2X7L

Implications of the HIV-1 Rev dimer structure at 3.2A resolution for multimeric binding to the Rev response element

Functional Information from GO Data

Chain	GOid	namespace	contents
M	0003700	molecular_function	DNA-binding transcription factor activity
M	0003723	molecular_function	RNA binding
M	0006355	biological_process	regulation of DNA-templated transcription
M	0006611	biological_process	protein export from nucleus
M	0016032	biological_process	viral process
M	0030430	cellular_component	host cell cytoplasm
M	0042025	cellular_component	host cell nucleus
M	0044196	cellular_component	host cell nucleolus
M	0051028	biological_process	mRNA transport
N	0003700	molecular_function	DNA-binding transcription factor activity
N	0003723	molecular_function	RNA binding
N	0006355	biological_process	regulation of DNA-templated transcription
N	0006611	biological_process	protein export from nucleus
N	0016032	biological_process	viral process
N	0030430	cellular_component	host cell cytoplasm
N	0042025	cellular_component	host cell nucleus
N	0044196	cellular_component	host cell nucleolus
N	0051028	biological_process	mRNA transport
O	0003700	molecular_function	DNA-binding transcription factor activity
O	0003723	molecular_function	RNA binding
O	0006355	biological_process	regulation of DNA-templated transcription
O	0006611	biological_process	protein export from nucleus
O	0016032	biological_process	viral process
O	0030430	cellular_component	host cell cytoplasm
O	0042025	cellular_component	host cell nucleus
O	0044196	cellular_component	host cell nucleolus
O	0051028	biological_process	mRNA transport
P	0003700	molecular_function	DNA-binding transcription factor activity
P	0003723	molecular_function	RNA binding
P	0006355	biological_process	regulation of DNA-templated transcription
P	0006611	biological_process	protein export from nucleus
P	0016032	biological_process	viral process
P	0030430	cellular_component	host cell cytoplasm
P	0042025	cellular_component	host cell nucleus
P	0044196	cellular_component	host cell nucleolus
P	0051028	biological_process	mRNA transport
Q	0003700	molecular_function	DNA-binding transcription factor activity
Q	0003723	molecular_function	RNA binding
Q	0006355	biological_process	regulation of DNA-templated transcription
Q	0006611	biological_process	protein export from nucleus
Q	0016032	biological_process	viral process
Q	0030430	cellular_component	host cell cytoplasm
Q	0042025	cellular_component	host cell nucleus
Q	0044196	cellular_component	host cell nucleolus
Q	0051028	biological_process	mRNA transport
R	0003700	molecular_function	DNA-binding transcription factor activity
R	0003723	molecular_function	RNA binding
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006611	biological_process	protein export from nucleus
R	0016032	biological_process	viral process
R	0030430	cellular_component	host cell cytoplasm
R	0042025	cellular_component	host cell nucleus
R	0044196	cellular_component	host cell nucleolus
R	0051028	biological_process	mRNA transport

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
B	TYR195-HIS201
A	TYR198-HIS204

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Region: {"description":"Homomultimerization","evidences":[{"source":"HAMAP-Rule","id":"MF_04077","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	156
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	96
Details	Motif: {"description":"Nuclear localization signal and RNA-binding (RRE)","evidences":[{"source":"HAMAP-Rule","id":"MF_04077","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	66
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---