3DNF
Structure of (E)-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate Pathway
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016114 | biological_process | terpenoid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050992 | biological_process | dimethylallyl diphosphate biosynthetic process |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| A | 0051745 | molecular_function | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016114 | biological_process | terpenoid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050992 | biological_process | dimethylallyl diphosphate biosynthetic process |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| B | 0051745 | molecular_function | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE F3S A 2302 |
| Chain | Residue |
| A | CYS13 |
| A | GLY15 |
| A | CYS96 |
| A | TYR98 |
| A | THR165 |
| A | CYS193 |
| A | ALA195 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE F3S B 3302 |
| Chain | Residue |
| B | CYS96 |
| B | THR165 |
| B | CYS193 |
| B | ALA195 |
| B | CYS13 |
| B | GLY15 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 3731 |
| Chain | Residue |
| A | GLY113 |
| A | LYS140 |
| A | HIS156 |
| A | GLU157 |
| A | ARG158 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 3732 |
| Chain | Residue |
| B | GLY113 |
| B | LYS140 |
| B | HIS156 |
| B | GLU157 |
| B | ARG158 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00191 |
| Chain | Residue | Details |
| A | GLU126 | |
| B | GLU126 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00191, ECO:0000305|PubMed:19035630 |
| Chain | Residue | Details |
| A | CYS13 | |
| A | CYS96 | |
| A | CYS193 | |
| B | CYS13 | |
| B | CYS96 | |
| B | CYS193 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00191 |
| Chain | Residue | Details |
| A | HIS42 | |
| B | THR165 | |
| B | SER221 | |
| B | SER265 | |
| A | HIS74 | |
| A | HIS124 | |
| A | THR165 | |
| A | SER221 | |
| A | SER265 | |
| B | HIS42 | |
| B | HIS74 | |
| B | HIS124 |
