3BSQ
Crystal structure of human kallikrein 7 produced as a secretion protein in E.coli
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001533 | cellular_component | cornified envelope |
| A | 0002780 | biological_process | antibacterial peptide biosynthetic process |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0008544 | biological_process | epidermis development |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0022617 | biological_process | extracellular matrix disassembly |
| A | 0030141 | cellular_component | secretory granule |
| A | 0051604 | biological_process | protein maturation |
| A | 0097209 | cellular_component | epidermal lamellar body |
| B | 0001533 | cellular_component | cornified envelope |
| B | 0002780 | biological_process | antibacterial peptide biosynthetic process |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0008544 | biological_process | epidermis development |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0022617 | biological_process | extracellular matrix disassembly |
| B | 0030141 | cellular_component | secretory granule |
| B | 0051604 | biological_process | protein maturation |
| B | 0097209 | cellular_component | epidermal lamellar body |
| C | 0001533 | cellular_component | cornified envelope |
| C | 0002780 | biological_process | antibacterial peptide biosynthetic process |
| C | 0004222 | molecular_function | metalloendopeptidase activity |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0008544 | biological_process | epidermis development |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0022617 | biological_process | extracellular matrix disassembly |
| C | 0030141 | cellular_component | secretory granule |
| C | 0051604 | biological_process | protein maturation |
| C | 0097209 | cellular_component | epidermal lamellar body |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1 |
| Chain | Residue |
| A | LYS58 |
| A | SER84 |
| A | ARG86 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 5 |
| Chain | Residue |
| A | HIS56 |
| A | ASN188 |
| A | GLY189 |
| A | SER191 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 7 |
| Chain | Residue |
| A | GLY199 |
| A | THR200 |
| A | TRP29 |
| A | ARG118 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 8 |
| Chain | Residue |
| A | PRO159 |
| A | ASN172 |
| A | LYS226 |
| C | GLN38 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 9 |
| Chain | Residue |
| A | LYS58 |
| A | SER82 |
| A | LYS83 |
| A | SER84 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 13 |
| Chain | Residue |
| A | SER91 |
| A | THR92 |
| A | GLN93 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2 |
| Chain | Residue |
| B | SO411 |
| B | LYS58 |
| B | SER84 |
| B | PHE85 |
| B | ARG86 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 10 |
| Chain | Residue |
| B | SO415 |
| B | HIS56 |
| B | ASN188 |
| B | GLY189 |
| B | SER191 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 11 |
| Chain | Residue |
| B | SO42 |
| B | LYS58 |
| B | SER82 |
| B | SER84 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 12 |
| Chain | Residue |
| B | ARG49 |
| B | SER106 |
| B | GLN107 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 14 |
| Chain | Residue |
| B | GLN93 |
| B | THR94 |
| B | HIS95 |
| B | LEU169 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 15 |
| Chain | Residue |
| B | SO410 |
| B | ALA186 |
| B | CYS187 |
| B | ASN188 |
| B | GLY208 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 3 |
| Chain | Residue |
| C | LYS58 |
| C | SER84 |
| C | PHE85 |
| C | ARG86 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 4 |
| Chain | Residue |
| C | LYS58 |
| C | LYS83 |
| C | SER84 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 6 |
| Chain | Residue |
| C | HIS56 |
| C | ASN188 |
| C | GLY189 |
| C | SER191 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 239 |
| Chain | Residue |
| C | LYS83 |
| C | PHE85 |
| C | HIS237 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 440 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"17909180","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Site: {"description":"Major binding site for inhibitory zinc or copper"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP98 | |
| A | HIS56 | |
| A | SER191 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY189 | |
| A | SER191 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | GLY189 | |
| B | SER191 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | GLY189 | |
| C | SER191 |
| site_id | CSA13 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY192 | |
| A | SER191 |
| site_id | CSA14 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | GLY192 | |
| B | SER191 |
| site_id | CSA15 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | GLY192 | |
| C | SER191 |
| site_id | CSA16 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP98 | |
| A | GLY189 | |
| A | HIS56 | |
| A | SER191 |
| site_id | CSA17 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP98 | |
| B | GLY189 | |
| B | HIS56 | |
| B | SER191 |
| site_id | CSA18 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | ASP98 | |
| C | GLY189 | |
| C | HIS56 | |
| C | SER191 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP98 | |
| B | HIS56 | |
| B | SER191 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | ASP98 | |
| C | HIS56 | |
| C | SER191 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY192 | |
| A | ASP98 | |
| A | HIS56 | |
| A | SER191 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | GLY192 | |
| B | ASP98 | |
| B | HIS56 | |
| B | SER191 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | GLY192 | |
| C | ASP98 | |
| C | HIS56 | |
| C | SER191 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP98 | |
| A | HIS56 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP98 | |
| B | HIS56 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | ASP98 | |
| C | HIS56 |
