3B2Z
Crystal Structure of ADAMTS4 (apo form)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| C | 0004222 | molecular_function | metalloendopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008237 | molecular_function | metallopeptidase activity |
| D | 0004222 | molecular_function | metalloendopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008237 | molecular_function | metallopeptidase activity |
| E | 0004222 | molecular_function | metalloendopeptidase activity |
| E | 0006508 | biological_process | proteolysis |
| E | 0008237 | molecular_function | metallopeptidase activity |
| F | 0004222 | molecular_function | metalloendopeptidase activity |
| F | 0006508 | biological_process | proteolysis |
| F | 0008237 | molecular_function | metallopeptidase activity |
| G | 0004222 | molecular_function | metalloendopeptidase activity |
| G | 0006508 | biological_process | proteolysis |
| G | 0008237 | molecular_function | metallopeptidase activity |
| H | 0004222 | molecular_function | metalloendopeptidase activity |
| H | 0006508 | biological_process | proteolysis |
| H | 0008237 | molecular_function | metallopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1 |
| Chain | Residue |
| A | ASP328 |
| A | HIS361 |
| A | HIS365 |
| A | HIS371 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 2 |
| Chain | Residue |
| A | HOH532 |
| A | GLU221 |
| A | ASP304 |
| A | ASP311 |
| A | CYS423 |
| A | ASP426 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 3 |
| Chain | Residue |
| A | GLU221 |
| A | ASP304 |
| A | ASP426 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1 |
| Chain | Residue |
| B | ASP328 |
| B | HIS361 |
| B | HIS365 |
| B | HIS371 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 2 |
| Chain | Residue |
| B | CA3 |
| B | GLU221 |
| B | ASP311 |
| B | CYS423 |
| B | ASP426 |
| B | HOH510 |
| B | HOH515 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 3 |
| Chain | Residue |
| B | CA2 |
| B | GLU221 |
| B | ASP304 |
| B | ASP426 |
| B | HOH510 |
| B | HOH532 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1 |
| Chain | Residue |
| C | ASP328 |
| C | HIS361 |
| C | HIS365 |
| C | HIS371 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 2 |
| Chain | Residue |
| C | GLU221 |
| C | ASP304 |
| C | ASP311 |
| C | CYS423 |
| C | ASP426 |
| C | HOH516 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA C 3 |
| Chain | Residue |
| C | GLU221 |
| C | ASP304 |
| C | ASP426 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1 |
| Chain | Residue |
| D | ASP328 |
| D | HIS361 |
| D | HIS365 |
| D | HIS371 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 2 |
| Chain | Residue |
| D | GLU221 |
| D | ASP304 |
| D | ASP311 |
| D | CYS423 |
| D | ASP426 |
| D | HOH518 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA D 3 |
| Chain | Residue |
| D | GLU221 |
| D | ASP304 |
| D | ASP426 |
| D | HOH558 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 1 |
| Chain | Residue |
| E | ASP328 |
| E | HIS361 |
| E | HIS365 |
| E | HIS371 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA E 2 |
| Chain | Residue |
| E | GLU221 |
| E | ASP304 |
| E | ASP311 |
| E | CYS423 |
| E | ASP426 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA E 3 |
| Chain | Residue |
| E | GLU221 |
| E | ASP304 |
| E | ASP426 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 1 |
| Chain | Residue |
| F | ASP328 |
| F | HIS361 |
| F | HIS365 |
| F | HIS371 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA F 2 |
| Chain | Residue |
| F | GLU221 |
| F | ASP304 |
| F | ASP311 |
| F | CYS423 |
| F | ASP426 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA F 3 |
| Chain | Residue |
| F | GLU221 |
| F | ASP304 |
| F | ASP426 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN G 1 |
| Chain | Residue |
| G | ASP328 |
| G | HIS361 |
| G | HIS365 |
| G | HIS371 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA G 2 |
| Chain | Residue |
| G | GLU221 |
| G | ASP304 |
| G | ASP311 |
| G | CYS423 |
| G | ASP426 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA G 3 |
| Chain | Residue |
| G | GLU221 |
| G | ASP304 |
| G | ASP426 |
| G | HOH521 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN H 1 |
| Chain | Residue |
| H | ASP328 |
| H | HIS361 |
| H | HIS365 |
| H | HIS371 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA H 2 |
| Chain | Residue |
| H | ASP304 |
| H | ASP311 |
| H | CYS423 |
| H | ASP426 |
| H | HOH524 |
| H | GLU221 |
| site_id | CC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA H 3 |
| Chain | Residue |
| H | GLU221 |
| H | ASP304 |
| H | ASP426 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 |
| Chain | Residue | Details |
| A | GLN362 | |
| B | GLN362 | |
| C | GLN362 | |
| D | GLN362 | |
| E | GLN362 | |
| F | GLN362 | |
| G | GLN362 | |
| H | GLN362 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18042673 |
| Chain | Residue | Details |
| A | HIS361 | |
| D | HIS361 | |
| D | HIS365 | |
| D | HIS371 | |
| E | HIS361 | |
| E | HIS365 | |
| E | HIS371 | |
| F | HIS361 | |
| F | HIS365 | |
| F | HIS371 | |
| G | HIS361 | |
| A | HIS365 | |
| G | HIS365 | |
| G | HIS371 | |
| H | HIS361 | |
| H | HIS365 | |
| H | HIS371 | |
| A | HIS371 | |
| B | HIS361 | |
| B | HIS365 | |
| B | HIS371 | |
| C | HIS361 | |
| C | HIS365 | |
| C | HIS371 |
