3E0Q
Crystal structure of Schistosoma mansoni purine nucleoside phosphorylase complexed with a novel monocyclic inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0047975 | molecular_function | guanosine phosphorylase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0047975 | molecular_function | guanosine phosphorylase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0047975 | molecular_function | guanosine phosphorylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 300 |
| Chain | Residue |
| A | ASN95 |
| A | ALA99 |
| A | ARG103 |
| A | ILE148 |
| A | GLN154 |
| A | HOH528 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 301 |
| Chain | Residue |
| C | LEU140 |
| C | GLY144 |
| A | LEU140 |
| A | HOH420 |
| B | GLY144 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE JFD A 400 |
| Chain | Residue |
| A | ALA118 |
| A | GLY120 |
| A | TYR202 |
| A | GLU203 |
| A | GLY220 |
| A | MET221 |
| A | THR244 |
| A | ASN245 |
| A | HOH455 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS B 302 |
| Chain | Residue |
| B | ASN95 |
| B | ALA99 |
| B | ARG103 |
| B | ILE148 |
| B | GLN154 |
| B | HOH490 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE JFD B 401 |
| Chain | Residue |
| B | GLY120 |
| B | TYR202 |
| B | GLU203 |
| B | GLY220 |
| B | MET221 |
| B | THR244 |
| B | ASN245 |
| B | HOH474 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS C 303 |
| Chain | Residue |
| C | ASN95 |
| C | ALA99 |
| C | ARG103 |
| C | ILE148 |
| C | GLN154 |
| C | HOH457 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE JFD C 402 |
| Chain | Residue |
| C | ALA118 |
| C | GLY120 |
| C | TYR202 |
| C | GLU203 |
| C | GLY220 |
| C | MET221 |
| C | THR244 |
| C | ASN245 |
| C | HOH437 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ula |
| Chain | Residue | Details |
| A | ASN245 | |
| A | HIS88 | |
| A | GLU91 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ula |
| Chain | Residue | Details |
| B | ASN245 | |
| B | HIS88 | |
| B | GLU91 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ula |
| Chain | Residue | Details |
| C | ASN245 | |
| C | HIS88 | |
| C | GLU91 |
