
| Chain | Residue | Details |
| A | GLU353 | |
| A | ARG394 | |
| A | HIS524 | |
| B | GLU353 | |
| B | ARG394 | |
| B | HIS524 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 |
| Chain | Residue | Details |
| A | TYR537 | |
| B | TYR537 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 | |
| B | CYS447 |
