2VWI
Structure of the OSR1 kinase, a hypertension drug target
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG D 1299 |
| Chain | Residue |
| D | GLY150 |
| D | ASN151 |
| D | ASP164 |
| D | ANP1300 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 1293 |
| Chain | Residue |
| B | ASN151 |
| B | ASP164 |
| B | ANP1295 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG C 1293 |
| Chain | Residue |
| C | ANP1294 |
| C | ASN151 |
| C | ASP164 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE AU A 1293 |
| Chain | Residue |
| C | ALA66 |
| C | CYS70 |
| C | GLN142 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ANP A 1294 |
| Chain | Residue |
| A | VAL31 |
| A | MET92 |
| A | LYS93 |
| A | LEU95 |
| A | LEU153 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE AU B 1294 |
| Chain | Residue |
| D | CYS191 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ANP B 1295 |
| Chain | Residue |
| B | GLY24 |
| B | SER25 |
| B | VAL31 |
| B | ALA44 |
| B | LYS46 |
| B | MET92 |
| B | LYS93 |
| B | LEU95 |
| B | ASP146 |
| B | LYS148 |
| B | ASN151 |
| B | LEU153 |
| B | ASP164 |
| B | MG1293 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ANP C 1294 |
| Chain | Residue |
| A | LYS234 |
| C | ILE23 |
| C | VAL31 |
| C | ALA44 |
| C | LYS46 |
| C | MET92 |
| C | LYS93 |
| C | LEU94 |
| C | LEU95 |
| C | LYS148 |
| C | LEU153 |
| C | ASP164 |
| C | MG1293 |
| C | HOH2020 |
| C | HOH2034 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE AU B 1296 |
| Chain | Residue |
| B | CYS191 |
| B | TRP192 |
| site_id | BC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ANP D 1300 |
| Chain | Residue |
| B | LYS234 |
| D | VAL31 |
| D | ALA44 |
| D | LYS46 |
| D | MET92 |
| D | LYS93 |
| D | LEU95 |
| D | LEU153 |
| D | ASP164 |
| D | MG1299 |
| D | HOH2015 |
| D | HOH2090 |
| D | HOH2091 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE AU D 1301 |
| Chain | Residue |
| D | ALA66 |
| D | CYS70 |
| D | GLN142 |
| D | HOH2007 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE AU D 1302 |
| Chain | Residue |
| D | THR28 |
| D | ILE48 |
| D | CYS53 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE AU A 1295 |
| Chain | Residue |
| A | CYS70 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE AU B 1297 |
| Chain | Residue |
| B | ALA66 |
| B | CYS70 |
| B | GLN142 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE AU B 1298 |
| Chain | Residue |
| B | ILE48 |
| B | CYS53 |
| B | LEU171 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE AU C 1295 |
| Chain | Residue |
| C | THR189 |
| C | CYS191 |
| C | TRP192 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE AU C 1296 |
| Chain | Residue |
| C | THR28 |
| C | LYS52 |
| C | CYS53 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE AU A 1296 |
| Chain | Residue |
| A | PRO190 |
| A | CYS191 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGATAVVQaAycapkkek..........VAIK |
| Chain | Residue | Details |
| A | ILE23-LYS46 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"Q9Z1W9","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14707132","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9Z1W9","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by WNK1","evidences":[{"source":"PubMed","id":"16669787","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16832045","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17190791","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21321328","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23386621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29581290","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP146 | |
| A | GLY150 |
| site_id | CSA10 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | THR189 | |
| B | LYS148 | |
| B | ASP146 |
| site_id | CSA11 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| C | THR189 | |
| C | LYS148 | |
| C | ASP146 |
| site_id | CSA12 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| D | THR189 | |
| D | LYS148 | |
| D | ASP146 |
| site_id | CSA13 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASN151 | |
| A | LYS148 | |
| A | ASP146 |
| site_id | CSA14 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASN151 | |
| B | LYS148 | |
| B | ASP146 |
| site_id | CSA15 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| C | ASN151 | |
| C | LYS148 | |
| C | ASP146 |
| site_id | CSA16 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| D | ASN151 | |
| D | LYS148 | |
| D | ASP146 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP146 | |
| B | GLY150 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| C | ASP146 | |
| C | GLY150 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| D | ASP146 | |
| D | GLY150 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | LYS148 | |
| A | ASP146 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | LYS148 | |
| B | ASP146 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| C | LYS148 | |
| C | ASP146 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| D | LYS148 | |
| D | ASP146 |
| site_id | CSA9 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | THR189 | |
| A | LYS148 | |
| A | ASP146 |
