2XHD
Crystal structure of N-((2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H- inden-2-yl)-2-propanesulfonamide in complex with the ligand binding domain of the human GluA2 receptor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | GLUTAMATE RECEPTOR 2 | polymer | 263 | 29277.8 | 2 | UniProt (P42262) Pfam (PF10613) Pfam (PF00060) In PDB | HOMO SAPIENS (HUMAN) | GLUR-B, GLUR-K2, GLUTAMATE RECEPTOR IONOTROPIC AMPA 2, GLUA2, AMPA-SELECTIVE GLUTAMATE RECEPTOR 2 |
2 | A, B | GLUTAMIC ACID | non-polymer | 147.1 | 2 | Chemie (GLU) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
4 | B | N-[(2S)-5-(6-FLUORO-3-PYRIDINYL)-2,3-DIHYDRO-1H-INDEN-2-YL]-2-PROPANESULFONAMIDE | non-polymer | 334.4 | 1 | Chemie (7T9) | |||
5 | water | water | 18.0 | 545 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 117 (UniProt: P42262)
A, B: 120 - 263 (UniProt: P42262)
A, B: 118 - 119 (PDB: 2XHD)
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Ala 2 | - | expression tag |
Ala 2 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 242 | Asn 775 | variant |
Ser 242 | Asn 775 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 58555.6 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1109.0 | |
All* | Total formula weight | 59664.6 |