2VWI
Structure of the OSR1 kinase, a hypertension drug target
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | ESRF BEAMLINE BM14 |
| Synchrotron site | ESRF |
| Beamline | BM14 |
| Temperature [K] | 101 |
| Detector technology | CCD |
| Collection date | 2006-06-15 |
| Detector | ADSC CCD |
| Spacegroup name | P 21 21 21 |
| Unit cell lengths | 74.130, 99.900, 158.525 |
| Unit cell angles | 90.00, 90.00, 90.00 |
Refinement procedure
| Resolution | 19.940 - 2.150 |
| R-factor | 0.253 |
| Rwork | 0.253 |
| R-free | 0.28700 |
| Structure solution method | SIR |
| Starting model (for MR) | NONE |
| RMSD bond length | 0.006 |
| RMSD bond angle | 0.964 |
| Data reduction software | HKL-2000 |
| Data scaling software | SCALEPACK |
| Phasing software | SOLVE |
| Refinement software | REFMAC (5.2.0005) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 20.000 | 2.230 |
| High resolution limit [Å] | 2.150 | 2.150 |
| Rmerge | 0.060 | 0.300 |
| Number of reflections | 65284 | |
| <I/σ(I)> | 48.6 | 2.8 |
| Completeness [%] | 98.7 | 88.2 |
| Redundancy | 13.6 | 3.9 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 |
