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2W4Q

Crystal structure of human zinc-binding alcohol dehydrogenase 1 (ZADH1) in ternary complex with NADP and 18beta-glycyrrhetinic acid

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0006629biological_processlipid metabolic process
A0006693biological_processprostaglandin metabolic process
A0008270molecular_functionzinc ion binding
A0016491molecular_functionoxidoreductase activity
A0016628molecular_functionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
A0047522molecular_function15-oxoprostaglandin 13-reductase [NAD(P)+] activity
Functional Information from PDB Data
site_idAC1
Number of Residues35
DetailsBINDING SITE FOR RESIDUE NAP A 1349
ChainResidue
APRO50
AASN231
ACYS253
AGLY254
AILE256
ASER257
ATYR259
APHE287
AVAL289
AMET332
AMET333
ATHR139
AGLY335
AASN337
AGLY339
ACBW1350
AHOH2085
AHOH2171
AHOH2172
AHOH2173
AHOH2174
AHOH2175
AGLY165
AHOH2176
AHOH2177
AHOH2178
AHOH2179
AHOH2181
AHOH2182
AALA166
ACYS167
ACYS187
AGLY188
ALYS192
ATYR208

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE CBW A 1350
ChainResidue
ATYR51
ATYR64
APHE99
ATYR100
ACYS253
AGLY254
AGLN255
ATYR259
ATYR265
ANAP1349
AHOH2058
AHOH2183

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE CBW A 1351
ChainResidue
AARG24
AGLU26
ALYS116
AVAL117
APHE129
AGLU297
AHOH2073
AHOH2184

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 1352
ChainResidue
AASP211
AASN212
AVAL213
AALA214
AHOH2116
AHOH2185
AHOH2186

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1353
ChainResidue
ATHR189
AHIS190
AGLU191
AHOH2187

site_idAC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 A 1354
ChainResidue
AGLU285
AARG286

site_idAC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 A 1355
ChainResidue
AALA214
AARG218

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsBinding site: {}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1guf
ChainResidueDetails
ATHR60

247035

PDB entries from 2026-01-07

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