2VWI

Structure of the OSR1 kinase, a hypertension drug target

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 1299

Chain	Residue
D	GLY150
D	ASN151
D	ASP164
D	ANP1300

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 1293

Chain	Residue
B	ASN151
B	ASP164
B	ANP1295

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 1293

Chain	Residue
C	ANP1294
C	ASN151
C	ASP164

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE AU A 1293

Chain	Residue
C	ALA66
C	CYS70
C	GLN142

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ANP A 1294

Chain	Residue
A	VAL31
A	MET92
A	LYS93
A	LEU95
A	LEU153

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE AU B 1294

Chain	Residue
D	CYS191

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ANP B 1295

Chain	Residue
B	GLY24
B	SER25
B	VAL31
B	ALA44
B	LYS46
B	MET92
B	LYS93
B	LEU95
B	ASP146
B	LYS148
B	ASN151
B	LEU153
B	ASP164
B	MG1293

---

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ANP C 1294

Chain	Residue
A	LYS234
C	ILE23
C	VAL31
C	ALA44
C	LYS46
C	MET92
C	LYS93
C	LEU94
C	LEU95
C	LYS148
C	LEU153
C	ASP164
C	MG1293
C	HOH2020
C	HOH2034

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE AU B 1296

Chain	Residue
B	CYS191
B	TRP192

---

site_id	BC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ANP D 1300

Chain	Residue
B	LYS234
D	VAL31
D	ALA44
D	LYS46
D	MET92
D	LYS93
D	LEU95
D	LEU153
D	ASP164
D	MG1299
D	HOH2015
D	HOH2090
D	HOH2091

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE AU D 1301

Chain	Residue
D	ALA66
D	CYS70
D	GLN142
D	HOH2007

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE AU D 1302

Chain	Residue
D	THR28
D	ILE48
D	CYS53

---

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE AU A 1295

Chain	Residue
A	CYS70

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE AU B 1297

Chain	Residue
B	ALA66
B	CYS70
B	GLN142

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE AU B 1298

Chain	Residue
B	ILE48
B	CYS53
B	LEU171

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE AU C 1295

Chain	Residue
C	THR189
C	CYS191
C	TRP192

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE AU C 1296

Chain	Residue
C	THR28
C	LYS52
C	CYS53

---

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE AU A 1296

Chain	Residue
A	PRO190
A	CYS191

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGATAVVQaAycapkkek..........VAIK

Chain	Residue	Details
A	ILE23-LYS46

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ASP146
B	ASP146
C	ASP146
D	ASP146

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE23
B	ILE23
C	ILE23
D	ILE23

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:14707132

Chain	Residue	Details
A	LYS46
B	LYS46
C	LYS46
D	LYS46

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:22223895

Chain	Residue	Details
A	SER2
B	SER2
C	SER2
D	SER2

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by WNK1 => ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:16832045, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:29581290

Chain	Residue	Details
A	THR185
B	THR185
C	THR185
D	THR185

---