2YDX
Crystal structure of human S-adenosylmethionine synthetase 2, beta subunit
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005829 | cellular_component | cytosol |
A | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0019899 | molecular_function | enzyme binding |
A | 0048269 | cellular_component | methionine adenosyltransferase complex |
A | 0048270 | molecular_function | methionine adenosyltransferase regulator activity |
A | 0070062 | cellular_component | extracellular exosome |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005829 | cellular_component | cytosol |
B | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0019899 | molecular_function | enzyme binding |
B | 0048269 | cellular_component | methionine adenosyltransferase complex |
B | 0048270 | molecular_function | methionine adenosyltransferase regulator activity |
B | 0070062 | cellular_component | extracellular exosome |
C | 0005515 | molecular_function | protein binding |
C | 0005634 | cellular_component | nucleus |
C | 0005829 | cellular_component | cytosol |
C | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
C | 0006730 | biological_process | one-carbon metabolic process |
C | 0019899 | molecular_function | enzyme binding |
C | 0048269 | cellular_component | methionine adenosyltransferase complex |
C | 0048270 | molecular_function | methionine adenosyltransferase regulator activity |
C | 0070062 | cellular_component | extracellular exosome |
D | 0005515 | molecular_function | protein binding |
D | 0005634 | cellular_component | nucleus |
D | 0005829 | cellular_component | cytosol |
D | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
D | 0006730 | biological_process | one-carbon metabolic process |
D | 0019899 | molecular_function | enzyme binding |
D | 0048269 | cellular_component | methionine adenosyltransferase complex |
D | 0048270 | molecular_function | methionine adenosyltransferase regulator activity |
D | 0070062 | cellular_component | extracellular exosome |
E | 0005515 | molecular_function | protein binding |
E | 0005634 | cellular_component | nucleus |
E | 0005829 | cellular_component | cytosol |
E | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
E | 0006730 | biological_process | one-carbon metabolic process |
E | 0019899 | molecular_function | enzyme binding |
E | 0048269 | cellular_component | methionine adenosyltransferase complex |
E | 0048270 | molecular_function | methionine adenosyltransferase regulator activity |
E | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE STL A 501 |
Chain | Residue |
A | TRP328 |
C | ALA77 |
C | HIS80 |
C | ASP84 |
A | ARG329 |
A | THR331 |
A | VAL332 |
A | HIS334 |
A | GLU336 |
A | ASN337 |
C | GLU68 |
C | ASN76 |
site_id | AC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE STL A 502 |
Chain | Residue |
A | ARG97 |
A | SER136 |
A | ASP137 |
A | TYR138 |
A | TYR159 |
A | ILE184 |
A | GLU193 |
A | SER195 |
A | ALA196 |
A | ARG219 |
A | NAP1339 |
site_id | AC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE STL B 501 |
Chain | Residue |
B | SER136 |
B | ASP137 |
B | TYR159 |
B | ILE184 |
B | GLU193 |
B | SER195 |
B | ALA196 |
B | ARG219 |
B | NAP1339 |
B | SO41342 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE STL B 502 |
Chain | Residue |
B | GLU68 |
B | ASN76 |
B | ALA77 |
B | HIS80 |
B | ASP84 |
B | TRP328 |
B | ARG329 |
B | THR331 |
B | VAL332 |
B | HIS334 |
B | GLU336 |
B | ASN337 |
site_id | AC5 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE STL C 501 |
Chain | Residue |
A | GLU68 |
A | ASN76 |
A | HIS80 |
A | ASP84 |
C | TRP328 |
C | ARG329 |
C | THR331 |
C | HIS334 |
C | GLU336 |
C | ASN337 |
C | HOH2095 |
site_id | AC6 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE STL C 502 |
Chain | Residue |
C | ARG97 |
C | SER136 |
C | ASP137 |
C | TYR159 |
C | ILE184 |
C | GLU193 |
C | SER195 |
C | ALA196 |
C | ARG219 |
C | NAP1339 |
C | SO41340 |
site_id | AC7 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE STL D 501 |
Chain | Residue |
D | ARG97 |
D | SER136 |
D | ASP137 |
D | TYR159 |
D | ILE184 |
D | GLU193 |
D | SER195 |
D | ALA196 |
D | ARG219 |
D | NAP1339 |
D | SO41341 |
site_id | AC8 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE STL D 502 |
Chain | Residue |
D | TRP328 |
D | ARG329 |
D | THR331 |
D | VAL332 |
D | HIS334 |
D | GLU336 |
D | ASN337 |
E | GLU68 |
E | ASP74 |
E | ASN76 |
E | ALA77 |
E | HIS80 |
E | ASP84 |
site_id | AC9 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE STL E 501 |
Chain | Residue |
E | ARG219 |
E | TXP1339 |
E | ARG97 |
E | ARG98 |
E | SER136 |
E | ASP137 |
E | TYR159 |
E | ILE184 |
E | GLU193 |
E | ALA196 |
site_id | BC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE STL E 502 |
Chain | Residue |
D | GLU68 |
D | ASP74 |
D | ASN76 |
D | ALA77 |
D | HIS80 |
D | ASP84 |
E | TRP328 |
E | ARG329 |
E | THR331 |
E | HIS334 |
E | GLU336 |
E | ASN337 |
site_id | BC2 |
Number of Residues | 33 |
Details | BINDING SITE FOR RESIDUE NAP A 1339 |
Chain | Residue |
A | GLY35 |
A | THR37 |
A | GLY38 |
A | LEU39 |
A | LEU40 |
A | PHE60 |
A | ARG61 |
A | ARG62 |
A | VAL70 |
A | ASN71 |
A | LEU72 |
A | CYS93 |
A | ALA94 |
A | ALA95 |
A | ARG97 |
A | LEU112 |
A | ILE134 |
A | SER135 |
A | TYR159 |
A | LYS163 |
A | ILE182 |
A | PRO183 |
A | ILE184 |
A | LEU185 |
A | STL502 |
A | HOH2006 |
A | HOH2025 |
A | HOH2071 |
A | HOH2148 |
A | HOH2149 |
A | HOH2150 |
A | HOH2151 |
A | HOH2152 |
site_id | BC3 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE NAP D 1339 |
Chain | Residue |
D | GLY35 |
D | THR37 |
D | GLY38 |
D | LEU39 |
D | LEU40 |
D | PHE60 |
D | ARG61 |
D | ARG62 |
D | VAL70 |
D | ASN71 |
D | LEU72 |
D | CYS93 |
D | ALA94 |
D | ALA95 |
D | ARG97 |
D | LEU112 |
D | ILE134 |
D | SER135 |
D | TYR159 |
D | LYS163 |
D | ILE182 |
D | PRO183 |
D | LEU185 |
D | STL501 |
D | HOH2004 |
D | HOH2017 |
D | HOH2063 |
D | HOH2064 |
site_id | BC4 |
Number of Residues | 32 |
Details | BINDING SITE FOR RESIDUE NAP C 1339 |
Chain | Residue |
C | GLY35 |
C | THR37 |
C | GLY38 |
C | LEU39 |
C | LEU40 |
C | PHE60 |
C | ARG61 |
C | ARG62 |
C | VAL70 |
C | ASN71 |
C | LEU72 |
C | CYS93 |
C | ALA94 |
C | ALA95 |
C | ARG97 |
C | LEU112 |
C | ILE134 |
C | SER135 |
C | TYR159 |
C | LYS163 |
C | ILE182 |
C | PRO183 |
C | ILE184 |
C | LEU185 |
C | STL502 |
C | HOH2047 |
C | HOH2096 |
C | HOH2097 |
C | HOH2098 |
C | HOH2099 |
C | HOH2100 |
C | HOH2101 |
site_id | BC5 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE TXP E 1339 |
Chain | Residue |
E | GLY35 |
E | THR37 |
E | GLY38 |
E | LEU39 |
E | LEU40 |
E | PHE60 |
E | ARG61 |
E | ARG62 |
E | VAL70 |
E | ASN71 |
E | LEU72 |
E | CYS93 |
E | ALA94 |
E | ALA95 |
E | ARG97 |
E | LEU112 |
E | ILE134 |
E | SER135 |
E | TYR159 |
E | LYS163 |
E | ILE182 |
E | PRO183 |
E | LEU185 |
E | STL501 |
E | HOH2003 |
E | HOH2064 |
site_id | BC6 |
Number of Residues | 32 |
Details | BINDING SITE FOR RESIDUE NAP B 1339 |
Chain | Residue |
B | GLY35 |
B | THR37 |
B | GLY38 |
B | LEU39 |
B | LEU40 |
B | PHE60 |
B | ARG61 |
B | ARG62 |
B | VAL70 |
B | ASN71 |
B | LEU72 |
B | CYS93 |
B | ALA94 |
B | ALA95 |
B | ARG97 |
B | LEU112 |
B | ILE134 |
B | SER135 |
B | TYR159 |
B | LYS163 |
B | ILE182 |
B | PRO183 |
B | LEU185 |
B | STL501 |
B | HOH2004 |
B | HOH2005 |
B | HOH2039 |
B | HOH2067 |
B | HOH2122 |
B | HOH2125 |
B | HOH2126 |
B | HOH2127 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 E 1340 |
Chain | Residue |
C | ARG30 |
C | HIS88 |
E | ARG30 |
E | HIS88 |
site_id | BC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 1340 |
Chain | Residue |
A | ARG30 |
A | HIS88 |
A | HOH2153 |
A | HOH2154 |
D | ARG30 |
D | HIS88 |
site_id | BC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 B 1340 |
Chain | Residue |
B | ARG30 |
B | HIS88 |
site_id | CC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 C 1340 |
Chain | Residue |
C | TYR138 |
C | ARG219 |
C | ARG289 |
C | STL502 |
C | HOH2102 |
C | HOH2103 |
site_id | CC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 E 1341 |
Chain | Residue |
E | GLN218 |
E | GLN255 |
E | ARG291 |
E | ASN292 |
site_id | CC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 1341 |
Chain | Residue |
C | GLN218 |
C | GLN255 |
C | ARG291 |
C | ASN292 |
site_id | CC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 1341 |
Chain | Residue |
B | GLN218 |
B | GLN255 |
B | ARG291 |
B | ASN292 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 1340 |
Chain | Residue |
D | GLN218 |
D | GLN255 |
D | ARG291 |
D | ASN292 |
site_id | CC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 1342 |
Chain | Residue |
B | TYR138 |
B | ALA196 |
B | ARG219 |
B | LYS258 |
B | ARG289 |
B | STL501 |
site_id | CC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 1341 |
Chain | Residue |
A | ARG327 |
A | TRP328 |
A | ARG329 |
C | HIS54 |
C | VAL56 |
site_id | CC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 D 1341 |
Chain | Residue |
D | TYR138 |
D | ALA196 |
D | ARG219 |
D | LYS258 |
D | ARG289 |
D | STL501 |
site_id | CC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 B 1343 |
Chain | Residue |
B | PHE220 |
B | SER251 |
B | GLY252 |
B | ASN253 |
B | GLN294 |
B | LEU295 |
B | ARG308 |
site_id | DC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 1342 |
Chain | Residue |
A | SER251 |
A | GLY252 |
A | ASN253 |
A | GLN294 |
A | LEU295 |
A | ARG308 |
A | HOH2155 |
site_id | DC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 1344 |
Chain | Residue |
B | HIS54 |
B | ARG327 |
B | TRP328 |
B | ARG329 |
site_id | DC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 C 1342 |
Chain | Residue |
A | HIS54 |
A | VAL56 |
C | ARG327 |
C | TRP328 |
C | ARG329 |
site_id | DC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 D 1342 |
Chain | Residue |
D | ARG327 |
D | TRP328 |
D | ARG329 |
E | HIS54 |
E | VAL56 |
E | HOH2017 |
site_id | DC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 E 1342 |
Chain | Residue |
D | HIS54 |
D | VAL56 |
E | ARG327 |
E | TRP328 |
E | ARG329 |
site_id | DC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 E 1343 |
Chain | Residue |
E | TYR138 |
E | ARG219 |
E | LYS258 |
E | ARG289 |
site_id | DC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 1343 |
Chain | Residue |
A | TYR138 |
A | HOH2156 |
site_id | DC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 1344 |
Chain | Residue |
A | ASP137 |
A | PRO183 |
A | PHE220 |
A | HOH2086 |
A | HOH2098 |
A | HOH2125 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 35 |
Details | BINDING: BINDING => ECO:0007744|PDB:2YDX |
Chain | Residue | Details |
A | THR37 | |
B | ASN71 | |
B | CYS93 | |
B | ARG97 | |
B | TYR159 | |
B | LEU185 | |
C | THR37 | |
C | PHE60 | |
C | ASN71 | |
C | CYS93 | |
C | ARG97 | |
A | PHE60 | |
C | TYR159 | |
C | LEU185 | |
D | THR37 | |
D | PHE60 | |
D | ASN71 | |
D | CYS93 | |
D | ARG97 | |
D | TYR159 | |
D | LEU185 | |
E | THR37 | |
A | ASN71 | |
E | PHE60 | |
E | ASN71 | |
E | CYS93 | |
E | ARG97 | |
E | TYR159 | |
E | LEU185 | |
A | CYS93 | |
A | ARG97 | |
A | TYR159 | |
A | LEU185 | |
B | THR37 | |
B | PHE60 |
site_id | SWS_FT_FI2 |
Number of Residues | 5 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | THR309 | |
B | THR309 | |
C | THR309 | |
D | THR309 | |
E | THR309 |