Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0070012 | molecular_function | oligopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1732 |
| Chain | Residue |
| A | PRO591 |
| A | ASP592 |
| A | PHE594 |
| A | GLU650 |
| A | TYR651 |
| A | PRO652 |
| A | PGR1766 |
| A | HOH2610 |
| A | HOH2710 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1733 |
| Chain | Residue |
| A | HIS340 |
| A | VAL341 |
| A | PHE385 |
| A | LYS386 |
| A | ALA387 |
| A | PGR1759 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1734 |
| Chain | Residue |
| A | GLY452 |
| A | HIS480 |
| A | ASP516 |
| A | ARG726 |
| A | LEU727 |
| A | LEU728 |
| A | HOH2479 |
| A | HOH2682 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1735 |
| Chain | Residue |
| A | LYS595 |
| A | ASN653 |
| A | ASN685 |
| A | HIS720 |
| A | PGR1767 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 1736 |
| Chain | Residue |
| A | PHE698 |
| A | HOH2720 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1737 |
| Chain | Residue |
| A | GLN437 |
| A | HIS439 |
| A | HOH2683 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1738 |
| Chain | Residue |
| A | SER311 |
| A | VAL446 |
| A | ARG447 |
| A | GLU448 |
| A | VAL449 |
| A | HOH2362 |
| A | HOH2684 |
| A | HOH2685 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1739 |
| Chain | Residue |
| A | THR466 |
| A | ALA555 |
| A | GLU558 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1740 |
| Chain | Residue |
| A | ARG547 |
| A | SER551 |
| A | MET589 |
| A | ASP635 |
| A | TYR636 |
| A | HOH2546 |
| A | HOH2590 |
| A | HOH2591 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1741 |
| Chain | Residue |
| A | LYS299 |
| A | TYR543 |
| A | TRP622 |
| A | ASN627 |
| A | TYR633 |
| A | HOH2587 |
| A | HOH2686 |
| A | HOH2687 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGR A 1742 |
| Chain | Residue |
| A | GLU574 |
| A | GLY575 |
| A | GLY600 |
| A | GLN713 |
| A | PGO1743 |
| A | HOH2688 |
| A | HOH2706 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGO A 1743 |
| Chain | Residue |
| A | GLN510 |
| A | TYR514 |
| A | GLU574 |
| A | LEU598 |
| A | SER710 |
| A | PGR1742 |
| A | PGR1777 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGR A 1744 |
| Chain | Residue |
| A | HIS308 |
| A | GLY309 |
| A | SER311 |
| A | HIS312 |
| A | ASP454 |
| A | HOH2441 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGR A 1745 |
| Chain | Residue |
| A | ALA700 |
| A | LYS701 |
| A | ARG703 |
| A | PHE706 |
| A | HOH2162 |
| A | HOH2656 |
| site_id | BC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PGR A 1746 |
| Chain | Residue |
| A | TRP50 |
| A | ARG52 |
| A | ASP53 |
| A | PGR1775 |
| A | PGR1780 |
| A | HOH2091 |
| A | HOH2691 |
| A | HOH2700 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGR A 1747 |
| Chain | Residue |
| A | ARG527 |
| A | ALA535 |
| A | GLY540 |
| A | HOH2491 |
| A | HOH2692 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGR A 1748 |
| Chain | Residue |
| A | ASP155 |
| A | MET157 |
| A | PHE698 |
| A | LYS701 |
| A | HOH2195 |
| A | HOH2693 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGR A 1749 |
| Chain | Residue |
| A | GLY369 |
| A | ARG462 |
| A | PRO474 |
| A | SER476 |
| A | HIS525 |
| A | HOH2716 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGR A 1750 |
| Chain | Residue |
| A | ALA88 |
| A | GLU89 |
| A | SER92 |
| A | GLY451 |
| A | HOH2674 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGR A 1751 |
| Chain | Residue |
| A | TYR103 |
| A | TYR110 |
| A | VAL159 |
| A | LEU411 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGR A 1752 |
| Chain | Residue |
| A | ILE142 |
| A | ASP143 |
| A | LYS186 |
| A | HOH2694 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGR A 1753 |
| Chain | Residue |
| A | ALA259 |
| A | LEU411 |
| A | HOH2152 |
| A | HOH2204 |
| A | HOH2437 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGR A 1754 |
| Chain | Residue |
| A | THR262 |
| A | ASN263 |
| A | LEU282 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGR A 1755 |
| Chain | Residue |
| A | GLY300 |
| A | VAL301 |
| A | ASN318 |
| A | GLY320 |
| A | GLY321 |
| A | HOH2357 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGR A 1756 |
| Chain | Residue |
| A | ARG302 |
| A | ASP304 |
| A | LEU316 |
| A | HIS325 |
| A | HOH2385 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGR A 1757 |
| Chain | Residue |
| A | ASP261 |
| A | ASP454 |
| A | ASN457 |
| A | LYS481 |
| A | HOH2311 |
| A | HOH2442 |
| A | HOH2695 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGR A 1758 |
| Chain | Residue |
| A | ASP281 |
| A | ARG283 |
| A | ARG332 |
| A | THR427 |
| A | HOH2696 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGR A 1759 |
| Chain | Residue |
| A | HIS312 |
| A | ILE329 |
| A | HIS340 |
| A | GLU448 |
| A | GOL1733 |
| A | HOH2697 |
| site_id | DC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGR A 1760 |
| Chain | Residue |
| A | ALA378 |
| A | SER380 |
| A | THR389 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGR A 1761 |
| Chain | Residue |
| A | TYR105 |
| A | THR262 |
| A | LEU411 |
| A | GLU412 |
| A | TYR413 |
| site_id | DC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGR A 1762 |
| Chain | Residue |
| A | ASP433 |
| A | SER440 |
| A | ARG441 |
| A | THR442 |
| site_id | DC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGR A 1763 |
| Chain | Residue |
| A | THR290 |
| A | SER440 |
| A | ARG441 |
| site_id | DC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGR A 1764 |
| Chain | Residue |
| A | MET503 |
| A | ASP504 |
| A | GLN506 |
| A | ILE523 |
| A | PGR1779 |
| A | HOH2516 |
| A | HOH2699 |
| site_id | DC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGR A 1765 |
| Chain | Residue |
| A | ARG447 |
| A | SER508 |
| A | ILE509 |
| A | PGR1779 |
| A | HOH2193 |
| site_id | DC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGR A 1766 |
| Chain | Residue |
| A | PRO568 |
| A | SER569 |
| A | PHE594 |
| A | LYS595 |
| A | GOL1732 |
| A | HOH2567 |
| site_id | DC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGR A 1767 |
| Chain | Residue |
| A | ARG75 |
| A | ASN653 |
| A | ASN684 |
| A | ASN685 |
| A | GLU686 |
| A | HIS720 |
| A | GOL1735 |
| site_id | EC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PGR A 1768 |
| Chain | Residue |
| A | VAL104 |
| A | GLU415 |
| site_id | EC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGR A 1769 |
| Chain | Residue |
| A | ASP304 |
| A | GLN306 |
| A | HOH2393 |
| site_id | EC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGR A 1770 |
| Chain | Residue |
| A | TYR103 |
| A | SER408 |
| A | GLN409 |
| A | HOH2146 |
| A | HOH2159 |
| A | HOH2433 |
| site_id | EC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGR A 1771 |
| Chain | Residue |
| A | ALA17 |
| A | LYS19 |
| A | TRP50 |
| A | HOH2700 |
| A | HOH2701 |
| A | HOH2702 |
| A | HOH2703 |
| site_id | EC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGR A 1772 |
| Chain | Residue |
| A | ARG56 |
| A | ILE62 |
| A | MET693 |
| A | HOH2088 |
| A | HOH2650 |
| site_id | EC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PGR A 1773 |
| Chain | Residue |
| A | ARG295 |
| A | GLU319 |
| site_id | EC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGR A 1774 |
| Chain | Residue |
| A | ARG463 |
| A | PHE464 |
| A | PHE559 |
| A | HOH2704 |
| site_id | EC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGR A 1775 |
| Chain | Residue |
| A | ARG52 |
| A | ASP54 |
| A | PGR1746 |
| A | PGR1780 |
| site_id | EC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGR A 1776 |
| Chain | Residue |
| A | GLY333 |
| A | GLN334 |
| A | LYS445 |
| A | VAL446 |
| A | GLU448 |
| A | HOH2705 |
| site_id | FC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PGR A 1777 |
| Chain | Residue |
| A | GLN657 |
| A | SER699 |
| A | GLU709 |
| A | SER710 |
| A | GLN713 |
| A | PGO1743 |
| A | HOH2614 |
| A | HOH2706 |
| site_id | FC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGR A 1778 |
| Chain | Residue |
| A | ASP32 |
| A | GLY34 |
| A | PRO35 |
| A | ASN249 |
| A | TRP622 |
| A | HOH2707 |
| site_id | FC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGR A 1779 |
| Chain | Residue |
| A | GLN506 |
| A | SER508 |
| A | PGR1764 |
| A | PGR1765 |
| A | PO41793 |
| site_id | FC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGR A 1780 |
| Chain | Residue |
| A | ASP53 |
| A | ASP55 |
| A | PGR1746 |
| A | PGR1775 |
| site_id | FC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGR A 1781 |
| Chain | Residue |
| A | LYS284 |
| A | GLU397 |
| A | PHE432 |
| A | ARG441 |
| site_id | FC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGR A 1782 |
| Chain | Residue |
| A | GLU650 |
| A | ASP683 |
| A | ASN684 |
| A | ASN685 |
| A | HOH2710 |
| site_id | FC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGR A 1783 |
| Chain | Residue |
| A | ASP54 |
| A | ARG56 |
| A | GLU222 |
| A | PRO616 |
| A | TRP668 |
| site_id | FC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGR A 1784 |
| Chain | Residue |
| A | LEU638 |
| A | ASN645 |
| A | VAL646 |
| A | ARG647 |
| A | HOH2711 |
| A | HOH2712 |
| site_id | FC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGR A 1785 |
| Chain | Residue |
| A | ASN66 |
| A | LYS69 |
| A | GLN73 |
| site_id | GC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGR A 1786 |
| Chain | Residue |
| A | LEU342 |
| A | ASP344 |
| A | ALA387 |
| site_id | GC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGR A 1787 |
| Chain | Residue |
| A | ASP281 |
| A | LYS284 |
| A | HIS288 |
| A | GLU292 |
| site_id | GC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGR A 1788 |
| Chain | Residue |
| A | ARG283 |
| A | LYS459 |
| A | VAL460 |
| A | HOH2713 |
| site_id | GC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGR A 1789 |
| Chain | Residue |
| A | GLU246 |
| A | HOH2714 |
| A | HOH2715 |
| site_id | GC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGR A 1790 |
| Chain | Residue |
| A | ALA368 |
| A | LEU532 |
| A | HOH2716 |
| A | HOH2717 |
| site_id | GC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1791 |
| Chain | Residue |
| A | TYR496 |
| A | ARG576 |
| A | SER577 |
| A | HIS697 |
| A | PHE698 |
| A | PO41793 |
| A | HOH2719 |
| A | HOH2720 |
| B | VAL3 |
| B | RGL4 |
| site_id | GC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1792 |
| Chain | Residue |
| A | GLY201 |
| A | LYS220 |
| A | ASP221 |
| A | LEU224 |
| A | HOH2250 |
| site_id | GC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1793 |
| Chain | Residue |
| A | TYR494 |
| A | TYR496 |
| A | LEU501 |
| A | MET503 |
| A | ARG576 |
| A | PGR1779 |
| A | PO41791 |
| site_id | GC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 1794 |
| Chain | Residue |
| A | TRP208 |
| A | HOH2204 |
| A | HOH2309 |
| site_id | HC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1795 |
| Chain | Residue |
| A | ILE91 |
| A | ILE94 |
| A | HOH2131 |
| A | HOH2132 |
| A | HOH2138 |
| site_id | HC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 1796 |
| Chain | Residue |
| A | LYS121 |
| A | HOH2173 |
| A | HOH2194 |
| site_id | HC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 1797 |
| Chain | Residue |
| A | ASP174 |
| A | SER176 |
| A | ASN178 |
| A | VAL180 |
| A | HOH2216 |
| A | HOH2226 |
| site_id | HC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 1798 |
| Chain | Residue |
| A | HIS308 |
| A | HIS312 |
| A | PHE385 |
| site_id | HC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 1799 |
| Chain | Residue |
| A | GLU63 |
| A | ASN66 |
| A | HOH2093 |
| A | HOH2094 |
| site_id | HC6 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR CHAIN B OF RESIDUES 1 TO 4 |
| Chain | Residue |
| A | GLU226 |
| A | SER253 |
| A | TYR496 |
| A | TYR499 |
| A | LEU501 |
| A | SER577 |
| A | ALA578 |
| A | PHE603 |
| A | MET610 |
| A | LEU617 |
| A | GLU621 |
| A | ARG664 |
| A | VAL665 |
| A | HIS697 |
| A | PO41791 |
| A | HOH2266 |
| A | HOH2267 |
| A | HOH2302 |
| A | HOH2303 |
| A | HOH2580 |
| A | HOH2622 |
| A | HOH2678 |
| A | HOH2679 |
| A | HOH2680 |
| A | HOH2681 |
Functional Information from PROSITE/UniProt
| site_id | PS00708 |
| Number of Residues | 31 |
| Details | PRO_ENDOPEP_SER Prolyl endopeptidase family serine active site. DfiaAaefLvnaklttpsqlaceGrSaGGLL |
| Chain | Residue | Details |
| A | ASP552-LEU582 | |
