3APV
Crystal structure of the A variant of human alpha1-acid glycoprotein and amitriptyline complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002682 | biological_process | regulation of immune system process |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006953 | biological_process | acute-phase response |
| A | 0031093 | cellular_component | platelet alpha granule lumen |
| A | 0032731 | biological_process | positive regulation of interleukin-1 beta production |
| A | 0032732 | biological_process | positive regulation of interleukin-1 production |
| A | 0032760 | biological_process | positive regulation of tumor necrosis factor production |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0035580 | cellular_component | specific granule lumen |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0072562 | cellular_component | blood microparticle |
| B | 0002682 | biological_process | regulation of immune system process |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006953 | biological_process | acute-phase response |
| B | 0031093 | cellular_component | platelet alpha granule lumen |
| B | 0032731 | biological_process | positive regulation of interleukin-1 beta production |
| B | 0032732 | biological_process | positive regulation of interleukin-1 production |
| B | 0032760 | biological_process | positive regulation of tumor necrosis factor production |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0035580 | cellular_component | specific granule lumen |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0072562 | cellular_component | blood microparticle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE TP0 A 190 |
| Chain | Residue |
| A | VAL41 |
| A | TYR127 |
| A | ACY191 |
| A | HOH257 |
| A | PHE49 |
| A | PHE51 |
| A | LEU62 |
| A | VAL88 |
| A | ARG90 |
| A | HIS97 |
| A | ALA99 |
| A | PHE112 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACY A 191 |
| Chain | Residue |
| A | TYR27 |
| A | TYR127 |
| A | TP0190 |
| A | HOH257 |
| A | HOH258 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE TP0 B 190 |
| Chain | Residue |
| B | TYR37 |
| B | VAL41 |
| B | PHE49 |
| B | LEU62 |
| B | VAL88 |
| B | HIS97 |
| B | ALA99 |
| B | SER125 |
| B | TYR127 |
| B | HOH202 |
| B | HOH208 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15253437","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1567356","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1567356","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1567356","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15253437","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1567356","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000171","evidences":[{"source":"PubMed","id":"1567356","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
