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2W2V

Rac2 (G12V) in complex with GTPgS

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005635cellular_componentnuclear envelope
A0005737cellular_componentcytoplasm
A0005741cellular_componentmitochondrial outer membrane
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0006935biological_processchemotaxis
A0007015biological_processactin filament organization
A0007163biological_processestablishment or maintenance of cell polarity
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007264biological_processsmall GTPase-mediated signal transduction
A0008283biological_processcell population proliferation
A0008360biological_processregulation of cell shape
A0010310biological_processregulation of hydrogen peroxide metabolic process
A0010592biological_processpositive regulation of lamellipodium assembly
A0010810biological_processregulation of cell-substrate adhesion
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019887molecular_functionprotein kinase regulator activity
A0019901molecular_functionprotein kinase binding
A0030027cellular_componentlamellipodium
A0030031biological_processcell projection assembly
A0030036biological_processactin cytoskeleton organization
A0030670cellular_componentphagocytic vesicle membrane
A0030865biological_processcortical cytoskeleton organization
A0031410cellular_componentcytoplasmic vesicle
A0032956biological_processregulation of actin cytoskeleton organization
A0042129biological_processregulation of T cell proliferation
A0042554biological_processsuperoxide anion generation
A0042995cellular_componentcell projection
A0043020cellular_componentNADPH oxidase complex
A0043131biological_processerythrocyte enucleation
A0043304biological_processregulation of mast cell degranulation
A0045453biological_processbone resorption
A0045730biological_processrespiratory burst
A0060263biological_processregulation of respiratory burst
A0060753biological_processregulation of mast cell chemotaxis
A0070062cellular_componentextracellular exosome
A0070662biological_processmast cell proliferation
A0070668biological_processpositive regulation of mast cell proliferation
A0071593biological_processlymphocyte aggregation
A0090023biological_processpositive regulation of neutrophil chemotaxis
A1902622biological_processregulation of neutrophil migration
A1903955biological_processpositive regulation of protein targeting to mitochondrion
B0000166molecular_functionnucleotide binding
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005635cellular_componentnuclear envelope
B0005737cellular_componentcytoplasm
B0005741cellular_componentmitochondrial outer membrane
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005884cellular_componentactin filament
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006935biological_processchemotaxis
B0007015biological_processactin filament organization
B0007163biological_processestablishment or maintenance of cell polarity
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007264biological_processsmall GTPase-mediated signal transduction
B0008283biological_processcell population proliferation
B0008360biological_processregulation of cell shape
B0010310biological_processregulation of hydrogen peroxide metabolic process
B0010592biological_processpositive regulation of lamellipodium assembly
B0010810biological_processregulation of cell-substrate adhesion
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0019887molecular_functionprotein kinase regulator activity
B0019901molecular_functionprotein kinase binding
B0030027cellular_componentlamellipodium
B0030031biological_processcell projection assembly
B0030036biological_processactin cytoskeleton organization
B0030670cellular_componentphagocytic vesicle membrane
B0030865biological_processcortical cytoskeleton organization
B0031410cellular_componentcytoplasmic vesicle
B0032956biological_processregulation of actin cytoskeleton organization
B0042129biological_processregulation of T cell proliferation
B0042554biological_processsuperoxide anion generation
B0042995cellular_componentcell projection
B0043020cellular_componentNADPH oxidase complex
B0043131biological_processerythrocyte enucleation
B0043304biological_processregulation of mast cell degranulation
B0045453biological_processbone resorption
B0045730biological_processrespiratory burst
B0060263biological_processregulation of respiratory burst
B0060753biological_processregulation of mast cell chemotaxis
B0070062cellular_componentextracellular exosome
B0070662biological_processmast cell proliferation
B0070668biological_processpositive regulation of mast cell proliferation
B0071593biological_processlymphocyte aggregation
B0090023biological_processpositive regulation of neutrophil chemotaxis
B1902622biological_processregulation of neutrophil migration
B1903955biological_processpositive regulation of protein targeting to mitochondrion
C0000166molecular_functionnucleotide binding
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005635cellular_componentnuclear envelope
C0005737cellular_componentcytoplasm
C0005741cellular_componentmitochondrial outer membrane
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0006935biological_processchemotaxis
C0007015biological_processactin filament organization
C0007163biological_processestablishment or maintenance of cell polarity
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007264biological_processsmall GTPase-mediated signal transduction
C0008283biological_processcell population proliferation
C0008360biological_processregulation of cell shape
C0010310biological_processregulation of hydrogen peroxide metabolic process
C0010592biological_processpositive regulation of lamellipodium assembly
C0010810biological_processregulation of cell-substrate adhesion
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0019887molecular_functionprotein kinase regulator activity
C0019901molecular_functionprotein kinase binding
C0030027cellular_componentlamellipodium
C0030031biological_processcell projection assembly
C0030036biological_processactin cytoskeleton organization
C0030670cellular_componentphagocytic vesicle membrane
C0030865biological_processcortical cytoskeleton organization
C0031410cellular_componentcytoplasmic vesicle
C0032956biological_processregulation of actin cytoskeleton organization
C0042129biological_processregulation of T cell proliferation
C0042554biological_processsuperoxide anion generation
C0042995cellular_componentcell projection
C0043020cellular_componentNADPH oxidase complex
C0043131biological_processerythrocyte enucleation
C0043304biological_processregulation of mast cell degranulation
C0045453biological_processbone resorption
C0045730biological_processrespiratory burst
C0060263biological_processregulation of respiratory burst
C0060753biological_processregulation of mast cell chemotaxis
C0070062cellular_componentextracellular exosome
C0070662biological_processmast cell proliferation
C0070668biological_processpositive regulation of mast cell proliferation
C0071593biological_processlymphocyte aggregation
C0090023biological_processpositive regulation of neutrophil chemotaxis
C1902622biological_processregulation of neutrophil migration
C1903955biological_processpositive regulation of protein targeting to mitochondrion
D0000166molecular_functionnucleotide binding
D0003924molecular_functionGTPase activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005635cellular_componentnuclear envelope
D0005737cellular_componentcytoplasm
D0005741cellular_componentmitochondrial outer membrane
D0005789cellular_componentendoplasmic reticulum membrane
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005884cellular_componentactin filament
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0006935biological_processchemotaxis
D0007015biological_processactin filament organization
D0007163biological_processestablishment or maintenance of cell polarity
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007264biological_processsmall GTPase-mediated signal transduction
D0008283biological_processcell population proliferation
D0008360biological_processregulation of cell shape
D0010310biological_processregulation of hydrogen peroxide metabolic process
D0010592biological_processpositive regulation of lamellipodium assembly
D0010810biological_processregulation of cell-substrate adhesion
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0019887molecular_functionprotein kinase regulator activity
D0019901molecular_functionprotein kinase binding
D0030027cellular_componentlamellipodium
D0030031biological_processcell projection assembly
D0030036biological_processactin cytoskeleton organization
D0030670cellular_componentphagocytic vesicle membrane
D0030865biological_processcortical cytoskeleton organization
D0031410cellular_componentcytoplasmic vesicle
D0032956biological_processregulation of actin cytoskeleton organization
D0042129biological_processregulation of T cell proliferation
D0042554biological_processsuperoxide anion generation
D0042995cellular_componentcell projection
D0043020cellular_componentNADPH oxidase complex
D0043131biological_processerythrocyte enucleation
D0043304biological_processregulation of mast cell degranulation
D0045453biological_processbone resorption
D0045730biological_processrespiratory burst
D0060263biological_processregulation of respiratory burst
D0060753biological_processregulation of mast cell chemotaxis
D0070062cellular_componentextracellular exosome
D0070662biological_processmast cell proliferation
D0070668biological_processpositive regulation of mast cell proliferation
D0071593biological_processlymphocyte aggregation
D0090023biological_processpositive regulation of neutrophil chemotaxis
D1902622biological_processregulation of neutrophil migration
D1903955biological_processpositive regulation of protein targeting to mitochondrion
Functional Information from PDB Data
site_idAC1
Number of Residues23
DetailsBINDING SITE FOR RESIDUE GTP A 500
ChainResidue
AASP11
AASP57
ALYS116
AASP118
ALEU119
ASER158
AALA159
ALEU160
AHOH2031
AHOH2155
AHOH2156
AVAL12
AHOH2157
AHOH2158
AHOH2159
AHOH2160
AALA13
AVAL14
AGLY15
ALYS16
ATHR17
ACYS18
AILE33

site_idAC2
Number of Residues23
DetailsBINDING SITE FOR RESIDUE GTP B 500
ChainResidue
BASP11
BALA13
BVAL14
BGLY15
BLYS16
BTHR17
BCYS18
BPHE28
BILE33
BASP57
BTHR58
BLYS116
BASP118
BSER158
BALA159
BLEU160
BHOH2017
BHOH2055
BHOH2127
BHOH2128
BHOH2129
BHOH2130
BHOH2131

site_idAC3
Number of Residues24
DetailsBINDING SITE FOR RESIDUE GTP C 500
ChainResidue
CASP11
CVAL12
CALA13
CVAL14
CGLY15
CLYS16
CTHR17
CCYS18
CILE33
CASP57
CTHR58
CLYS116
CASP118
CLEU119
CSER158
CALA159
CLEU160
CHOH2018
CHOH2048
CHOH2050
CHOH2117
CHOH2118
CHOH2119
CHOH2120

site_idAC4
Number of Residues22
DetailsBINDING SITE FOR RESIDUE GTP D 500
ChainResidue
DASP11
DALA13
DVAL14
DGLY15
DLYS16
DTHR17
DCYS18
DILE33
DASP57
DTHR58
DLYS116
DASP118
DLEU119
DSER158
DALA159
DLEU160
DHOH2012
DHOH2110
DHOH2111
DHOH2112
DHOH2113
DHOH2114

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLY10
DGLY10
DASP57
DTHR115
AASP57
ATHR115
BGLY10
BASP57
BTHR115
CGLY10
CASP57
CTHR115

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: ADP-ribosylasparagine; by botulinum toxin => ECO:0000250
ChainResidueDetails
AASN39
BASN39
CASN39
DASN39

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS147
BLYS147
CLYS147
DLYS147

site_idSWS_FT_FI4
Number of Residues4
DetailsCARBOHYD: O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR32
BTYR32
CTYR32
DTYR32

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN61

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BGLN61

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
CGLN61

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
DGLN61

site_idCSA5
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AALA13

site_idCSA6
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BALA13

site_idCSA7
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
CALA13

site_idCSA8
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
DALA13

237735

PDB entries from 2025-06-18

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