3ER9
Crystal structure of the heterodimeric vaccinia virus mRNA polyadenylate polymerase complex with UU and 3'-deoxy ATP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0004483 | molecular_function | methyltransferase cap1 activity |
| A | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| A | 0031440 | biological_process | regulation of mRNA 3'-end processing |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006397 | biological_process | mRNA processing |
| B | 0016740 | molecular_function | transferase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 1990817 | molecular_function | poly(A) RNA polymerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 3AT B 800 |
| Chain | Residue |
| B | SER188 |
| B | ARG308 |
| B | ASN402 |
| B | CA901 |
| B | HOH1066 |
| B | HOH1210 |
| B | HOH1235 |
| B | HOH1250 |
| B | HOH1298 |
| B | HOH1310 |
| B | GLY201 |
| B | ASP202 |
| B | ASP204 |
| B | GLN281 |
| B | ASN284 |
| B | MET288 |
| B | ARG294 |
| B | LYS304 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 901 |
| Chain | Residue |
| B | ASP202 |
| B | ASP204 |
| B | 3AT800 |
| B | HOH1066 |
| B | HOH1310 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 902 |
| Chain | Residue |
| B | ASP202 |
| B | ASP204 |
| B | HOH1308 |
| B | HOH1310 |
| B | HOH1311 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 880 |
| Chain | Residue |
| A | PHE251 |
| A | ASP252 |
| A | TYR264 |
| A | HOH1085 |
| A | HOH1306 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 890 |
| Chain | Residue |
| A | TYR77 |
| A | HIS81 |
| A | ASN84 |
| A | HOH1204 |
| A | HOH1303 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL A 900 |
| Chain | Residue |
| A | THR279 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | Region: {"description":"Binding to NPH-I"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For methyltransferase activity","evidences":[{"source":"PubMed","id":"15134442","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00944","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8612277","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PIRSR","id":"PIRSR015693-50","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16678106","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19446524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ERC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
