2WBS

Crystal structure of the zinc finger domain of Klf4 bound to its target DNA

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1484

Chain	Residue
A	CYS432
A	CYS437
A	HIS450
A	HIS454

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1485

Chain	Residue
A	CYS462
A	CYS465
A	HIS478
A	HIS482

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1486

Chain	Residue
A	CYS407
A	HIS420
A	HIS424
A	CYS402

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 1487

Chain	Residue
A	TRP434
A	ASP435
A	LYS464
A	HOH2079

---

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	23
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CdyagCgktYtksshlkaHlrt..H

Chain	Residue	Details
A	CYS402-HIS424
A	CYS432-HIS454
A	CYS462-HIS482

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Zinc finger: {"description":"C2H2-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Zinc finger: {"description":"C2H2-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	22
Details	Zinc finger: {"description":"C2H2-type 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	31
Details	Region: {"description":"Interaction with target DNA"}

Chain

Residue

Details

---