2XW9
Crystal Structure of Complement Factor D mutant S183A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002376 | biological_process | immune system process |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0006956 | biological_process | complement activation |
| A | 0006957 | biological_process | complement activation, alternative pathway |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0009617 | biological_process | response to bacterium |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0031093 | cellular_component | platelet alpha granule lumen |
| A | 0031638 | biological_process | zymogen activation |
| A | 0034774 | cellular_component | secretory granule lumen |
| A | 0045087 | biological_process | innate immune response |
| A | 0051604 | biological_process | protein maturation |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1230 |
| Chain | Residue |
| A | ASP116 |
| A | VAL117 |
| A | VAL148 |
| A | LEU149 |
| A | ASP150 |
| A | ARG151 |
| A | MET169 |
| A | CYS170 |
| A | HOH2298 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL A 1231 |
| Chain | Residue |
| A | SER178 |
| A | CYS179 |
| A | VAL197 |
| A | THR198 |
| A | GLY200 |
| A | ARG202 |
| A | GOL1232 |
| A | HOH2266 |
| A | HOH2269 |
| A | HOH2299 |
| A | HOH2300 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1232 |
| Chain | Residue |
| A | LYS180 |
| A | SER201 |
| A | ARG202 |
| A | CYS204 |
| A | GOL1231 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1233 |
| Chain | Residue |
| A | HIS159 |
| A | GLU172 |
| A | ARG207 |
| A | HOH2301 |
| site_id | CAT |
| Number of Residues | 3 |
| Details | CATALYTIC SITE SHOWS FLIPPED HIS 41 DUE TO SELF-INHIBITORY LOOP |
| Chain | Residue |
| A | HIS41 |
| A | ASP89 |
| A | SER199 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC |
| Chain | Residue | Details |
| A | LEU37-CYS42 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 227 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Region: {"description":"Self-inhibitor loop","evidences":[{"source":"PubMed","id":"10022823","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9753554","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"7592653","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9753554","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"7592653","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"7592653","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21205667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22362762","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
