Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

3C7K

Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0006904biological_processvesicle docking involved in exocytosis
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
A0007212biological_processG protein-coupled dopamine receptor signaling pathway
A0007626biological_processlocomotory behavior
A0008016biological_processregulation of heart contraction
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019001molecular_functionguanyl nucleotide binding
A0030425cellular_componentdendrite
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0031852molecular_functionmu-type opioid receptor binding
A0042734cellular_componentpresynaptic membrane
A0043209cellular_componentmyelin sheath
A0044297cellular_componentcell body
A0045211cellular_componentpostsynaptic membrane
A0046676biological_processnegative regulation of insulin secretion
A0046872molecular_functionmetal ion binding
A0051430molecular_functioncorticotropin-releasing hormone receptor 1 binding
A0071867biological_processresponse to monoamine
A0098688cellular_componentparallel fiber to Purkinje cell synapse
A0098978cellular_componentglutamatergic synapse
A0098982cellular_componentGABA-ergic synapse
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
C0000166molecular_functionnucleotide binding
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0006904biological_processvesicle docking involved in exocytosis
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
C0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
C0007212biological_processG protein-coupled dopamine receptor signaling pathway
C0007626biological_processlocomotory behavior
C0008016biological_processregulation of heart contraction
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0019001molecular_functionguanyl nucleotide binding
C0030425cellular_componentdendrite
C0031683molecular_functionG-protein beta/gamma-subunit complex binding
C0031821molecular_functionG protein-coupled serotonin receptor binding
C0031852molecular_functionmu-type opioid receptor binding
C0042734cellular_componentpresynaptic membrane
C0043209cellular_componentmyelin sheath
C0044297cellular_componentcell body
C0045211cellular_componentpostsynaptic membrane
C0046676biological_processnegative regulation of insulin secretion
C0046872molecular_functionmetal ion binding
C0051430molecular_functioncorticotropin-releasing hormone receptor 1 binding
C0071867biological_processresponse to monoamine
C0098688cellular_componentparallel fiber to Purkinje cell synapse
C0098978cellular_componentglutamatergic synapse
C0098982cellular_componentGABA-ergic synapse
C0099170biological_processpostsynaptic modulation of chemical synaptic transmission
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG A 362
ChainResidue
ASER47
ATHR182

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE ALF A 365
ChainResidue
AGLY204
AGLN205
AALA41
AGLY42
AGLU43
ALYS46
AARG179
ALYS181
ATHR182

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG C 362
ChainResidue
CSER47
CTHR182

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ALF C 365
ChainResidue
CGLY42
CGLU43
CLYS46
CARG179
CLYS181
CTHR182
CGLY204
CGLN205

site_idAC5
Number of Residues19
DetailsBINDING SITE FOR RESIDUE GDP A 361
ChainResidue
AGLU43
ASER44
AGLY45
ALYS46
ASER47
ATHR48
AASP151
ASER152
ALEU176
AARG177
ATHR178
AARG179
AASN270
ALYS271
AASP273
ALEU274
ACYS325
AALA326
ATHR327

site_idAC6
Number of Residues18
DetailsBINDING SITE FOR RESIDUE GDP C 361
ChainResidue
CGLU43
CSER44
CGLY45
CLYS46
CSER47
CTHR48
CASP151
CSER152
CLEU176
CARG177
CTHR178
CARG179
CASN270
CLYS271
CASP273
CLEU274
CCYS325
CALA326

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by EGFR => ECO:0000250|UniProtKB:O15492
ChainResidueDetails
BTYR167
AASP273
ACYS325
CGLU43
CLYS46
CTHR48
CSER152
CLEU176
CARG177
CTHR178
CARG179
DTYR167
CASN270
CASP273
CCYS325
ATHR48
ASER152
ALEU176
AARG177
ATHR178
AARG179
AASN270

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:O15492
ChainResidueDetails
BTYR176
DTYR176
CSER47
CTHR182

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: 5-glutamyl histamine => ECO:0000269|PubMed:23022564
ChainResidueDetails
AGLN205
CGLN205

site_idSWS_FT_FI4
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P09471
ChainResidueDetails
ACYS351
CCYS351

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AARG179
ATHR182
AGLU43
AGLN205

site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
CARG179
CTHR182
CGLU43
CGLN205

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN205

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
CGLN205

238268

PDB entries from 2025-07-02

PDB statisticsPDBj update infoContact PDBjnumon