2WG3

Crystal structure of the complex between human hedgehog-interacting protein HIP and desert hedgehog without calcium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007267	biological_process	cell-cell signaling
A	0007275	biological_process	multicellular organism development
B	0007267	biological_process	cell-cell signaling
B	0007275	biological_process	multicellular organism development

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CcCspGweGDfC

Chain	Residue	Details
C	CYS623-CYS634
C	CYS655-CYS666

---

site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CcCspGWegdf....C

Chain	Residue	Details
C	CYS623-CYS634
C	CYS655-CYS666

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19561611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20519495","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WFR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N1Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19561611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20519495","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WFQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WFR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N1Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	54
Details	Domain: {"description":"EGF-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Region: {"description":"Interaction with SHH zinc binding site"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19561611","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1c9u

Chain	Residue	Details
C	HIS352
C	ASP371

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1c9u

Chain	Residue	Details
D	HIS352
D	ASP371

---