3ECR
Structure of human porphobilinogen deaminase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004418 | molecular_function | hydroxymethylbilane synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| A | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| A | 0006783 | biological_process | heme biosynthetic process |
| A | 0006784 | biological_process | heme A biosynthetic process |
| A | 0006785 | biological_process | heme B biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018160 | biological_process | peptidyl-pyrromethane cofactor linkage |
| A | 0033014 | biological_process | tetrapyrrole biosynthetic process |
| B | 0004418 | molecular_function | hydroxymethylbilane synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| B | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| B | 0006783 | biological_process | heme biosynthetic process |
| B | 0006784 | biological_process | heme A biosynthetic process |
| B | 0006785 | biological_process | heme B biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0018160 | biological_process | peptidyl-pyrromethane cofactor linkage |
| B | 0033014 | biological_process | tetrapyrrole biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE DPM A 365 |
| Chain | Residue |
| A | SER99 |
| A | LEU191 |
| A | ALA192 |
| A | GLN220 |
| A | GLY221 |
| A | CYS264 |
| A | HOH366 |
| A | LYS101 |
| A | ASP102 |
| A | THR148 |
| A | SER149 |
| A | SER150 |
| A | ARG152 |
| A | ARG153 |
| A | ARG176 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE DPM B 365 |
| Chain | Residue |
| B | ILE74 |
| B | SER99 |
| B | LYS101 |
| B | ASP102 |
| B | SER149 |
| B | SER150 |
| B | ARG152 |
| B | ARG153 |
| B | ARG176 |
| B | LEU191 |
| B | ALA192 |
| B | GLN220 |
| B | GLY221 |
| B | CYS264 |
| B | HOH370 |
| B | HOH371 |
| B | HOH385 |
| B | HOH401 |
| B | HOH410 |
Functional Information from PROSITE/UniProt
| site_id | PS00533 |
| Number of Residues | 17 |
| Details | PORPHOBILINOGEN_DEAM Porphobilinogen deaminase cofactor-binding site. ERaFlrhLeGGCsVPVA |
| Chain | Residue | Details |
| A | GLU253-ALA269 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-(dipyrrolylmethanemethyl)cysteine","evidences":[{"source":"PubMed","id":"18936296","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P22907","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 2ypn |
| Chain | Residue | Details |
| A | CYS264 | |
| A | ASP102 | |
| A | ARG152 | |
| A | ARG170 | |
| A | ARG153 | |
| A | ARG176 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 2ypn |
| Chain | Residue | Details |
| B | CYS264 | |
| B | ASP102 | |
| B | ARG152 | |
| B | ARG170 | |
| B | ARG153 | |
| B | ARG176 |
