2ZU6

crystal structure of the eIF4A-PDCD4 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000339	molecular_function	RNA cap binding
A	0002183	biological_process	cytoplasmic translational initiation
A	0003676	molecular_function	nucleic acid binding
A	0003689	molecular_function	DNA clamp loader activity
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0003725	molecular_function	double-stranded RNA binding
A	0003729	molecular_function	mRNA binding
A	0003743	molecular_function	translation initiation factor activity
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006338	biological_process	chromatin remodeling
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0008135	molecular_function	translation factor activity, RNA binding
A	0010494	cellular_component	cytoplasmic stress granule
A	0016020	cellular_component	membrane
A	0016281	cellular_component	eukaryotic translation initiation factor 4F complex
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0061775	molecular_function	cohesin loader activity
A	0070062	cellular_component	extracellular exosome
A	0097165	cellular_component	nuclear stress granule
A	0140584	molecular_function	chromatin extrusion motor activity
A	0140588	biological_process	chromatin looping
A	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
A	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
B	0045892	biological_process	negative regulation of DNA-templated transcription
C	0000339	molecular_function	RNA cap binding
C	0002183	biological_process	cytoplasmic translational initiation
C	0003676	molecular_function	nucleic acid binding
C	0003689	molecular_function	DNA clamp loader activity
C	0003723	molecular_function	RNA binding
C	0003724	molecular_function	RNA helicase activity
C	0003725	molecular_function	double-stranded RNA binding
C	0003729	molecular_function	mRNA binding
C	0003743	molecular_function	translation initiation factor activity
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006338	biological_process	chromatin remodeling
C	0006412	biological_process	translation
C	0006413	biological_process	translational initiation
C	0008135	molecular_function	translation factor activity, RNA binding
C	0010494	cellular_component	cytoplasmic stress granule
C	0016020	cellular_component	membrane
C	0016281	cellular_component	eukaryotic translation initiation factor 4F complex
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0061775	molecular_function	cohesin loader activity
C	0070062	cellular_component	extracellular exosome
C	0097165	cellular_component	nuclear stress granule
C	0140584	molecular_function	chromatin extrusion motor activity
C	0140588	biological_process	chromatin looping
C	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
C	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
D	0000339	molecular_function	RNA cap binding
D	0002183	biological_process	cytoplasmic translational initiation
D	0003676	molecular_function	nucleic acid binding
D	0003689	molecular_function	DNA clamp loader activity
D	0003723	molecular_function	RNA binding
D	0003724	molecular_function	RNA helicase activity
D	0003725	molecular_function	double-stranded RNA binding
D	0003729	molecular_function	mRNA binding
D	0003743	molecular_function	translation initiation factor activity
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006338	biological_process	chromatin remodeling
D	0006412	biological_process	translation
D	0006413	biological_process	translational initiation
D	0008135	molecular_function	translation factor activity, RNA binding
D	0010494	cellular_component	cytoplasmic stress granule
D	0016020	cellular_component	membrane
D	0016281	cellular_component	eukaryotic translation initiation factor 4F complex
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0061775	molecular_function	cohesin loader activity
D	0070062	cellular_component	extracellular exosome
D	0097165	cellular_component	nuclear stress granule
D	0140584	molecular_function	chromatin extrusion motor activity
D	0140588	biological_process	chromatin looping
D	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
D	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
E	0045892	biological_process	negative regulation of DNA-templated transcription
F	0000339	molecular_function	RNA cap binding
F	0002183	biological_process	cytoplasmic translational initiation
F	0003676	molecular_function	nucleic acid binding
F	0003689	molecular_function	DNA clamp loader activity
F	0003723	molecular_function	RNA binding
F	0003724	molecular_function	RNA helicase activity
F	0003725	molecular_function	double-stranded RNA binding
F	0003729	molecular_function	mRNA binding
F	0003743	molecular_function	translation initiation factor activity
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006338	biological_process	chromatin remodeling
F	0006412	biological_process	translation
F	0006413	biological_process	translational initiation
F	0008135	molecular_function	translation factor activity, RNA binding
F	0010494	cellular_component	cytoplasmic stress granule
F	0016020	cellular_component	membrane
F	0016281	cellular_component	eukaryotic translation initiation factor 4F complex
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0061775	molecular_function	cohesin loader activity
F	0070062	cellular_component	extracellular exosome
F	0097165	cellular_component	nuclear stress granule
F	0140584	molecular_function	chromatin extrusion motor activity
F	0140588	biological_process	chromatin looping
F	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
F	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 2

Chain	Residue
A	SER218
A	GLU222
A	LYS225

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 3

Chain	Residue
A	ASP185
A	SER213
A	ALA214
A	ALA76
A	GLN77
A	SER78
A	THR80
A	ASP182
A	GLU183

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ACY A 1

Chain	Residue
A	SER89

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO D 1

Chain	Residue
D	SER89
D	GLN93

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACY D 2

Chain	Residue
D	ARG141
D	TYR170

---

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADEmL

Chain	Residue	Details
A	VAL180-LEU188

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	SER313
B	SER317
E	SER313
E	SER317

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKB => ECO:0000269|PubMed:16357133, ECO:0007744|PubMed:15144186, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER457
E	SER457
C	LYS118
C	LYS174
D	LYS118
D	LYS174
F	LYS118
F	LYS174

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR158
C	THR158
D	THR158
F	THR158

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P60843

Chain	Residue	Details
A	LYS193
C	LYS193
D	LYS193
F	LYS193

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P60843

Chain	Residue	Details
A	LYS238
C	LYS238
D	LYS238
F	LYS238

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS146
C	LYS309
C	LYS369
C	LYS381
D	LYS146
D	LYS225
D	LYS309
D	LYS369
D	LYS381
F	LYS146
F	LYS225
F	LYS309
F	LYS369
F	LYS381
A	LYS225
A	LYS309
A	LYS369
A	LYS381
C	LYS146
C	LYS225

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS238
C	LYS238
D	LYS238
F	LYS238

---