2YMD
Crystal structure of a mutant binding protein (5HTBP-AChBP) in complex with serotonin (5-hydroxytryptamine)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004888 | molecular_function | transmembrane signaling receptor activity |
| F | 0005216 | molecular_function | monoatomic ion channel activity |
| F | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0006811 | biological_process | monoatomic ion transport |
| F | 0016020 | cellular_component | membrane |
| F | 0034220 | biological_process | monoatomic ion transmembrane transport |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0004888 | molecular_function | transmembrane signaling receptor activity |
| G | 0005216 | molecular_function | monoatomic ion channel activity |
| G | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0006811 | biological_process | monoatomic ion transport |
| G | 0016020 | cellular_component | membrane |
| G | 0034220 | biological_process | monoatomic ion transmembrane transport |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0004888 | molecular_function | transmembrane signaling receptor activity |
| H | 0005216 | molecular_function | monoatomic ion channel activity |
| H | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0006811 | biological_process | monoatomic ion transport |
| H | 0016020 | cellular_component | membrane |
| H | 0034220 | biological_process | monoatomic ion transmembrane transport |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0004888 | molecular_function | transmembrane signaling receptor activity |
| I | 0005216 | molecular_function | monoatomic ion channel activity |
| I | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| I | 0005515 | molecular_function | protein binding |
| I | 0006811 | biological_process | monoatomic ion transport |
| I | 0016020 | cellular_component | membrane |
| I | 0034220 | biological_process | monoatomic ion transmembrane transport |
| I | 0042802 | molecular_function | identical protein binding |
| I | 0046872 | molecular_function | metal ion binding |
| J | 0004888 | molecular_function | transmembrane signaling receptor activity |
| J | 0005216 | molecular_function | monoatomic ion channel activity |
| J | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| J | 0005515 | molecular_function | protein binding |
| J | 0006811 | biological_process | monoatomic ion transport |
| J | 0016020 | cellular_component | membrane |
| J | 0034220 | biological_process | monoatomic ion transmembrane transport |
| J | 0042802 | molecular_function | identical protein binding |
| J | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 1211 |
| Chain | Residue |
| B | HOH2289 |
| B | HOH2290 |
| B | HOH2293 |
| C | PRO96 |
| C | VAL97 |
| D | VAL99 |
| D | LEU100 |
| D | SER101 |
| D | PRO102 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL D 1213 |
| Chain | Residue |
| D | HOH2279 |
| D | HOH2280 |
| D | HOH2282 |
| D | HOH2283 |
| H | PRO96 |
| H | VAL97 |
| I | VAL99 |
| I | LEU100 |
| I | SER101 |
| I | PRO102 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SRO A 1213 |
| Chain | Residue |
| A | TYR91 |
| A | TRP145 |
| A | VAL146 |
| A | CYS188 |
| A | CYS189 |
| A | TYR193 |
| A | HOH2243 |
| B | ILE104 |
| B | VAL106 |
| B | MET114 |
| B | ILE116 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL F 1213 |
| Chain | Residue |
| F | GLU47 |
| F | ARG95 |
| F | GOL1217 |
| F | HOH2099 |
| F | HOH2109 |
| G | LYS40 |
| G | ARG120 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SRO B 1212 |
| Chain | Residue |
| B | TYR91 |
| B | TRP145 |
| B | VAL146 |
| B | CYS188 |
| B | CYS189 |
| B | TYR193 |
| B | HOH2222 |
| C | ILE104 |
| C | VAL106 |
| C | MET114 |
| C | ILE116 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SRO C 1213 |
| Chain | Residue |
| C | TYR91 |
| C | TRP145 |
| C | VAL146 |
| C | CYS188 |
| C | CYS189 |
| C | TYR193 |
| C | HOH2214 |
| C | HOH2279 |
| D | ILE104 |
| D | VAL106 |
| D | ILE116 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SRO D 1214 |
| Chain | Residue |
| D | TYR91 |
| D | TRP145 |
| D | VAL146 |
| D | CYS188 |
| D | CYS189 |
| D | TYR193 |
| D | HOH2284 |
| E | ILE104 |
| E | VAL106 |
| E | MET114 |
| E | ILE116 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SRO E 1213 |
| Chain | Residue |
| A | ILE104 |
| A | VAL106 |
| A | MET114 |
| A | ILE116 |
| A | HOH2213 |
| E | TYR91 |
| E | TRP145 |
| E | VAL146 |
| E | CYS188 |
| E | CYS189 |
| E | TYR193 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SRO F 1214 |
| Chain | Residue |
| F | TYR91 |
| F | TRP145 |
| F | VAL146 |
| F | CYS188 |
| F | CYS189 |
| F | TYR193 |
| F | HOH2269 |
| G | ILE104 |
| G | VAL106 |
| G | MET114 |
| G | ILE116 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SRO G 1213 |
| Chain | Residue |
| H | ILE116 |
| G | TYR91 |
| G | TRP145 |
| G | VAL146 |
| G | CYS188 |
| G | TYR193 |
| G | HOH2193 |
| H | ILE104 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SRO H 1206 |
| Chain | Residue |
| H | TYR91 |
| H | TRP145 |
| H | VAL146 |
| H | CYS188 |
| H | CYS189 |
| H | TYR193 |
| H | HOH2202 |
| I | ILE104 |
| I | VAL106 |
| I | MET114 |
| I | ILE116 |
| site_id | BC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SRO I 1213 |
| Chain | Residue |
| I | TYR91 |
| I | TRP145 |
| I | VAL146 |
| I | CYS188 |
| I | CYS189 |
| I | TYR193 |
| I | HOH2270 |
| J | ILE104 |
| J | VAL106 |
| J | MET114 |
| J | ILE116 |
| site_id | BC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SRO J 1213 |
| Chain | Residue |
| F | ILE104 |
| F | VAL106 |
| F | MET114 |
| F | ILE116 |
| F | HOH2192 |
| J | TYR91 |
| J | TRP145 |
| J | VAL146 |
| J | CYS188 |
| J | CYS189 |
| J | TYR193 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 1215 |
| Chain | Residue |
| C | ARG95 |
| D | LYS40 |
| D | ASP49 |
| D | SER122 |
| D | HOH2098 |
| D | HOH2100 |
| D | HOH2101 |
| D | HOH2285 |
| site_id | BC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL C 1214 |
| Chain | Residue |
| C | PRO19 |
| C | TRP84 |
| C | TYR147 |
| C | HOH2042 |
| C | HOH2163 |
| C | HOH2280 |
| C | HOH2281 |
| D | LYS8 |
| D | THR78 |
| D | SER79 |
| site_id | BC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL F 1215 |
| Chain | Residue |
| F | PRO19 |
| F | TRP84 |
| F | TYR147 |
| F | HOH2041 |
| F | HOH2045 |
| F | HOH2162 |
| F | HOH2271 |
| G | LYS8 |
| G | THR78 |
| G | SER79 |
| site_id | BC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL E 1214 |
| Chain | Residue |
| A | LYS8 |
| A | THR78 |
| A | SER79 |
| A | HOH2018 |
| A | HOH2019 |
| E | PRO19 |
| E | TRP84 |
| E | TYR147 |
| E | HOH2139 |
| E | HOH2225 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 1216 |
| Chain | Residue |
| C | ASP24 |
| C | HOH2050 |
| C | HOH2058 |
| D | GLN1 |
| D | ALA2 |
| D | ASN3 |
| D | LEU4 |
| D | HOH2001 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1214 |
| Chain | Residue |
| A | PRO19 |
| A | TRP84 |
| A | THR85 |
| A | TYR147 |
| A | HOH2182 |
| A | HOH2302 |
| site_id | CC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 1213 |
| Chain | Residue |
| A | ARG95 |
| A | HOH2196 |
| B | LYS40 |
| B | ASP49 |
| B | SER122 |
| B | GOL1215 |
| B | HOH2105 |
| B | HOH2295 |
| site_id | CC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1215 |
| Chain | Residue |
| A | LYS23 |
| A | SER148 |
| A | GLU151 |
| A | GLU191 |
| A | HOH2292 |
| B | ASP75 |
| B | ARG77 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 1214 |
| Chain | Residue |
| B | SER148 |
| B | PHE150 |
| B | GLU151 |
| B | GLU191 |
| B | HOH2297 |
| C | ARG77 |
| site_id | CC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 C 1215 |
| Chain | Residue |
| C | LYS23 |
| C | SER148 |
| C | PHE150 |
| C | GLU151 |
| C | GLU191 |
| C | HOH2270 |
| D | ARG77 |
| site_id | CC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 D 1217 |
| Chain | Residue |
| D | LYS23 |
| D | SER148 |
| D | PHE150 |
| D | GLU151 |
| D | GLU191 |
| D | HOH2046 |
| D | HOH2266 |
| E | ARG77 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 E 1215 |
| Chain | Residue |
| A | ARG77 |
| A | HOH2167 |
| E | LYS23 |
| E | SER148 |
| E | GLU151 |
| E | GLU191 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 F 1216 |
| Chain | Residue |
| F | LYS23 |
| F | SER148 |
| F | PHE150 |
| F | GLU151 |
| F | GLU191 |
| F | HOH2261 |
| G | ARG77 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 G 1214 |
| Chain | Residue |
| G | LYS23 |
| G | SER148 |
| G | GLU151 |
| G | GLU191 |
| G | HOH2238 |
| H | ARG77 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 H 1207 |
| Chain | Residue |
| H | SER148 |
| H | PHE150 |
| H | GLU151 |
| H | GLU191 |
| H | HOH2207 |
| I | ARG77 |
| site_id | DC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 I 1214 |
| Chain | Residue |
| I | LYS23 |
| I | SER148 |
| I | PHE150 |
| I | GLU151 |
| I | GLU191 |
| I | HOH2260 |
| J | ARG77 |
| site_id | DC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 J 1214 |
| Chain | Residue |
| F | ARG77 |
| F | HOH2146 |
| F | HOH2148 |
| F | HOH2151 |
| J | SER148 |
| J | GLU151 |
| J | GLU191 |
| site_id | DC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL G 1215 |
| Chain | Residue |
| F | ARG95 |
| G | LYS40 |
| G | ASP49 |
| G | ARG95 |
| G | ARG120 |
| G | SER122 |
| G | HOH2093 |
| site_id | DC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL F 1217 |
| Chain | Residue |
| F | LYS40 |
| F | ASP49 |
| F | SER122 |
| F | GOL1213 |
| F | HOH2098 |
| F | HOH2109 |
| F | HOH2272 |
| J | ARG95 |
| site_id | DC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1215 |
| Chain | Residue |
| B | GLU47 |
| B | ARG95 |
| B | SER122 |
| B | GOL1213 |
| B | HOH2092 |
| C | LYS40 |
| C | ARG120 |
| site_id | DC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL J 1215 |
| Chain | Residue |
| F | LYS40 |
| F | ARG120 |
| J | GLU47 |
| J | ARG95 |
| J | HOH2077 |
| J | HOH2082 |
