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2X7K

The crystal structure of PPIL1 in complex with cyclosporine A suggests a binding mode for SKIP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000398biological_processmRNA splicing, via spliceosome
A0000413biological_processprotein peptidyl-prolyl isomerization
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005681cellular_componentspliceosomal complex
A0006397biological_processmRNA processing
A0006457biological_processprotein folding
A0008380biological_processRNA splicing
A0016018molecular_functioncyclosporin A binding
A0016853molecular_functionisomerase activity
A0071007cellular_componentU2-type catalytic step 2 spliceosome
A0071013cellular_componentcatalytic step 2 spliceosome
A0097718molecular_functiondisordered domain specific binding
A1990403biological_processembryonic brain development
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CD A 1167
ChainResidue
AHIS31
AASP89
ACYS133
AHOH2087
AHOH2190

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CD A 1168
ChainResidue
AGLU26
AHIS87
ACYS133
AHOH2239

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE NA A 1169
ChainResidue
AASP7
AHOH2267

site_idAC4
Number of Residues25
DetailsBINDING SITE FOR CHAIN B OF CYCLOSPORIN A
ChainResidue
AGLU17
AARG55
APHE60
AGLN63
AGLY71
AALA101
AASN102
AGLN111
APHE113
ATRP121
AHIS126
AMET144
AHOH2032
AHOH2033
AHOH2066
AHOH2137
AHOH2161
BHOH2001
BHOH2002
BHOH2003
BHOH2004
BHOH2005
BHOH2006
BHOH2007
BHOH2008

Functional Information from PROSITE/UniProt
site_idPS00170
Number of Residues18
DetailsCSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YngTkFHRIIkdFMiQGG
ChainResidueDetails
ATYR48-GLY65

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:16595688
ChainResidueDetails
AHIS54
ATHR70
AALA99
AGLY109
ATHR119
ALYS125

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER149

218853

PDB entries from 2024-04-24

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