3EI4

Structure of the hsDDB1-hsDDB2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000109	cellular_component	nucleotide-excision repair complex
A	0000781	cellular_component	chromosome, telomeric region
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006281	biological_process	DNA repair
A	0006289	biological_process	nucleotide-excision repair
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006974	biological_process	DNA damage response
A	0007056	biological_process	spindle assembly involved in female meiosis
A	0007283	biological_process	spermatogenesis
A	0008283	biological_process	cell population proliferation
A	0010498	biological_process	proteasomal protein catabolic process
A	0010506	biological_process	regulation of autophagy
A	0016567	biological_process	protein ubiquitination
A	0019076	biological_process	viral release from host cell
A	0030174	biological_process	regulation of DNA-templated DNA replication initiation
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0031297	biological_process	replication fork processing
A	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
A	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
A	0032814	biological_process	regulation of natural killer cell activation
A	0032991	cellular_component	protein-containing complex
A	0034644	biological_process	cellular response to UV
A	0035861	cellular_component	site of double-strand break
A	0040029	biological_process	epigenetic regulation of gene expression
A	0042127	biological_process	regulation of cell population proliferation
A	0042752	biological_process	regulation of circadian rhythm
A	0042981	biological_process	regulation of apoptotic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0044725	biological_process	epigenetic programming in the zygotic pronuclei
A	0044877	molecular_function	protein-containing complex binding
A	0045070	biological_process	positive regulation of viral genome replication
A	0045722	biological_process	positive regulation of gluconeogenesis
A	0045732	biological_process	positive regulation of protein catabolic process
A	0045995	biological_process	regulation of embryonic development
A	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
A	0048511	biological_process	rhythmic process
A	0051702	biological_process	biological process involved in interaction with symbiont
A	0060964	biological_process	regulation of miRNA-mediated gene silencing
A	0070062	cellular_component	extracellular exosome
A	0070914	biological_process	UV-damage excision repair
A	0071987	molecular_function	WD40-repeat domain binding
A	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
A	0080135	biological_process	regulation of cellular response to stress
A	0097602	molecular_function	cullin family protein binding
A	0160072	molecular_function	ubiquitin ligase complex scaffold activity
A	1901987	biological_process	regulation of cell cycle phase transition
A	1901990	biological_process	regulation of mitotic cell cycle phase transition
A	1902412	biological_process	regulation of mitotic cytokinesis
A	1904178	biological_process	negative regulation of adipose tissue development
A	2000036	biological_process	regulation of stem cell population maintenance
B	0000209	biological_process	protein polyubiquitination
B	0000785	cellular_component	chromatin
B	0003677	molecular_function	DNA binding
B	0003684	molecular_function	damaged DNA binding
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006281	biological_process	DNA repair
B	0006289	biological_process	nucleotide-excision repair
B	0006974	biological_process	DNA damage response
B	0009411	biological_process	response to UV
B	0016567	biological_process	protein ubiquitination
B	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
B	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
B	0032991	cellular_component	protein-containing complex
B	0034644	biological_process	cellular response to UV
B	0044877	molecular_function	protein-containing complex binding
B	0051865	biological_process	protein autoubiquitination
B	0070914	biological_process	UV-damage excision repair
B	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
B	0090734	cellular_component	site of DNA damage
C	0000109	cellular_component	nucleotide-excision repair complex
C	0000781	cellular_component	chromosome, telomeric region
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0003684	molecular_function	damaged DNA binding
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0006281	biological_process	DNA repair
C	0006289	biological_process	nucleotide-excision repair
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006974	biological_process	DNA damage response
C	0007056	biological_process	spindle assembly involved in female meiosis
C	0007283	biological_process	spermatogenesis
C	0008283	biological_process	cell population proliferation
C	0010498	biological_process	proteasomal protein catabolic process
C	0010506	biological_process	regulation of autophagy
C	0016567	biological_process	protein ubiquitination
C	0019076	biological_process	viral release from host cell
C	0030174	biological_process	regulation of DNA-templated DNA replication initiation
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031297	biological_process	replication fork processing
C	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
C	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
C	0032814	biological_process	regulation of natural killer cell activation
C	0032991	cellular_component	protein-containing complex
C	0034644	biological_process	cellular response to UV
C	0035861	cellular_component	site of double-strand break
C	0040029	biological_process	epigenetic regulation of gene expression
C	0042127	biological_process	regulation of cell population proliferation
C	0042752	biological_process	regulation of circadian rhythm
C	0042981	biological_process	regulation of apoptotic process
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0044725	biological_process	epigenetic programming in the zygotic pronuclei
C	0044877	molecular_function	protein-containing complex binding
C	0045070	biological_process	positive regulation of viral genome replication
C	0045722	biological_process	positive regulation of gluconeogenesis
C	0045732	biological_process	positive regulation of protein catabolic process
C	0045995	biological_process	regulation of embryonic development
C	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
C	0048511	biological_process	rhythmic process
C	0051702	biological_process	biological process involved in interaction with symbiont
C	0060964	biological_process	regulation of miRNA-mediated gene silencing
C	0070062	cellular_component	extracellular exosome
C	0070914	biological_process	UV-damage excision repair
C	0071987	molecular_function	WD40-repeat domain binding
C	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
C	0080135	biological_process	regulation of cellular response to stress
C	0097602	molecular_function	cullin family protein binding
C	0160072	molecular_function	ubiquitin ligase complex scaffold activity
C	1901987	biological_process	regulation of cell cycle phase transition
C	1901990	biological_process	regulation of mitotic cell cycle phase transition
C	1902412	biological_process	regulation of mitotic cytokinesis
C	1904178	biological_process	negative regulation of adipose tissue development
C	2000036	biological_process	regulation of stem cell population maintenance
D	0000209	biological_process	protein polyubiquitination
D	0000785	cellular_component	chromatin
D	0003677	molecular_function	DNA binding
D	0003684	molecular_function	damaged DNA binding
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0006281	biological_process	DNA repair
D	0006289	biological_process	nucleotide-excision repair
D	0006974	biological_process	DNA damage response
D	0009411	biological_process	response to UV
D	0016567	biological_process	protein ubiquitination
D	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
D	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
D	0032991	cellular_component	protein-containing complex
D	0034644	biological_process	cellular response to UV
D	0044877	molecular_function	protein-containing complex binding
D	0051865	biological_process	protein autoubiquitination
D	0070914	biological_process	UV-damage excision repair
D	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
D	0090734	cellular_component	site of DNA damage
E	0000109	cellular_component	nucleotide-excision repair complex
E	0000781	cellular_component	chromosome, telomeric region
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0003684	molecular_function	damaged DNA binding
E	0005515	molecular_function	protein binding
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0006281	biological_process	DNA repair
E	0006289	biological_process	nucleotide-excision repair
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006974	biological_process	DNA damage response
E	0007056	biological_process	spindle assembly involved in female meiosis
E	0007283	biological_process	spermatogenesis
E	0008283	biological_process	cell population proliferation
E	0010498	biological_process	proteasomal protein catabolic process
E	0010506	biological_process	regulation of autophagy
E	0016567	biological_process	protein ubiquitination
E	0019076	biological_process	viral release from host cell
E	0030174	biological_process	regulation of DNA-templated DNA replication initiation
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0031297	biological_process	replication fork processing
E	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
E	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
E	0032814	biological_process	regulation of natural killer cell activation
E	0032991	cellular_component	protein-containing complex
E	0034644	biological_process	cellular response to UV
E	0035861	cellular_component	site of double-strand break
E	0040029	biological_process	epigenetic regulation of gene expression
E	0042127	biological_process	regulation of cell population proliferation
E	0042752	biological_process	regulation of circadian rhythm
E	0042981	biological_process	regulation of apoptotic process
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0044725	biological_process	epigenetic programming in the zygotic pronuclei
E	0044877	molecular_function	protein-containing complex binding
E	0045070	biological_process	positive regulation of viral genome replication
E	0045722	biological_process	positive regulation of gluconeogenesis
E	0045732	biological_process	positive regulation of protein catabolic process
E	0045995	biological_process	regulation of embryonic development
E	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
E	0048511	biological_process	rhythmic process
E	0051702	biological_process	biological process involved in interaction with symbiont
E	0060964	biological_process	regulation of miRNA-mediated gene silencing
E	0070062	cellular_component	extracellular exosome
E	0070914	biological_process	UV-damage excision repair
E	0071987	molecular_function	WD40-repeat domain binding
E	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
E	0080135	biological_process	regulation of cellular response to stress
E	0097602	molecular_function	cullin family protein binding
E	0160072	molecular_function	ubiquitin ligase complex scaffold activity
E	1901987	biological_process	regulation of cell cycle phase transition
E	1901990	biological_process	regulation of mitotic cell cycle phase transition
E	1902412	biological_process	regulation of mitotic cytokinesis
E	1904178	biological_process	negative regulation of adipose tissue development
E	2000036	biological_process	regulation of stem cell population maintenance
F	0000209	biological_process	protein polyubiquitination
F	0000785	cellular_component	chromatin
F	0003677	molecular_function	DNA binding
F	0003684	molecular_function	damaged DNA binding
F	0004842	molecular_function	ubiquitin-protein transferase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0006281	biological_process	DNA repair
F	0006289	biological_process	nucleotide-excision repair
F	0006974	biological_process	DNA damage response
F	0009411	biological_process	response to UV
F	0016567	biological_process	protein ubiquitination
F	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
F	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
F	0032991	cellular_component	protein-containing complex
F	0034644	biological_process	cellular response to UV
F	0044877	molecular_function	protein-containing complex binding
F	0051865	biological_process	protein autoubiquitination
F	0070914	biological_process	UV-damage excision repair
F	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
F	0090734	cellular_component	site of DNA damage

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATAsvDqTVKIWDL

Chain	Residue	Details
B	LEU258-LEU272

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2298
Details	Region: {"description":"Interaction with CDT1","evidences":[{"source":"PubMed","id":"15448697","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1029
Details	Region: {"description":"WD repeat beta-propeller A"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	948
Details	Region: {"description":"WD repeat beta-propeller B; Interaction with CUL4A"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1002
Details	Region: {"description":"WD repeat beta-propeller C"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1107
Details	Region: {"description":"Interaction with CDT1 and CUL4A","evidences":[{"source":"PubMed","id":"15448697","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	105
Details	Repeat: {"description":"WD 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19109893","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	105
Details	Repeat: {"description":"WD 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19109893","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	105
Details	Repeat: {"description":"WD 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19109893","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	129
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19109893","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	117
Details	Repeat: {"description":"WD 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19109893","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	129
Details	Repeat: {"description":"WD 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19109893","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	72
Details	Repeat: {"description":"WD 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19109893","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	66
Details	Region: {"description":"Required for interaction with DDB1","evidences":[{"source":"PubMed","id":"9632823","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	6
Details	Region: {"description":"Photolesion recognition"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	54
Details	Motif: {"description":"DWD box","evidences":[{"source":"PubMed","id":"17079684","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"32789493","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---