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2W9C

Ternary complex of Dpo4 bound to N2,N2-dimethyl-deoxyguanosine modified DNA with incoming dTTP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0005737cellular_componentcytoplasm
A0006260biological_processDNA replication
A0006261biological_processDNA-templated DNA replication
A0006281biological_processDNA repair
A0006974biological_processDNA damage response
A0034061molecular_functionDNA polymerase activity
A0042276biological_processerror-prone translesion synthesis
A0046872molecular_functionmetal ion binding
B0000287molecular_functionmagnesium ion binding
B0003677molecular_functionDNA binding
B0003684molecular_functiondamaged DNA binding
B0003887molecular_functionDNA-directed DNA polymerase activity
B0005737cellular_componentcytoplasm
B0006260biological_processDNA replication
B0006261biological_processDNA-templated DNA replication
B0006281biological_processDNA repair
B0006974biological_processDNA damage response
B0034061molecular_functionDNA polymerase activity
B0042276biological_processerror-prone translesion synthesis
B0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 1342
ChainResidue
AASP105
AGLU106
ATTP1345
AHOH2021

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 1343
ChainResidue
AASP7
APHE8
AASP105
ATTP1345

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1344
ChainResidue
AILE186
AHOH2029
AHOH2030
CDOC13
AALA181

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 1342
ChainResidue
BSER103
BASP105
BGLU106
BHOH2015
BHOH2039

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG B 1343
ChainResidue
BASP7
BTTP1345
BHOH2001
BHOH2036
BHOH2037
BHOH2038

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG B 1344
ChainResidue
BALA181
BASP182
BHOH2024
BHOH2025

site_idAC7
Number of Residues16
DetailsBINDING SITE FOR RESIDUE TTP A 1345
ChainResidue
AASP7
APHE8
AASP9
ATYR10
APHE11
ATHR45
AARG51
AALA57
AASP105
ALYS159
AMG1342
AMG1343
AHOH2043
CDOC13
EO2G5
EDG6

site_idAC8
Number of Residues19
DetailsBINDING SITE FOR RESIDUE TTP B 1345
ChainResidue
BASP7
BPHE8
BTYR10
BPHE11
BALA44
BARG51
BALA57
BASP105
BLYS159
BMG1343
BHOH2001
BHOH2036
BHOH2037
BHOH2038
BHOH2039
BHOH2040
DDOC13
FO2G5
FDG6

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE:
ChainResidueDetails
BGLU106

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING:
ChainResidueDetails
BASP7
BASP105

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Substrate discrimination
ChainResidueDetails
BTYR12

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PDB entries from 2024-11-06

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