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2ZVM

Crystal structure of PCNA in complex with DNA polymerase iota fragment

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
A0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0001673cellular_componentmale germ cell nucleus
A0003677molecular_functionDNA binding
A0003682molecular_functionchromatin binding
A0003684molecular_functiondamaged DNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005652cellular_componentnuclear lamina
A0005654cellular_componentnucleoplasm
A0005657cellular_componentreplication fork
A0005813cellular_componentcentrosome
A0006260biological_processDNA replication
A0006272biological_processleading strand elongation
A0006275biological_processregulation of DNA replication
A0006281biological_processDNA repair
A0006287biological_processbase-excision repair, gap-filling
A0006298biological_processmismatch repair
A0006979biological_processresponse to oxidative stress
A0007507biological_processheart development
A0016604cellular_componentnuclear body
A0019899molecular_functionenzyme binding
A0019985biological_processtranslesion synthesis
A0030331molecular_functionnuclear estrogen receptor binding
A0030337molecular_functionDNA polymerase processivity factor activity
A0030855biological_processepithelial cell differentiation
A0030894cellular_componentreplisome
A0030971molecular_functionreceptor tyrosine kinase binding
A0031297biological_processreplication fork processing
A0032077biological_processpositive regulation of deoxyribonuclease activity
A0032139molecular_functiondinucleotide insertion or deletion binding
A0032355biological_processresponse to estradiol
A0032405molecular_functionMutLalpha complex binding
A0033993biological_processresponse to lipid
A0034644biological_processcellular response to UV
A0035035molecular_functionhistone acetyltransferase binding
A0042802molecular_functionidentical protein binding
A0043596cellular_componentnuclear replication fork
A0043626cellular_componentPCNA complex
A0044849biological_processestrous cycle
A0044877molecular_functionprotein-containing complex binding
A0045739biological_processpositive regulation of DNA repair
A0045740biological_processpositive regulation of DNA replication
A0046686biological_processresponse to cadmium ion
A0070062cellular_componentextracellular exosome
A0070182molecular_functionDNA polymerase binding
A0070301biological_processcellular response to hydrogen peroxide
A0070557cellular_componentPCNA-p21 complex
A0071466biological_processcellular response to xenobiotic stimulus
A0071548biological_processresponse to dexamethasone
A0097421biological_processliver regeneration
A1900264biological_processpositive regulation of DNA-directed DNA polymerase activity
A1902065biological_processresponse to L-glutamate
A1902990biological_processmitotic telomere maintenance via semi-conservative replication
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
B0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
B0000781cellular_componentchromosome, telomeric region
B0000785cellular_componentchromatin
B0001673cellular_componentmale germ cell nucleus
B0003677molecular_functionDNA binding
B0003682molecular_functionchromatin binding
B0003684molecular_functiondamaged DNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005652cellular_componentnuclear lamina
B0005654cellular_componentnucleoplasm
B0005657cellular_componentreplication fork
B0005813cellular_componentcentrosome
B0006260biological_processDNA replication
B0006272biological_processleading strand elongation
B0006275biological_processregulation of DNA replication
B0006281biological_processDNA repair
B0006287biological_processbase-excision repair, gap-filling
B0006298biological_processmismatch repair
B0006979biological_processresponse to oxidative stress
B0007507biological_processheart development
B0016604cellular_componentnuclear body
B0019899molecular_functionenzyme binding
B0019985biological_processtranslesion synthesis
B0030331molecular_functionnuclear estrogen receptor binding
B0030337molecular_functionDNA polymerase processivity factor activity
B0030855biological_processepithelial cell differentiation
B0030894cellular_componentreplisome
B0030971molecular_functionreceptor tyrosine kinase binding
B0031297biological_processreplication fork processing
B0032077biological_processpositive regulation of deoxyribonuclease activity
B0032139molecular_functiondinucleotide insertion or deletion binding
B0032355biological_processresponse to estradiol
B0032405molecular_functionMutLalpha complex binding
B0033993biological_processresponse to lipid
B0034644biological_processcellular response to UV
B0035035molecular_functionhistone acetyltransferase binding
B0042802molecular_functionidentical protein binding
B0043596cellular_componentnuclear replication fork
B0043626cellular_componentPCNA complex
B0044849biological_processestrous cycle
B0044877molecular_functionprotein-containing complex binding
B0045739biological_processpositive regulation of DNA repair
B0045740biological_processpositive regulation of DNA replication
B0046686biological_processresponse to cadmium ion
B0070062cellular_componentextracellular exosome
B0070182molecular_functionDNA polymerase binding
B0070301biological_processcellular response to hydrogen peroxide
B0070557cellular_componentPCNA-p21 complex
B0071466biological_processcellular response to xenobiotic stimulus
B0071548biological_processresponse to dexamethasone
B0097421biological_processliver regeneration
B1900264biological_processpositive regulation of DNA-directed DNA polymerase activity
B1902065biological_processresponse to L-glutamate
B1902990biological_processmitotic telomere maintenance via semi-conservative replication
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
C0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
C0000781cellular_componentchromosome, telomeric region
C0000785cellular_componentchromatin
C0001673cellular_componentmale germ cell nucleus
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0003684molecular_functiondamaged DNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005652cellular_componentnuclear lamina
C0005654cellular_componentnucleoplasm
C0005657cellular_componentreplication fork
C0005813cellular_componentcentrosome
C0006260biological_processDNA replication
C0006272biological_processleading strand elongation
C0006275biological_processregulation of DNA replication
C0006281biological_processDNA repair
C0006287biological_processbase-excision repair, gap-filling
C0006298biological_processmismatch repair
C0006979biological_processresponse to oxidative stress
C0007507biological_processheart development
C0016604cellular_componentnuclear body
C0019899molecular_functionenzyme binding
C0019985biological_processtranslesion synthesis
C0030331molecular_functionnuclear estrogen receptor binding
C0030337molecular_functionDNA polymerase processivity factor activity
C0030855biological_processepithelial cell differentiation
C0030894cellular_componentreplisome
C0030971molecular_functionreceptor tyrosine kinase binding
C0031297biological_processreplication fork processing
C0032077biological_processpositive regulation of deoxyribonuclease activity
C0032139molecular_functiondinucleotide insertion or deletion binding
C0032355biological_processresponse to estradiol
C0032405molecular_functionMutLalpha complex binding
C0033993biological_processresponse to lipid
C0034644biological_processcellular response to UV
C0035035molecular_functionhistone acetyltransferase binding
C0042802molecular_functionidentical protein binding
C0043596cellular_componentnuclear replication fork
C0043626cellular_componentPCNA complex
C0044849biological_processestrous cycle
C0044877molecular_functionprotein-containing complex binding
C0045739biological_processpositive regulation of DNA repair
C0045740biological_processpositive regulation of DNA replication
C0046686biological_processresponse to cadmium ion
C0070062cellular_componentextracellular exosome
C0070182molecular_functionDNA polymerase binding
C0070301biological_processcellular response to hydrogen peroxide
C0070557cellular_componentPCNA-p21 complex
C0071466biological_processcellular response to xenobiotic stimulus
C0071548biological_processresponse to dexamethasone
C0097421biological_processliver regeneration
C1900264biological_processpositive regulation of DNA-directed DNA polymerase activity
C1902065biological_processresponse to L-glutamate
C1902990biological_processmitotic telomere maintenance via semi-conservative replication
Functional Information from PROSITE/UniProt
site_idPS00293
Number of Residues19
DetailsPCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlaMgvnLtSMsKIL
ChainResidueDetails
AARG61-LEU79

site_idPS01251
Number of Residues24
DetailsPCNA_1 Proliferating cell nuclear antigen signature 1. GVnLqSMDsSHVsLVqLtLrsegF
ChainResidueDetails
AGLY34-PHE57

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues57
DetailsDNA_BIND: DNA_BIND => ECO:0000255
ChainResidueDetails
AARG61-LYS80
BARG61-LYS80
CARG61-LYS80

site_idSWS_FT_FI2
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:19419956
ChainResidueDetails
ALYS14
BLYS14
CLYS14

site_idSWS_FT_FI3
Number of Residues9
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS77
ALYS80
ALYS248
BLYS77
BLYS80
BLYS248
CLYS77
CLYS80
CLYS248

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: Phosphotyrosine; by EGFR => ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:38459011
ChainResidueDetails
ATYR211
BTYR211
CTYR211

site_idSWS_FT_FI5
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289
ChainResidueDetails
ALYS164
BLYS164
CLYS164

site_idSWS_FT_FI6
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS254
BLYS254
CLYS254

227344

PDB entries from 2024-11-13

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