4BTX

Crystal structure of human vascular adhesion protein-1 in complex with pyridazinone inhibitors

Summary for 4BTX

Entry DOI	10.2210/pdb4btx/pdb
Related	4BTW 4BTY
Descriptor	MEMBRANE PRIMARY AMINE OXIDASE, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	oxidoreductase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Membrane; Single-pass type II membrane protein: Q16853
Total number of polymer chains	2
Total formula weight	167575.46
Authors	Bligt-Linden, E.,Pihlavisto, M.,Szatmari, I.,Otwinowski, Z.,Smith, D.J.,Lazar, L.,Fulop, F.,Salminen, T.A. (deposition date: 2013-06-19, release date: 2013-12-18, Last modification date: 2023-12-20)
Primary citation	Bligt-Linden, E.,Pihlavisto, M.,Szatmari, I.,Otwinowski, Z.,Smith, D.J.,Lazar, L.,Fulop, F.,Salminen, T.A. Novel Pyridazinone Inhibitors for Vascular Adhesion Protein- 1 (Vap-1): Old Target - New Inhibition Mode. J.Med.Chem., 56:9837-, 2013 Cited by PubMed: 24304424 DOI: 10.1021/JM401372D PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.78 Å)

Structure validation