Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2ZJP

Thiopeptide antibiotic Nosiheptide bound to the large ribosomal subunit of Deinococcus radiodurans

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000049	molecular_function	tRNA binding
1	0003723	molecular_function	RNA binding
1	0003735	molecular_function	structural constituent of ribosome
1	0005737	cellular_component	cytoplasm
1	0005840	cellular_component	ribosome
1	0006412	biological_process	translation
1	0019843	molecular_function	rRNA binding
1	0022625	cellular_component	cytosolic large ribosomal subunit
1	0043229	cellular_component	intracellular organelle
1	1990904	cellular_component	ribonucleoprotein complex
2	0003723	molecular_function	RNA binding
2	0003735	molecular_function	structural constituent of ribosome
2	0005840	cellular_component	ribosome
2	0006412	biological_process	translation
2	0019843	molecular_function	rRNA binding
2	1990904	cellular_component	ribonucleoprotein complex
3	0003723	molecular_function	RNA binding
3	0003735	molecular_function	structural constituent of ribosome
3	0005840	cellular_component	ribosome
3	0006412	biological_process	translation
3	0019843	molecular_function	rRNA binding
3	0022625	cellular_component	cytosolic large ribosomal subunit
3	1990904	cellular_component	ribonucleoprotein complex
4	0003723	molecular_function	RNA binding
4	0003735	molecular_function	structural constituent of ribosome
4	0005737	cellular_component	cytoplasm
4	0005840	cellular_component	ribosome
4	0006412	biological_process	translation
4	0019843	molecular_function	rRNA binding
4	0043229	cellular_component	intracellular organelle
4	0046872	molecular_function	metal ion binding
4	1990904	cellular_component	ribonucleoprotein complex
A	0002181	biological_process	cytoplasmic translation
A	0003723	molecular_function	RNA binding
A	0003735	molecular_function	structural constituent of ribosome
A	0005840	cellular_component	ribosome
A	0006412	biological_process	translation
A	0015934	cellular_component	large ribosomal subunit
A	0016740	molecular_function	transferase activity
A	0019843	molecular_function	rRNA binding
A	0022625	cellular_component	cytosolic large ribosomal subunit
A	1990904	cellular_component	ribonucleoprotein complex
B	0003723	molecular_function	RNA binding
B	0003735	molecular_function	structural constituent of ribosome
B	0005840	cellular_component	ribosome
B	0006412	biological_process	translation
B	0019843	molecular_function	rRNA binding
B	0022625	cellular_component	cytosolic large ribosomal subunit
B	1990904	cellular_component	ribonucleoprotein complex
C	0003723	molecular_function	RNA binding
C	0003735	molecular_function	structural constituent of ribosome
C	0005840	cellular_component	ribosome
C	0006412	biological_process	translation
C	0019843	molecular_function	rRNA binding
C	1990904	cellular_component	ribonucleoprotein complex
D	0000049	molecular_function	tRNA binding
D	0003723	molecular_function	RNA binding
D	0003735	molecular_function	structural constituent of ribosome
D	0005840	cellular_component	ribosome
D	0006412	biological_process	translation
D	0019843	molecular_function	rRNA binding
D	0022625	cellular_component	cytosolic large ribosomal subunit
D	1990904	cellular_component	ribonucleoprotein complex
E	0002181	biological_process	cytoplasmic translation
E	0003723	molecular_function	RNA binding
E	0003735	molecular_function	structural constituent of ribosome
E	0005840	cellular_component	ribosome
E	0006412	biological_process	translation
E	0019843	molecular_function	rRNA binding
E	0022625	cellular_component	cytosolic large ribosomal subunit
E	1990904	cellular_component	ribonucleoprotein complex
F	0003723	molecular_function	RNA binding
F	0003735	molecular_function	structural constituent of ribosome
F	0005840	cellular_component	ribosome
F	0006412	biological_process	translation
F	0019843	molecular_function	rRNA binding
F	0022625	cellular_component	cytosolic large ribosomal subunit
F	0070180	molecular_function	large ribosomal subunit rRNA binding
F	1990904	cellular_component	ribonucleoprotein complex
G	0003723	molecular_function	RNA binding
G	0003729	molecular_function	mRNA binding
G	0003735	molecular_function	structural constituent of ribosome
G	0005737	cellular_component	cytoplasm
G	0005840	cellular_component	ribosome
G	0006412	biological_process	translation
G	0017148	biological_process	negative regulation of translation
G	0019843	molecular_function	rRNA binding
G	0022625	cellular_component	cytosolic large ribosomal subunit
G	0043229	cellular_component	intracellular organelle
G	1990904	cellular_component	ribonucleoprotein complex
H	0003723	molecular_function	RNA binding
H	0003735	molecular_function	structural constituent of ribosome
H	0005840	cellular_component	ribosome
H	0006412	biological_process	translation
H	0015934	cellular_component	large ribosomal subunit
H	0019843	molecular_function	rRNA binding
H	0022625	cellular_component	cytosolic large ribosomal subunit
H	0070180	molecular_function	large ribosomal subunit rRNA binding
H	1990904	cellular_component	ribonucleoprotein complex
I	0003723	molecular_function	RNA binding
I	0003735	molecular_function	structural constituent of ribosome
I	0005840	cellular_component	ribosome
I	0006412	biological_process	translation
I	0015934	cellular_component	large ribosomal subunit
I	0019843	molecular_function	rRNA binding
I	0022625	cellular_component	cytosolic large ribosomal subunit
I	1990904	cellular_component	ribonucleoprotein complex
J	0000049	molecular_function	tRNA binding
J	0003723	molecular_function	RNA binding
J	0003735	molecular_function	structural constituent of ribosome
J	0005840	cellular_component	ribosome
J	0006412	biological_process	translation
J	0019843	molecular_function	rRNA binding
J	0022625	cellular_component	cytosolic large ribosomal subunit
J	1990904	cellular_component	ribonucleoprotein complex
K	0003723	molecular_function	RNA binding
K	0003735	molecular_function	structural constituent of ribosome
K	0005840	cellular_component	ribosome
K	0006412	biological_process	translation
K	0019843	molecular_function	rRNA binding
K	0022625	cellular_component	cytosolic large ribosomal subunit
K	1990904	cellular_component	ribonucleoprotein complex
L	0003723	molecular_function	RNA binding
L	0003735	molecular_function	structural constituent of ribosome
L	0005737	cellular_component	cytoplasm
L	0005840	cellular_component	ribosome
L	0006412	biological_process	translation
L	0008097	molecular_function	5S rRNA binding
L	0019843	molecular_function	rRNA binding
L	0022625	cellular_component	cytosolic large ribosomal subunit
L	0043229	cellular_component	intracellular organelle
L	1990904	cellular_component	ribonucleoprotein complex
M	0003723	molecular_function	RNA binding
M	0003735	molecular_function	structural constituent of ribosome
M	0005840	cellular_component	ribosome
M	0006412	biological_process	translation
M	0019843	molecular_function	rRNA binding
M	0022625	cellular_component	cytosolic large ribosomal subunit
M	1990904	cellular_component	ribonucleoprotein complex
N	0003723	molecular_function	RNA binding
N	0003735	molecular_function	structural constituent of ribosome
N	0005840	cellular_component	ribosome
N	0006412	biological_process	translation
N	0019843	molecular_function	rRNA binding
N	0022625	cellular_component	cytosolic large ribosomal subunit
N	1990904	cellular_component	ribonucleoprotein complex
O	0003723	molecular_function	RNA binding
O	0003735	molecular_function	structural constituent of ribosome
O	0005737	cellular_component	cytoplasm
O	0005840	cellular_component	ribosome
O	0006412	biological_process	translation
O	0019843	molecular_function	rRNA binding
O	0043229	cellular_component	intracellular organelle
O	1990904	cellular_component	ribonucleoprotein complex
P	0003723	molecular_function	RNA binding
P	0003735	molecular_function	structural constituent of ribosome
P	0005840	cellular_component	ribosome
P	0006412	biological_process	translation
P	0015934	cellular_component	large ribosomal subunit
P	0019843	molecular_function	rRNA binding
P	0022625	cellular_component	cytosolic large ribosomal subunit
P	1990904	cellular_component	ribonucleoprotein complex
Q	0003723	molecular_function	RNA binding
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005840	cellular_component	ribosome
Q	0006412	biological_process	translation
Q	0019843	molecular_function	rRNA binding
Q	0022625	cellular_component	cytosolic large ribosomal subunit
Q	1990904	cellular_component	ribonucleoprotein complex
R	0003723	molecular_function	RNA binding
R	0003735	molecular_function	structural constituent of ribosome
R	0005840	cellular_component	ribosome
R	0006412	biological_process	translation
R	0019843	molecular_function	rRNA binding
R	0022625	cellular_component	cytosolic large ribosomal subunit
R	1990904	cellular_component	ribonucleoprotein complex
S	0000049	molecular_function	tRNA binding
S	0003723	molecular_function	RNA binding
S	0003735	molecular_function	structural constituent of ribosome
S	0005840	cellular_component	ribosome
S	0006412	biological_process	translation
S	0008097	molecular_function	5S rRNA binding
S	0019843	molecular_function	rRNA binding
S	0022625	cellular_component	cytosolic large ribosomal subunit
S	1990904	cellular_component	ribonucleoprotein complex
T	0000049	molecular_function	tRNA binding
T	0003723	molecular_function	RNA binding
T	0003735	molecular_function	structural constituent of ribosome
T	0005840	cellular_component	ribosome
T	0006412	biological_process	translation
T	0019843	molecular_function	rRNA binding
T	0022625	cellular_component	cytosolic large ribosomal subunit
T	1990904	cellular_component	ribonucleoprotein complex
U	0003735	molecular_function	structural constituent of ribosome
U	0005840	cellular_component	ribosome
U	0006412	biological_process	translation
U	1990904	cellular_component	ribonucleoprotein complex
V	0003723	molecular_function	RNA binding
V	0003735	molecular_function	structural constituent of ribosome
V	0005840	cellular_component	ribosome
V	0006412	biological_process	translation
V	0019843	molecular_function	rRNA binding
V	0022625	cellular_component	cytosolic large ribosomal subunit
V	1990904	cellular_component	ribonucleoprotein complex
W	0003723	molecular_function	RNA binding
W	0003735	molecular_function	structural constituent of ribosome
W	0005840	cellular_component	ribosome
W	0006412	biological_process	translation
W	0015934	cellular_component	large ribosomal subunit
W	0019843	molecular_function	rRNA binding
W	0022625	cellular_component	cytosolic large ribosomal subunit
W	1990904	cellular_component	ribonucleoprotein complex
Y	0003723	molecular_function	RNA binding
Y	0003735	molecular_function	structural constituent of ribosome
Y	0005840	cellular_component	ribosome
Y	0006412	biological_process	translation
Y	0015934	cellular_component	large ribosomal subunit
Y	0019843	molecular_function	rRNA binding
Y	0046872	molecular_function	metal ion binding
Y	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	1
Number of Residues
Details

Chain

Residue

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN 4 38

Chain	Residue
4	MET10
4	CYS11
4	CYS14
4	CYS27
4	HIS32

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG M 167

Chain	Residue
M	ASN58

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG X 2881

Chain	Residue
X	U2057
X	U2058

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG X 2882

Chain	Residue
X	G2415

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG X 2883

Chain	Residue
X	G1369
X	U1370

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG X 2884

Chain	Residue
X	G746
X	A747
X	A774

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG X 2885

Chain	Residue
X	C745
X	G772

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG X 2886

Chain	Residue
X	G1767

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG X 2887

Chain	Residue
X	C1765

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG X 2888

Chain	Residue
X	G2557

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG X 2889

Chain	Residue
X	G2743

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG X 2890

Chain	Residue
X	G2036
X	G2555
X	A2556

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG X 2894

Chain	Residue
X	A1980

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG X 2895

Chain	Residue
X	G2665
X	U2666
X	U2700

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG X 2896

Chain	Residue
X	G2699

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG X 2897

Chain	Residue
X	A815

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG X 2900

Chain	Residue
X	G1760
X	G1761
X	C1941

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG X 2903

Chain	Residue
X	G1266

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG X 2904

Chain	Residue
C	GLY79
X	A461
X	G462
X	G464

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG X 2905

Chain	Residue
X	C463
X	C465
X	U467

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG X 2907

Chain	Residue
X	C2431
X	U2564

site_id	CC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG X 2908

Chain	Residue
X	C2480

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN Y 61

Chain	Residue
Y	CYS33
Y	CYS36
Y	CYS46
Y	CYS49

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG Z 124

Chain	Residue
Z	G99
Z	G100

site_id	CC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG Z 127

Chain	Residue
Z	G105

site_id	CC8
Number of Residues	9
Details	BINDING SITE FOR LINKED RESIDUES 5 1 to 14

Chain	Residue
F	ALA20
F	PRO21
F	PRO25
F	ALA26
F	GLN29
X	A1078
X	G1079
X	A1106
X	A1107

Functional Information from PROSITE/UniProt

site_id	PS01015
Number of Residues	16
Details	RIBOSOMAL_L19 Ribosomal protein L19 signature. IvErGKVR.RAKLYYLR

Chain	Residue	Details
M	ILE93-ARG108

site_id	PS00049
Number of Residues	27
Details	RIBOSOMAL_L14 Ribosomal protein L14 signature. AVVVrtshaikra.DGstirFdrNaaVI

Chain	Residue	Details
H	ALA72-ILE98

site_id	PS01108
Number of Residues	18
Details	RIBOSOMAL_L24 Ribosomal protein L24 signature. GDtViVLsGkhKGqt.GkV

Chain	Residue	Details
R	GLY19-VAL36

site_id	PS00359
Number of Residues	16
Details	RIBOSOMAL_L11 Ribosomal protein L11 signature. NtVaGTarSMGvTVeG

Chain	Residue	Details
F	ASN125-GLY140

site_id	PS00784
Number of Residues	20
Details	RIBOSOMAL_L34 Ribosomal protein L34 signature. KRTYQpnnrkRakth.GFraR

Chain	Residue	Details
2	LYS2-ARG21

site_id	PS00828
Number of Residues	26
Details	RIBOSOMAL_L36 Ribosomal protein L36 signature. CdnCkvVrRhgrVlViCsnv.KHkQrQ

Chain	Residue	Details
4	CYS11-GLN36

site_id	PS00464
Number of Residues	25
Details	RIBOSOMAL_L22 Ribosomal protein L22 signature. KrlIpRArGSaniikkrtSHITIiV

Chain	Residue	Details
P	LYS104-VAL128

site_id	PS01167
Number of Residues	23
Details	RIBOSOMAL_L17 Ribosomal protein L17 signature. IqTTltKaKelrpfvEqLITtAK

Chain	Residue	Details
K	ILE34-LYS56

site_id	PS00582
Number of Residues	20
Details	RIBOSOMAL_L33 Ribosomal protein L33 signature. YtTtKNrrntQakLElkKYD

Chain	Residue	Details
1	TYR22-ASP41

site_id	PS00783
Number of Residues	23
Details	RIBOSOMAL_L13 Ribosomal protein L13 signature. VFGMLPkgrq.GRamhtrLkVYaG

Chain	Residue	Details
G	VAL131-GLY153

site_id	PS00474
Number of Residues	24
Details	RIBOSOMAL_L3 Ribosomal protein L3 signature. FaegekiDatGtSkGKGtqGvmkR

Chain	Residue	Details
B	PHE96-ARG119

site_id	PS00936
Number of Residues	27
Details	RIBOSOMAL_L35 Ribosomal protein L35 signature. KTHkMAkRRIkitgtgkvmafksgk.RH

Chain	Residue	Details
3	LYS5-HIS31

site_id	PS00579
Number of Residues	15
Details	RIBOSOMAL_L29 Ribosomal protein L29 signature. QPHRVRqLRREVAQL

Chain	Residue	Details
V	GLN39-LEU53

site_id	PS00586
Number of Residues	12
Details	RIBOSOMAL_L16_1 Ribosomal protein L16 signature 1. RRgGKIYIRIFP

Chain	Residue	Details
J	ARG60-PRO71

site_id	PS00701
Number of Residues	12
Details	RIBOSOMAL_L16_2 Ribosomal protein L16 signature 2. RMGkGKGaveyW

Chain	Residue	Details
J	ARG83-TRP94

site_id	PS00475
Number of Residues	31
Details	RIBOSOMAL_L15 Ribosomal protein L15 signature. KLLAsGeIsra..VtVhvdaASaaAikaVeaaG

Chain	Residue	Details
I	LYS107-GLY137

site_id	PS00050
Number of Residues	16
Details	RIBOSOMAL_L23 Ribosomal protein L23 signature. KKAIVRLAegqsieaL

Chain	Residue	Details
Q	LYS76-LEU91

site_id	PS00467
Number of Residues	12
Details	RIBOSOMAL_L2 Ribosomal protein L2 signature. PhqRGSAmNPvD

Chain	Residue	Details
A	PRO219-ASP230

site_id	PS00831
Number of Residues	15
Details	RIBOSOMAL_L27 Ribosomal protein L27 signature. GnILvRQRGtkfkaG

Chain	Residue	Details
T	GLY34-GLY48

site_id	PS00937
Number of Residues	17
Details	RIBOSOMAL_L20 Ribosomal protein L20 signature. KrdfRrLWIQRINagaR

Chain	Residue	Details
N	LYS54-ARG70

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: 4-hydroxyglutamate => ECO:0000269\|PubMed:18406324, ECO:0000269\|PubMed:19678698, ECO:0000269\|PubMed:2584148, ECO:0000269\|PubMed:893891

Chain	Residue	Details
5	3GL6
4	CYS14
4	CYS27
4	HIS32

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Serine amide; atypical => ECO:0000269\|PubMed:18406324, ECO:0000269\|PubMed:21047073, ECO:0000269\|PubMed:2584148, ECO:0000269\|PubMed:893891

Chain	Residue	Details
5	DHA12
Y	CYS36
Y	CYS46
Y	CYS49

site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Thiazole-4-carboxylic acid (Ser-Cys) => ECO:0000269\|PubMed:18406324, ECO:0000269\|PubMed:2584148, ECO:0000269\|PubMed:893891

Chain	Residue	Details
5	MH610
5	BB92
5	BB911
5	SER1

site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Thiazole-4-carboxylic acid (Cys-Cys) => ECO:0000269\|PubMed:18406324, ECO:0000269\|PubMed:2584148, ECO:0000269\|PubMed:893891

Chain	Residue	Details
5	BB99
5	CYS8

site_id	SWS_FT_FI5
Number of Residues	2
Details	CROSSLNK: Thiazole-4-carboxylic acid (Thr-Cys) => ECO:0000269\|PubMed:18406324, ECO:0000269\|PubMed:2584148, ECO:0000269\|PubMed:893891

Chain	Residue	Details
5	DBU4
5	BB95

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Thiazole-4-carboxylic acid (Glu-Cys) => ECO:0000269\|PubMed:18406324, ECO:0000269\|PubMed:2584148, ECO:0000269\|PubMed:893891

Chain	Residue	Details
5	3GL6
5	BB97

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)