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2XRL

Tet-repressor class D T103A with doxycycline

Functional Information from GO Data
ChainGOidnamespacecontents
A0000976molecular_functiontranscription cis-regulatory region binding
A0003677molecular_functionDNA binding
A0003700molecular_functionDNA-binding transcription factor activity
A0006351biological_processDNA-templated transcription
A0006355biological_processregulation of DNA-templated transcription
A0045892biological_processnegative regulation of DNA-templated transcription
A0046677biological_processresponse to antibiotic
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL A 1209
ChainResidue
AARG3
ALEU4
AGLN76
AARG80
AHOH2095

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 1210
ChainResidue
AARG3
ASER74
ASER77

site_idAC3
Number of Residues16
DetailsBINDING SITE FOR RESIDUE DXT A 1211
ChainResidue
ASER67
AASN82
APHE86
AHIS100
AARG104
APRO105
AVAL113
AGLN116
AILE134
ASER138
ALEU174
AMG1212
AHOH1214
AHOH1215
AHOH2105
AHIS64

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1212
ChainResidue
AHIS100
ADXT1211
AHOH1213
AHOH1214
AHOH1215

Functional Information from PROSITE/UniProt
site_idPS01081
Number of Residues32
DetailsHTH_TETR_1 TetR-type HTH domain signature. GIdglTTrkLaqklgIEqPtLYwHVkNKralL
ChainResidueDetails
AGLY21-LEU52

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues60
DetailsDomain: {"description":"HTH tetR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues19
DetailsDNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"8153629","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2TRT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246333

PDB entries from 2025-12-17

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