3EE2

Structure of human prostaglandin D-synthase (hGSTS1-1) in complex with nocodazole

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0001516	biological_process	prostaglandin biosynthetic process
A	0004364	molecular_function	glutathione transferase activity
A	0004667	molecular_function	prostaglandin-D synthase activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006693	biological_process	prostaglandin metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0007165	biological_process	signal transduction
A	0007626	biological_process	locomotory behavior
A	0009624	biological_process	response to nematode
A	0010269	biological_process	response to selenium ion
A	0016740	molecular_function	transferase activity
A	0016853	molecular_function	isomerase activity
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
A	2000255	biological_process	negative regulation of male germ cell proliferation
B	0000287	molecular_function	magnesium ion binding
B	0001516	biological_process	prostaglandin biosynthetic process
B	0004364	molecular_function	glutathione transferase activity
B	0004667	molecular_function	prostaglandin-D synthase activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0006693	biological_process	prostaglandin metabolic process
B	0006749	biological_process	glutathione metabolic process
B	0007165	biological_process	signal transduction
B	0007626	biological_process	locomotory behavior
B	0009624	biological_process	response to nematode
B	0010269	biological_process	response to selenium ion
B	0016740	molecular_function	transferase activity
B	0016853	molecular_function	isomerase activity
B	0042803	molecular_function	protein homodimerization activity
B	0046872	molecular_function	metal ion binding
B	2000255	biological_process	negative regulation of male germ cell proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GSH A 200

Chain	Residue
A	TYR8
A	NZO201
A	HOH209
B	ASP97
B	GLN196
A	ARG14
A	TRP39
A	LYS43
A	LYS50
A	ILE51
A	PRO52
A	GLN63
A	SER64

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NZO A 201

Chain	Residue
A	ARG14
A	ASP96
A	MET99
A	TRP104
A	TYR152
A	THR159
A	LEU199
A	GSH200
A	HOH295

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG B 300

Chain	Residue
B	ASP96
B	HOH301
B	HOH302
B	HOH303
B	HOH369
B	HOH370
B	HOH371

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	154
Details	Domain: {"description":"GST N-terminal"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	236
Details	Domain: {"description":"GST C-terminal"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12627223","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15113825","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16547010","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18341273","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19939518","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
A	TYR8

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
B	TYR8

---