2ZKU
Structure of hepatitis C virus NS5B polymerase in a new crystal form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| B | 0039694 | biological_process | viral RNA genome replication |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| C | 0039694 | biological_process | viral RNA genome replication |
| D | 0003723 | molecular_function | RNA binding |
| D | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| D | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACY A 3001 |
| Chain | Residue |
| A | ARG501 |
| A | TRP528 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACY A 3005 |
| Chain | Residue |
| A | ARG222 |
| A | CYS223 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 4001 |
| Chain | Residue |
| A | ALA105 |
| A | LYS106 |
| A | PRO94 |
| A | HIS95 |
| A | SER96 |
| A | LYS98 |
| A | GLY104 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 4002 |
| Chain | Residue |
| A | ASP129 |
| A | VAL131 |
| A | THR132 |
| D | LEU60 |
| D | LEU68 |
| D | ASN231 |
| D | VAL235 |
| D | HOH3008 |
| D | HOH3303 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 4004 |
| Chain | Residue |
| A | PHE203 |
| A | ASN206 |
| A | THR207 |
| A | SER210 |
| A | THR312 |
| A | HOH4007 |
| A | HOH4190 |
| B | ARG508 |
| B | HOH4034 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 4005 |
| Chain | Residue |
| A | SER96 |
| A | ALA97 |
| A | ARG168 |
| A | GLY557 |
| A | HOH4108 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 4006 |
| Chain | Residue |
| A | GLU202 |
| A | ASN206 |
| A | LYS209 |
| A | HOH4024 |
| A | HOH4041 |
| B | SER506 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACY B 3003 |
| Chain | Residue |
| B | ARG465 |
| B | LEU547 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACY B 3004 |
| Chain | Residue |
| B | TRP408 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY B 3007 |
| Chain | Residue |
| B | SER218 |
| B | GLU357 |
| B | LEU362 |
| B | ILE363 |
| B | THR364 |
| B | HOH4524 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 4003 |
| Chain | Residue |
| B | PHE203 |
| B | ASN206 |
| B | THR207 |
| B | HOH4036 |
| B | HOH4114 |
| D | ARG508 |
| D | HOH3035 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 4007 |
| Chain | Residue |
| B | ALA97 |
| B | ILE160 |
| B | PHE162 |
| B | ARG168 |
| B | HOH4125 |
| B | HOH4158 |
| B | HOH4355 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACY C 3002 |
| Chain | Residue |
| A | HIS502 |
| C | GLY198 |
| C | GLN199 |
| C | GLU202 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACY D 3006 |
| Chain | Residue |
| D | LEU474 |
| D | ARG501 |
| D | TRP528 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 |
| Chain | Residue | Details |
| A | ASP220 | |
| D | ASP220 | |
| D | ASP318 | |
| D | ASP319 | |
| A | ASP318 | |
| A | ASP319 | |
| B | ASP220 | |
| B | ASP318 | |
| B | ASP319 | |
| C | ASP220 | |
| C | ASP318 | |
| C | ASP319 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 |
| Chain | Residue | Details |
| A | SER29 | |
| A | SER42 | |
| B | SER29 | |
| B | SER42 | |
| C | SER29 | |
| C | SER42 | |
| D | SER29 | |
| D | SER42 |
