2XZO

Upf1 helicase - RNA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 1PE B 1

Chain	Residue
A	ASN472
A	HIS473
A	SER474
A	THR496
A	LEU698
A	GLN699
A	VAL700
A	TYR702

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE B 2

Chain	Residue
A	THR464
A	ALA465
A	GLN466
A	HOH1189
A	ARG462

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE B 6

Chain	Residue
A	ASP421
A	ARG422
A	SER425
A	ALA426
A	GLY621
A	HOH1102

---

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP E 480

Chain	Residue
A	PRO469
A	ASP470
A	ASN472
A	GLN475
A	GLY495
A	THR496
A	GLY497
A	LYS498
A	THR499
A	VAL500
A	TYR702
A	ARG703
A	GLU833
A	HOH1128
A	ALF1005
A	MG1006
A	HOH1119
A	HOH1134

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ALF E 481

Chain	Residue
A	PRO494
A	GLY495
A	LYS498
A	GLU637
A	GLN665
A	ARG703
A	GLY831
A	ARG865
A	HOH1195
A	HOH1104
A	ADP1004
A	MG1006

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG E 482

Chain	Residue
A	THR499
A	HOH1195
A	HOH1106
A	ADP1004
A	ALF1005
A	HOH1119

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG E 483

Chain	Residue
A	TYR806
A	MET807
A	PHE809
A	SER810
A	SER812
A	THR815

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	212
Details	Domain: {"description":"UPF1-type SF1B helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01433","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17159905","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21419344","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2GJK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GK6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21419344","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2GJK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GK6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21419344","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2GK6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21419344","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2XZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17159905","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GJK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GK6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17159905","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21419344","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2GJK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21419344","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2GJK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---