Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3B2Z

Crystal Structure of ADAMTS4 (apo form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008237	molecular_function	metallopeptidase activity
C	0004222	molecular_function	metalloendopeptidase activity
C	0006508	biological_process	proteolysis
C	0008237	molecular_function	metallopeptidase activity
D	0004222	molecular_function	metalloendopeptidase activity
D	0006508	biological_process	proteolysis
D	0008237	molecular_function	metallopeptidase activity
E	0004222	molecular_function	metalloendopeptidase activity
E	0006508	biological_process	proteolysis
E	0008237	molecular_function	metallopeptidase activity
F	0004222	molecular_function	metalloendopeptidase activity
F	0006508	biological_process	proteolysis
F	0008237	molecular_function	metallopeptidase activity
G	0004222	molecular_function	metalloendopeptidase activity
G	0006508	biological_process	proteolysis
G	0008237	molecular_function	metallopeptidase activity
H	0004222	molecular_function	metalloendopeptidase activity
H	0006508	biological_process	proteolysis
H	0008237	molecular_function	metallopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	ASP328
A	HIS361
A	HIS365
A	HIS371

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 2

Chain	Residue
A	HOH532
A	GLU221
A	ASP304
A	ASP311
A	CYS423
A	ASP426

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 3

Chain	Residue
A	GLU221
A	ASP304
A	ASP426

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1

Chain	Residue
B	ASP328
B	HIS361
B	HIS365
B	HIS371

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA B 2

Chain	Residue
B	CA3
B	GLU221
B	ASP311
B	CYS423
B	ASP426
B	HOH510
B	HOH515

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 3

Chain	Residue
B	CA2
B	GLU221
B	ASP304
B	ASP426
B	HOH510
B	HOH532

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1

Chain	Residue
C	ASP328
C	HIS361
C	HIS365
C	HIS371

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 2

Chain	Residue
C	GLU221
C	ASP304
C	ASP311
C	CYS423
C	ASP426
C	HOH516

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA C 3

Chain	Residue
C	GLU221
C	ASP304
C	ASP426

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1

Chain	Residue
D	ASP328
D	HIS361
D	HIS365
D	HIS371

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 2

Chain	Residue
D	GLU221
D	ASP304
D	ASP311
D	CYS423
D	ASP426
D	HOH518

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA D 3

Chain	Residue
D	GLU221
D	ASP304
D	ASP426
D	HOH558

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 1

Chain	Residue
E	ASP328
E	HIS361
E	HIS365
E	HIS371

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA E 2

Chain	Residue
E	GLU221
E	ASP304
E	ASP311
E	CYS423
E	ASP426

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA E 3

Chain	Residue
E	GLU221
E	ASP304
E	ASP426

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 1

Chain	Residue
F	ASP328
F	HIS361
F	HIS365
F	HIS371

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 2

Chain	Residue
F	GLU221
F	ASP304
F	ASP311
F	CYS423
F	ASP426

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA F 3

Chain	Residue
F	GLU221
F	ASP304
F	ASP426

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 1

Chain	Residue
G	ASP328
G	HIS361
G	HIS365
G	HIS371

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA G 2

Chain	Residue
G	GLU221
G	ASP304
G	ASP311
G	CYS423
G	ASP426

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA G 3

Chain	Residue
G	GLU221
G	ASP304
G	ASP426
G	HOH521

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 1

Chain	Residue
H	ASP328
H	HIS361
H	HIS365
H	HIS371

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA H 2

Chain	Residue
H	ASP304
H	ASP311
H	CYS423
H	ASP426
H	HOH524
H	GLU221

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA H 3

Chain	Residue
H	GLU221
H	ASP304
H	ASP426

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	840
Details	Domain: {"description":"Peptidase M12B","evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18042673","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18042673","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)