2XHD

Crystal structure of N-((2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H- inden-2-yl)-2-propanesulfonamide in complex with the ligand binding domain of the human GluA2 receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	GLUTAMATE RECEPTOR 2	polymer	263	29277.8	2	UniProt (P42262) Pfam (PF10613) Pfam (PF00060)	HOMO SAPIENS (HUMAN)	GLUR-B, GLUR-K2, GLUTAMATE RECEPTOR IONOTROPIC AMPA 2, GLUA2, AMPA-SELECTIVE GLUTAMATE RECEPTOR 2
2	C, F (A, B)	GLUTAMIC ACID	non-polymer		147.1	2	Chemie (GLU)
3	D, E, H, I, J (A, B)	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
4	G (B)	N-[(2S)-5-(6-FLUORO-3-PYRIDINYL)-2,3-DIHYDRO-1H-INDEN-2-YL]-2-PROPANESULFONAMIDE	non-polymer		334.4	1	Chemie (7T9)
5	K, L (A, B)	water	water		18.0	545	Chemie (HOH)

Sequence modifications

A, B: 2 - 117 (UniProt: P42262)

PDB	External Database	Details
Gly 1	-	expression tag
Ala 2	-	expression tag
Ala 2	-	expression tag

A, B: 120 - 263 (UniProt: P42262)

PDB	External Database	Details
Ser 242	Asn 775	variant
Ser 242	Asn 775	variant

A, B: 118 - 119 (PDB: 2XHD)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58555.6
Non-Polymers*	Number of molecules	8
	Total formula weight	1109.0
All*	Total formula weight	59664.6

*Water molecules are not included.