3EO3
Crystal structure of the N-acetylmannosamine kinase domain of human GNE protein
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 801 |
| Chain | Residue |
| A | HIS569 |
| A | CYS579 |
| A | CYS581 |
| A | CYS586 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 801 |
| Chain | Residue |
| B | HIS569 |
| B | CYS579 |
| B | CYS581 |
| B | CYS586 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 801 |
| Chain | Residue |
| C | CYS579 |
| C | CYS581 |
| C | CYS586 |
| C | HIS569 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 1 |
| Chain | Residue |
| A | HIS604 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX A 2 |
| Chain | Residue |
| A | ARG420 |
| A | ASP703 |
| A | ALA705 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX B 3 |
| Chain | Residue |
| B | PRO704 |
| B | ALA705 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX C 4 |
| Chain | Residue |
| C | GLU525 |
| C | GLY529 |
| C | GLN530 |
| C | ASP700 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:22343627, ECO:0007744|PDB:2YHW, ECO:0007744|PDB:2YHY |
| Chain | Residue | Details |
| A | ASP517 | |
| B | ASP517 | |
| C | ASP517 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22343627, ECO:0007744|PDB:2YHY, ECO:0007744|PDB:2YI1 |
| Chain | Residue | Details |
| A | ASP413 | |
| C | THR417 | |
| C | ASN418 | |
| C | ARG420 | |
| A | THR417 | |
| A | ASN418 | |
| A | ARG420 | |
| B | ASP413 | |
| B | THR417 | |
| B | ASN418 | |
| B | ARG420 | |
| C | ASP413 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22343627, ECO:0007744|PDB:2YI1 |
| Chain | Residue | Details |
| A | GLY416 | |
| B | GLY476 | |
| B | ARG477 | |
| B | THR489 | |
| B | ASN516 | |
| B | ASP517 | |
| B | GLY545 | |
| B | GLU588 | |
| C | GLY416 | |
| C | GLY476 | |
| C | ARG477 | |
| A | GLY476 | |
| C | THR489 | |
| C | ASN516 | |
| C | ASP517 | |
| C | GLY545 | |
| C | GLU588 | |
| A | ARG477 | |
| A | THR489 | |
| A | ASN516 | |
| A | ASP517 | |
| A | GLY545 | |
| A | GLU588 | |
| B | GLY416 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22343627, ECO:0007744|PDB:2YHW, ECO:0007744|PDB:2YHY, ECO:0007744|PDB:2YI1 |
| Chain | Residue | Details |
| A | GLU566 | |
| B | GLU566 | |
| C | GLU566 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19841673, ECO:0000269|PubMed:22343627, ECO:0007744|PDB:2YHW, ECO:0007744|PDB:2YHY, ECO:0007744|PDB:2YI1, ECO:0007744|PDB:3EO3 |
| Chain | Residue | Details |
| A | HIS569 | |
| C | CYS579 | |
| C | CYS581 | |
| C | CYS586 | |
| A | CYS579 | |
| A | CYS581 | |
| A | CYS586 | |
| B | HIS569 | |
| B | CYS579 | |
| B | CYS581 | |
| B | CYS586 | |
| C | HIS569 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q18 |
| Chain | Residue | Details |
| A | ASP517 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q18 |
| Chain | Residue | Details |
| B | ASP517 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q18 |
| Chain | Residue | Details |
| C | ASP517 |
