Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2XMN

High resolution snapshots of defined TolC open states present an iris- like movement of periplasmic entrance helices

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005515	molecular_function	protein binding
A	0009279	cellular_component	cell outer membrane
A	0009410	biological_process	response to xenobiotic stimulus
A	0009636	biological_process	response to toxic substance
A	0015125	molecular_function	bile acid transmembrane transporter activity
A	0015288	molecular_function	porin activity
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0016020	cellular_component	membrane
A	0019867	cellular_component	outer membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0042930	biological_process	enterobactin transport
A	0042931	molecular_function	enterobactin transmembrane transporter activity
A	0046677	biological_process	response to antibiotic
A	0055085	biological_process	transmembrane transport
A	0098567	cellular_component	periplasmic side of plasma membrane
A	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
A	1990196	cellular_component	MacAB-TolC complex
A	1990281	cellular_component	efflux pump complex
A	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
B	0005216	molecular_function	monoatomic ion channel activity
B	0005515	molecular_function	protein binding
B	0009279	cellular_component	cell outer membrane
B	0009410	biological_process	response to xenobiotic stimulus
B	0009636	biological_process	response to toxic substance
B	0015125	molecular_function	bile acid transmembrane transporter activity
B	0015288	molecular_function	porin activity
B	0015562	molecular_function	efflux transmembrane transporter activity
B	0015721	biological_process	bile acid and bile salt transport
B	0016020	cellular_component	membrane
B	0019867	cellular_component	outer membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0042930	biological_process	enterobactin transport
B	0042931	molecular_function	enterobactin transmembrane transporter activity
B	0046677	biological_process	response to antibiotic
B	0055085	biological_process	transmembrane transport
B	0098567	cellular_component	periplasmic side of plasma membrane
B	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
B	1990196	cellular_component	MacAB-TolC complex
B	1990281	cellular_component	efflux pump complex
B	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
C	0005216	molecular_function	monoatomic ion channel activity
C	0005515	molecular_function	protein binding
C	0009279	cellular_component	cell outer membrane
C	0009410	biological_process	response to xenobiotic stimulus
C	0009636	biological_process	response to toxic substance
C	0015125	molecular_function	bile acid transmembrane transporter activity
C	0015288	molecular_function	porin activity
C	0015562	molecular_function	efflux transmembrane transporter activity
C	0015721	biological_process	bile acid and bile salt transport
C	0016020	cellular_component	membrane
C	0019867	cellular_component	outer membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0042930	biological_process	enterobactin transport
C	0042931	molecular_function	enterobactin transmembrane transporter activity
C	0046677	biological_process	response to antibiotic
C	0055085	biological_process	transmembrane transport
C	0098567	cellular_component	periplasmic side of plasma membrane
C	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
C	1990196	cellular_component	MacAB-TolC complex
C	1990281	cellular_component	efflux pump complex
C	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT B 1429

Chain	Residue
B	ARG35
B	LEU84
B	THR85
B	GLU88

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 1429

Chain	Residue
C	GLN294
C	GLY296
C	VAL298

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1429

Chain	Residue
A	VAL298
A	GLN294
A	GLY296

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 1430

Chain	Residue
B	GLN294
B	GLY296
B	MET297
B	VAL298

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	630
Details	Topological domain: {"description":"Periplasmic"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	33
Details	Transmembrane: {"description":"Beta stranded; Name=S1"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	81
Details	Topological domain: {"description":"Extracellular"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	39
Details	Transmembrane: {"description":"Beta stranded; Name=S2"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	30
Details	Transmembrane: {"description":"Beta stranded; Name=S4"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	30
Details	Transmembrane: {"description":"Beta stranded; Name=S5"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	621
Details	Repeat: {"description":"1"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	645
Details	Repeat: {"description":"2"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	84
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	45
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)