3ALA

Crystal structure of vascular adhesion protein-1 in space group C2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005507	molecular_function	copper ion binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005769	cellular_component	early endosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0005902	cellular_component	microvillus
A	0006954	biological_process	inflammatory response
A	0007155	biological_process	cell adhesion
A	0008131	molecular_function	primary methylamine oxidase activity
A	0009308	biological_process	amine metabolic process
A	0009986	cellular_component	cell surface
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016641	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0046982	molecular_function	protein heterodimerization activity
A	0048038	molecular_function	quinone binding
A	0052595	molecular_function	aliphatic amine oxidase activity
B	0005507	molecular_function	copper ion binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005769	cellular_component	early endosome
B	0005783	cellular_component	endoplasmic reticulum
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0005902	cellular_component	microvillus
B	0006954	biological_process	inflammatory response
B	0007155	biological_process	cell adhesion
B	0008131	molecular_function	primary methylamine oxidase activity
B	0009308	biological_process	amine metabolic process
B	0009986	cellular_component	cell surface
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016641	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0046982	molecular_function	protein heterodimerization activity
B	0048038	molecular_function	quinone binding
B	0052595	molecular_function	aliphatic amine oxidase activity
C	0005507	molecular_function	copper ion binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005769	cellular_component	early endosome
C	0005783	cellular_component	endoplasmic reticulum
C	0005794	cellular_component	Golgi apparatus
C	0005886	cellular_component	plasma membrane
C	0005902	cellular_component	microvillus
C	0006954	biological_process	inflammatory response
C	0007155	biological_process	cell adhesion
C	0008131	molecular_function	primary methylamine oxidase activity
C	0009308	biological_process	amine metabolic process
C	0009986	cellular_component	cell surface
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016641	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0046982	molecular_function	protein heterodimerization activity
C	0048038	molecular_function	quinone binding
C	0052595	molecular_function	aliphatic amine oxidase activity
D	0005507	molecular_function	copper ion binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005769	cellular_component	early endosome
D	0005783	cellular_component	endoplasmic reticulum
D	0005794	cellular_component	Golgi apparatus
D	0005886	cellular_component	plasma membrane
D	0005902	cellular_component	microvillus
D	0006954	biological_process	inflammatory response
D	0007155	biological_process	cell adhesion
D	0008131	molecular_function	primary methylamine oxidase activity
D	0009308	biological_process	amine metabolic process
D	0009986	cellular_component	cell surface
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016641	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0046982	molecular_function	protein heterodimerization activity
D	0048038	molecular_function	quinone binding
D	0052595	molecular_function	aliphatic amine oxidase activity
E	0005507	molecular_function	copper ion binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005769	cellular_component	early endosome
E	0005783	cellular_component	endoplasmic reticulum
E	0005794	cellular_component	Golgi apparatus
E	0005886	cellular_component	plasma membrane
E	0005902	cellular_component	microvillus
E	0006954	biological_process	inflammatory response
E	0007155	biological_process	cell adhesion
E	0008131	molecular_function	primary methylamine oxidase activity
E	0009308	biological_process	amine metabolic process
E	0009986	cellular_component	cell surface
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0016641	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0046982	molecular_function	protein heterodimerization activity
E	0048038	molecular_function	quinone binding
E	0052595	molecular_function	aliphatic amine oxidase activity
F	0005507	molecular_function	copper ion binding
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005769	cellular_component	early endosome
F	0005783	cellular_component	endoplasmic reticulum
F	0005794	cellular_component	Golgi apparatus
F	0005886	cellular_component	plasma membrane
F	0005902	cellular_component	microvillus
F	0006954	biological_process	inflammatory response
F	0007155	biological_process	cell adhesion
F	0008131	molecular_function	primary methylamine oxidase activity
F	0009308	biological_process	amine metabolic process
F	0009986	cellular_component	cell surface
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0016641	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
F	0046982	molecular_function	protein heterodimerization activity
F	0048038	molecular_function	quinone binding
F	0052595	molecular_function	aliphatic amine oxidase activity
G	0005507	molecular_function	copper ion binding
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005769	cellular_component	early endosome
G	0005783	cellular_component	endoplasmic reticulum
G	0005794	cellular_component	Golgi apparatus
G	0005886	cellular_component	plasma membrane
G	0005902	cellular_component	microvillus
G	0006954	biological_process	inflammatory response
G	0007155	biological_process	cell adhesion
G	0008131	molecular_function	primary methylamine oxidase activity
G	0009308	biological_process	amine metabolic process
G	0009986	cellular_component	cell surface
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016641	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
G	0046982	molecular_function	protein heterodimerization activity
G	0048038	molecular_function	quinone binding
G	0052595	molecular_function	aliphatic amine oxidase activity

Functional Information from PROSITE/UniProt

site_id	PS01164
Number of Residues	14
Details	COPPER_AMINE_OXID_1 Copper amine oxidase topaquinone signature. LVVrsmsTllNYDY

Chain	Residue	Details
A	LEU460-TYR473

---

site_id	PS01165
Number of Residues	14
Details	COPPER_AMINE_OXID_2 Copper amine oxidase copper-binding site signature. TaGflHIphaEDiP

Chain	Residue	Details
A	THR679-PRO692

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P19801

Chain	Residue	Details
A	ASP386
B	ASP386
C	ASP386
D	ASP386
E	ASP386
F	ASP386
G	ASP386

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	ACT_SITE: Schiff-base intermediate with substrate; via topaquinone => ECO:0000269|PubMed:16046623, ECO:0007744|PDB:1PU4, ECO:0007744|PDB:1US1

Chain	Residue	Details
A	TPQ471
B	TPQ471
C	TPQ471
D	TPQ471
E	TPQ471
F	TPQ471
G	TPQ471

---

site_id	SWS_FT_FI3
Number of Residues	91
Details	BINDING: BINDING => ECO:0000269|PubMed:16046623, ECO:0000269|PubMed:24304424, ECO:0007744|PDB:1PU4, ECO:0007744|PDB:1US1, ECO:0007744|PDB:4BTW, ECO:0007744|PDB:4BTX, ECO:0007744|PDB:4BTY

Chain	Residue	Details
A	HIS520
A	GLU667
A	ASP673
A	LEU674
A	HIS684
B	HIS520
B	HIS522
B	ASP529
B	LEU530
B	ASP531
B	GLU572
A	HIS522
B	GLU641
B	PHE663
B	ASN665
B	GLU667
B	ASP673
B	LEU674
B	HIS684
C	HIS520
C	HIS522
C	ASP529
A	ASP529
C	LEU530
C	ASP531
C	GLU572
C	GLU641
C	PHE663
C	ASN665
C	GLU667
C	ASP673
C	LEU674
C	HIS684
A	LEU530
D	HIS520
D	HIS522
D	ASP529
D	LEU530
D	ASP531
D	GLU572
D	GLU641
D	PHE663
D	ASN665
D	GLU667
A	ASP531
D	ASP673
D	LEU674
D	HIS684
E	HIS520
E	HIS522
E	ASP529
E	LEU530
E	ASP531
E	GLU572
E	GLU641
A	GLU572
E	PHE663
E	ASN665
E	GLU667
E	ASP673
E	LEU674
E	HIS684
F	HIS520
F	HIS522
F	ASP529
F	LEU530
A	GLU641
F	ASP531
F	GLU572
F	GLU641
F	PHE663
F	ASN665
F	GLU667
F	ASP673
F	LEU674
F	HIS684
G	HIS520
A	PHE663
G	HIS522
G	ASP529
G	LEU530
G	ASP531
G	GLU572
G	GLU641
G	PHE663
G	ASN665
G	GLU667
G	ASP673
A	ASN665
G	LEU674
G	HIS684

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	MOD_RES: 2',4',5'-topaquinone => ECO:0000269|PubMed:16046623, ECO:0007744|PDB:1PU4

Chain	Residue	Details
A	TPQ471
B	TPQ471
C	TPQ471
D	TPQ471
E	TPQ471
F	TPQ471
G	TPQ471

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	CARBOHYD: O-linked (GalNAc...) serine => ECO:0000305|PubMed:16046623

Chain	Residue	Details
A	SER43
B	SER43
C	SER43
D	SER43
E	SER43
F	SER43
G	SER43

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16046623, ECO:0000269|PubMed:19159218, ECO:0007744|PDB:1PU4, ECO:0007744|PDB:1US1

Chain	Residue	Details
A	ASN137
B	ASN137
C	ASN137
D	ASN137
E	ASN137
F	ASN137
G	ASN137

---

site_id	SWS_FT_FI7
Number of Residues	7
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000305|PubMed:16046623

Chain	Residue	Details
A	THR212
B	THR212
C	THR212
D	THR212
E	THR212
F	THR212
G	THR212

---

site_id	SWS_FT_FI8
Number of Residues	7
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16046623, ECO:0000269|PubMed:24304424, ECO:0007744|PDB:1PU4, ECO:0007744|PDB:1US1, ECO:0007744|PDB:4BTX, ECO:0007744|PDB:4BTY

Chain	Residue	Details
A	ASN232
B	ASN232
C	ASN232
D	ASN232
E	ASN232
F	ASN232
G	ASN232

---

site_id	SWS_FT_FI9
Number of Residues	7
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16046623, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:24304424, ECO:0007744|PDB:4BTY

Chain	Residue	Details
A	ASN294
B	ASN294
C	ASN294
D	ASN294
E	ASN294
F	ASN294
G	ASN294

---

site_id	SWS_FT_FI10
Number of Residues	7
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16046623, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:24304424, ECO:0007744|PDB:4BTW, ECO:0007744|PDB:4BTX, ECO:0007744|PDB:4BTY

Chain	Residue	Details
A	ASN592
B	ASN592
C	ASN592
D	ASN592
E	ASN592
F	ASN592
G	ASN592

---

site_id	SWS_FT_FI11
Number of Residues	7
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16046623, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:24304424, ECO:0007744|PDB:4BTW, ECO:0007744|PDB:4BTX

Chain	Residue	Details
A	ASN618
B	ASN618
C	ASN618
D	ASN618
E	ASN618
F	ASN618
G	ASN618

---

site_id	SWS_FT_FI12
Number of Residues	7
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16046623, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:24304424, ECO:0007744|PDB:4BTW, ECO:0007744|PDB:4BTX, ECO:0007744|PDB:4BTY

Chain	Residue	Details
A	ASN666
B	ASN666
C	ASN666
D	ASN666
E	ASN666
F	ASN666
G	ASN666

---

site_id	SWS_FT_FI13
Number of Residues	7
Details	CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000305|PubMed:16046623

Chain	Residue	Details
A	THR679
B	THR679
C	THR679
D	THR679
E	THR679
F	THR679
G	THR679

---