2Y7H
Atomic model of the DNA-bound methylase complex from the Type I restriction-modification enzyme EcoKI (M2S1). Based on fitting into EM map 1534.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0009307 | biological_process | DNA restriction-modification system |
| A | 0019812 | cellular_component | type I site-specific deoxyribonuclease complex |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008170 | molecular_function | N-methyltransferase activity |
| B | 0009007 | molecular_function | site-specific DNA-methyltransferase (adenine-specific) activity |
| B | 0009307 | biological_process | DNA restriction-modification system |
| B | 0032259 | biological_process | methylation |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0008170 | molecular_function | N-methyltransferase activity |
| C | 0009007 | molecular_function | site-specific DNA-methyltransferase (adenine-specific) activity |
| C | 0009307 | biological_process | DNA restriction-modification system |
| C | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SAM B 530 |
| Chain | Residue |
| B | GLN148 |
| B | ASN248 |
| B | THR249 |
| B | ASN266 |
| B | PRO268 |
| B | THR275 |
| B | PHE292 |
| D | DA6 |
| B | TYR149 |
| B | THR151 |
| B | ALA175 |
| B | GLY177 |
| B | THR178 |
| B | GLY180 |
| B | PHE181 |
| B | GLU216 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE SAM C 530 |
| Chain | Residue |
| C | GLN148 |
| C | TYR149 |
| C | THR151 |
| C | ALA175 |
| C | GLY177 |
| C | THR178 |
| C | GLY180 |
| C | PHE181 |
| C | GLU216 |
| C | ASN248 |
| C | THR249 |
| C | ASN266 |
| C | PRO268 |
| C | THR275 |
| E | DA6 |
Functional Information from PROSITE/UniProt
| site_id | PS00092 |
| Number of Residues | 7 |
| Details | N6_MTASE N-6 Adenine-specific DNA methylases signature. VATNPPF |
| Chain | Residue | Details |
| B | VAL263-PHE269 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q89Z59","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
