2XHD

Crystal structure of N-((2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H- inden-2-yl)-2-propanesulfonamide in complex with the ligand binding domain of the human GluA2 receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU A 301

Chain	Residue
A	TYR61
A	TYR220
A	HOH2148
A	HOH2205
A	HOH2283
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1264

Chain	Residue
A	SER140
A	LYS144
A	ARG148
A	HOH2150
A	HOH2284
A	HOH2285
A	HOH2286

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1265

Chain	Residue
A	ARG148
A	TRP159
A	ARG163

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 301

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193
B	TYR220
B	HOH2138
B	HOH2185
B	HOH2245

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 1263

Chain	Residue
B	ASP139
B	SER140
B	LYS144
B	ARG148
B	HOH2081
B	HOH2246
B	HOH2247
B	HOH2248

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1264

Chain	Residue
A	LYS183
B	ARG31
B	HOH2040
B	HOH2249
B	HOH2250

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1265

Chain	Residue
B	ARG148
B	TRP159
B	ARG163
B	HOH2251

---

site_id	AC8
Number of Residues	26
Details	BINDING SITE FOR RESIDUE 7T9 B 1266

Chain	Residue
A	LYS104
A	PRO105
A	MET107
A	SER108
A	SER217
A	LYS218
A	GLY219
A	SER242
A	HOH2234
A	HOH2257
B	LYS104
B	PRO105
B	MET107
B	SER108
B	SER217
B	LYS218
B	GLY219
B	SER242
B	HOH3000
B	HOH3001
B	HOH3002
B	HOH3003
B	HOH3004
B	HOH3005
B	HOH3006
B	HOH3007

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Helical => ECO:0000250

Chain	Residue	Details
A	ALA134-VAL154
A	ASP207-GLY227
B	ALA134-VAL154
B	ASP207-GLY227

---

site_id	SWS_FT_FI2
Number of Residues	62
Details	TOPO_DOM: Cytoplasmic => ECO:0000250

Chain	Residue	Details
A	PHE155-VAL181
A	GLU201-CYS206
B	PHE155-VAL181
B	GLU201-CYS206

---

site_id	SWS_FT_FI3
Number of Residues	30
Details	INTRAMEM: Helical; Pore-forming => ECO:0000250

Chain	Residue	Details
A	ARG182-ASN197
B	ARG182-ASN197

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	INTRAMEM: INTRAMEM => ECO:0000250

Chain	Residue	Details
A	GLU198-ILE200
B	GLU198-ILE200

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:20614889, ECO:0007744|PDB:2XHD

Chain	Residue	Details
A	PRO89
A	THR91
A	SER142
A	THR143
B	PRO89
B	THR91
B	SER142
B	THR143

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:20614889, ECO:0000269|PubMed:21531559, ECO:0007744|PDB:2XHD, ECO:0007744|PDB:3R7X

Chain	Residue	Details
A	ARG96
B	ARG96

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:20614889, ECO:0000269|PubMed:21531559, ECO:0007744|PDB:2XHD

Chain	Residue	Details
A	GLU193
B	GLU193

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:P19491

Chain	Residue	Details
A	SER150
B	SER150

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000250|UniProtKB:P19491

Chain	Residue	Details
A	SER184
B	SER184

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000250

Chain	Residue	Details
A	ILE200
B	ILE200

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3

---