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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

3A6P

Crystal structure of Exportin-5:RanGTP:pre-miRNA complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000049molecular_functiontRNA binding
A0003723molecular_functionRNA binding
A0003729molecular_functionmRNA binding
A0005049molecular_functionnuclear export signal receptor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006405biological_processRNA export from nucleus
A0006611biological_processprotein export from nucleus
A0006886biological_processintracellular protein transport
A0010586biological_processmiRNA metabolic process
A0015031biological_processprotein transport
A0016442cellular_componentRISC complex
A0031047biological_processregulatory ncRNA-mediated gene silencing
A0031267molecular_functionsmall GTPase binding
A0035281biological_processpre-miRNA export from nucleus
A0042565cellular_componentRNA nuclear export complex
A0070883molecular_functionpre-miRNA binding
A1905172molecular_functionRISC complex binding
C0000054biological_processribosomal subunit export from nucleus
C0000070biological_processmitotic sister chromatid segregation
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0003924molecular_functionGTPase activity
C0005049molecular_functionnuclear export signal receptor activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005635cellular_componentnuclear envelope
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006606biological_processprotein import into nucleus
C0006611biological_processprotein export from nucleus
C0006913biological_processnucleocytoplasmic transport
C0015031biological_processprotein transport
C0016442cellular_componentRISC complex
C0016787molecular_functionhydrolase activity
C0032991cellular_componentprotein-containing complex
C0035281biological_processpre-miRNA export from nucleus
C0042470cellular_componentmelanosome
C0046039biological_processGTP metabolic process
C0046827biological_processpositive regulation of protein export from nucleus
C0046872molecular_functionmetal ion binding
C0051301biological_processcell division
C0061015biological_processsnRNA import into nucleus
C0070883molecular_functionpre-miRNA binding
C1905172molecular_functionRISC complex binding
F0000049molecular_functiontRNA binding
F0003723molecular_functionRNA binding
F0003729molecular_functionmRNA binding
F0005049molecular_functionnuclear export signal receptor activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006405biological_processRNA export from nucleus
F0006611biological_processprotein export from nucleus
F0006886biological_processintracellular protein transport
F0010586biological_processmiRNA metabolic process
F0015031biological_processprotein transport
F0016442cellular_componentRISC complex
F0031047biological_processregulatory ncRNA-mediated gene silencing
F0031267molecular_functionsmall GTPase binding
F0035281biological_processpre-miRNA export from nucleus
F0042565cellular_componentRNA nuclear export complex
F0070883molecular_functionpre-miRNA binding
F1905172molecular_functionRISC complex binding
H0000054biological_processribosomal subunit export from nucleus
H0000070biological_processmitotic sister chromatid segregation
H0000166molecular_functionnucleotide binding
H0000287molecular_functionmagnesium ion binding
H0003924molecular_functionGTPase activity
H0005049molecular_functionnuclear export signal receptor activity
H0005515molecular_functionprotein binding
H0005525molecular_functionGTP binding
H0005634cellular_componentnucleus
H0005635cellular_componentnuclear envelope
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006606biological_processprotein import into nucleus
H0006611biological_processprotein export from nucleus
H0006913biological_processnucleocytoplasmic transport
H0015031biological_processprotein transport
H0016442cellular_componentRISC complex
H0016787molecular_functionhydrolase activity
H0032991cellular_componentprotein-containing complex
H0035281biological_processpre-miRNA export from nucleus
H0042470cellular_componentmelanosome
H0046039biological_processGTP metabolic process
H0046827biological_processpositive regulation of protein export from nucleus
H0046872molecular_functionmetal ion binding
H0051301biological_processcell division
H0061015biological_processsnRNA import into nucleus
H0070883molecular_functionpre-miRNA binding
H1905172molecular_functionRISC complex binding
Functional Information from PDB Data
site_idAC1
Number of Residues20
DetailsBINDING SITE FOR RESIDUE GTP C 1177
ChainResidue
CASP18
CTYR39
CTHR42
CGLY68
CASN122
CLYS123
CASP125
CILE126
CSER150
CALA151
CLYS152
CGLY19
CMG1178
CGLY20
CGLY22
CLYS23
CTHR24
CTHR25
CGLU36
CLYS37
site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG C 1178
ChainResidue
CTHR24
CTHR42
CASP65
CGTP1177
site_idAC3
Number of Residues25
DetailsBINDING SITE FOR RESIDUE GTP H 1177
ChainResidue
HASP18
HGLY19
HGLY20
HTHR21
HGLY22
HLYS23
HTHR24
HTHR25
HPHE35
HGLU36
HLYS37
HLYS38
HTYR39
HTHR42
HALA67
HGLY68
HGLN69
HASN122
HLYS123
HASP125
HILE126
HSER150
HALA151
HLYS152
HMG1178
site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG H 1178
ChainResidue
HTHR24
HTHR42
HGTP1177
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues212
DetailsRegion: {"description":"Necessary for interaction with Ran"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues214
DetailsRegion: {"description":"Necessary for interaction with ILF3"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsRegion: {"description":"Pre-miRNA binding","evidences":[{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsSite: {"description":"Pre-miRNA binding","evidences":[{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues328
DetailsDomain: {"description":"Small GTPase Ran-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues16
DetailsRegion: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues32
DetailsRegion: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15864302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9533885","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9878368","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3A6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W3Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BXQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15864302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3A6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W3Z","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15864302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W3Z","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsSite: {"description":"Essential for GTP hydrolysis","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62827","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
CGLN69
site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
HGLN69

238582

PDB entries from 2025-07-09

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