2VSC

Structure of the immunoglobulin-superfamily ectodomain of human CD47

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Functional Information from GO Data

ChainGOidnamespacecontents
A0009986cellular_componentcell surface
A0070062cellular_componentextracellular exosome
A0005887cellular_componentintegral component of plasma membrane
A0005886cellular_componentplasma membrane
A0035579cellular_componentspecific granule membrane
A0070821cellular_componenttertiary granule membrane
A0098632molecular_functioncell-cell adhesion mediator activity
A0086080molecular_functionprotein binding involved in heterotypic cell-cell adhesion
A0070053molecular_functionthrombospondin receptor activity
A0016477biological_processcell migration
A0071346biological_processcellular response to interferon-gamma
A0071347biological_processcellular response to interleukin-1
A0071349biological_processcellular response to interleukin-12
A0030198biological_processextracellular matrix organization
A0007229biological_processintegrin-mediated signaling pathway
A0050900biological_processleukocyte migration
A0035696biological_processmonocyte extravasation
A1905450biological_processnegative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
A0043312biological_processneutrophil degranulation
A0008228biological_processopsonization
A0008284biological_processpositive regulation of cell proliferation
A0022409biological_processpositive regulation of cell-cell adhesion
A0050729biological_processpositive regulation of inflammatory response
A0050766biological_processpositive regulation of phagocytosis
A0051496biological_processpositive regulation of stress fiber assembly
A0050870biological_processpositive regulation of T cell activation
A0032649biological_processregulation of interferon-gamma production
A0032653biological_processregulation of interleukin-10 production
A0032655biological_processregulation of interleukin-12 production
A0032675biological_processregulation of interleukin-6 production
A0045428biological_processregulation of nitric oxide biosynthetic process
A0032680biological_processregulation of tumor necrosis factor production
A0009617biological_processresponse to bacterium
B0009986cellular_componentcell surface
B0070062cellular_componentextracellular exosome
B0005887cellular_componentintegral component of plasma membrane
B0005886cellular_componentplasma membrane
B0035579cellular_componentspecific granule membrane
B0070821cellular_componenttertiary granule membrane
B0098632molecular_functioncell-cell adhesion mediator activity
B0086080molecular_functionprotein binding involved in heterotypic cell-cell adhesion
B0070053molecular_functionthrombospondin receptor activity
B0016477biological_processcell migration
B0071346biological_processcellular response to interferon-gamma
B0071347biological_processcellular response to interleukin-1
B0071349biological_processcellular response to interleukin-12
B0030198biological_processextracellular matrix organization
B0007229biological_processintegrin-mediated signaling pathway
B0050900biological_processleukocyte migration
B0035696biological_processmonocyte extravasation
B1905450biological_processnegative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
B0043312biological_processneutrophil degranulation
B0008228biological_processopsonization
B0008284biological_processpositive regulation of cell proliferation
B0022409biological_processpositive regulation of cell-cell adhesion
B0050729biological_processpositive regulation of inflammatory response
B0050766biological_processpositive regulation of phagocytosis
B0051496biological_processpositive regulation of stress fiber assembly
B0050870biological_processpositive regulation of T cell activation
B0032649biological_processregulation of interferon-gamma production
B0032653biological_processregulation of interleukin-10 production
B0032655biological_processregulation of interleukin-12 production
B0032675biological_processregulation of interleukin-6 production
B0045428biological_processregulation of nitric oxide biosynthetic process
B0032680biological_processregulation of tumor necrosis factor production
B0009617biological_processresponse to bacterium
C0009986cellular_componentcell surface
C0070062cellular_componentextracellular exosome
C0005887cellular_componentintegral component of plasma membrane
C0005886cellular_componentplasma membrane
C0035579cellular_componentspecific granule membrane
C0070821cellular_componenttertiary granule membrane
C0098632molecular_functioncell-cell adhesion mediator activity
C0086080molecular_functionprotein binding involved in heterotypic cell-cell adhesion
C0070053molecular_functionthrombospondin receptor activity
C0016477biological_processcell migration
C0071346biological_processcellular response to interferon-gamma
C0071347biological_processcellular response to interleukin-1
C0071349biological_processcellular response to interleukin-12
C0030198biological_processextracellular matrix organization
C0007229biological_processintegrin-mediated signaling pathway
C0050900biological_processleukocyte migration
C0035696biological_processmonocyte extravasation
C1905450biological_processnegative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
C0043312biological_processneutrophil degranulation
C0008228biological_processopsonization
C0008284biological_processpositive regulation of cell proliferation
C0022409biological_processpositive regulation of cell-cell adhesion
C0050729biological_processpositive regulation of inflammatory response
C0050766biological_processpositive regulation of phagocytosis
C0051496biological_processpositive regulation of stress fiber assembly
C0050870biological_processpositive regulation of T cell activation
C0032649biological_processregulation of interferon-gamma production
C0032653biological_processregulation of interleukin-10 production
C0032655biological_processregulation of interleukin-12 production
C0032675biological_processregulation of interleukin-6 production
C0045428biological_processregulation of nitric oxide biosynthetic process
C0032680biological_processregulation of tumor necrosis factor production
C0009617biological_processresponse to bacterium
D0009986cellular_componentcell surface
D0070062cellular_componentextracellular exosome
D0005887cellular_componentintegral component of plasma membrane
D0005886cellular_componentplasma membrane
D0035579cellular_componentspecific granule membrane
D0070821cellular_componenttertiary granule membrane
D0098632molecular_functioncell-cell adhesion mediator activity
D0086080molecular_functionprotein binding involved in heterotypic cell-cell adhesion
D0070053molecular_functionthrombospondin receptor activity
D0016477biological_processcell migration
D0071346biological_processcellular response to interferon-gamma
D0071347biological_processcellular response to interleukin-1
D0071349biological_processcellular response to interleukin-12
D0030198biological_processextracellular matrix organization
D0007229biological_processintegrin-mediated signaling pathway
D0050900biological_processleukocyte migration
D0035696biological_processmonocyte extravasation
D1905450biological_processnegative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
D0043312biological_processneutrophil degranulation
D0008228biological_processopsonization
D0008284biological_processpositive regulation of cell proliferation
D0022409biological_processpositive regulation of cell-cell adhesion
D0050729biological_processpositive regulation of inflammatory response
D0050766biological_processpositive regulation of phagocytosis
D0051496biological_processpositive regulation of stress fiber assembly
D0050870biological_processpositive regulation of T cell activation
D0032649biological_processregulation of interferon-gamma production
D0032653biological_processregulation of interleukin-10 production
D0032655biological_processregulation of interleukin-12 production
D0032675biological_processregulation of interleukin-6 production
D0045428biological_processregulation of nitric oxide biosynthetic process
D0032680biological_processregulation of tumor necrosis factor production
D0009617biological_processresponse to bacterium
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC16BINDING SITE FOR RESIDUE NAG A1116
ChainResidue
AGLU11
AASN16
AVAL19
AVAL20
AHOH2074
AHOH2075

AC25BINDING SITE FOR RESIDUE NAG A1117
ChainResidue
AASN32
ATHR34
ANAG1118
DLYS56
DSER57

AC34BINDING SITE FOR RESIDUE NAG A1118
ChainResidue
ATHR34
AASN55
ATHR61
ANAG1117

AC42BINDING SITE FOR RESIDUE NAG A1119
ChainResidue
AASN93
BGLU110

AC510BINDING SITE FOR RESIDUE NAG B1116
ChainResidue
BGLU11
BASN16
BVAL19
BVAL20
BHOH2102
BHOH2103
BHOH2104
CVAL25
CTHR26
CHOH2026

AC62BINDING SITE FOR RESIDUE NAG B1117
ChainResidue
AGLU110
BASN93

AC77BINDING SITE FOR RESIDUE NAG C1116
ChainResidue
BLYS75
CGLU11
CASN16
CVAL19
CVAL20
CHOH2022
CHOH2108

AC88BINDING SITE FOR RESIDUE NAG C1117
ChainResidue
AASN27
BGLN31
CASN32
CTHR34
CHOH2109
CHOH2110
CHOH2111
CHOH2113

AC93BINDING SITE FOR RESIDUE NAG C1118
ChainResidue
CTHR34
CASN55
CHOH2114

BC16BINDING SITE FOR RESIDUE NAG C1119
ChainResidue
AARG114
BGLU11
CASN93
CHOH2115
CHOH2116
DGLU110

BC25BINDING SITE FOR RESIDUE NAG D1117
ChainResidue
DGLU11
DASN16
DVAL19
DVAL20
DHOH2043

BC33BINDING SITE FOR RESIDUE NAG D1118
ChainResidue
CGLU11
DASN32
DARG114

BC48BINDING SITE FOR RESIDUE MG A1120
ChainResidue
ALEU101
AHOH2077
AHOH2078
AHOH2079
AHOH2080
AHOH2081
AHOH2082
BLEU101

BC56BINDING SITE FOR RESIDUE MG C1120
ChainResidue
CHOH2119
CHOH2120
CHOH2121
CHOH2122
CHOH2123
CHOH2124

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
PCA_2vsc_A_18PYROGLUTAMIC ACID binding site
ChainResidueligand
ALEU2-LEU3PCA: PYROGLUTAMIC ACID
AASN27PCA: PYROGLUTAMIC ACID
BGLU35PCA: PYROGLUTAMIC ACID
BTHR102-GLY105PCA: PYROGLUTAMIC ACID

NAG_2vsc_A_11168N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
AVAL10-PHE12NAG: N-ACETYL-D-GLUCOSAMINE
AASN16NAG: N-ACETYL-D-GLUCOSAMINE
ATHR18-VAL20NAG: N-ACETYL-D-GLUCOSAMINE
BLEU111NAG: N-ACETYL-D-GLUCOSAMINE

NAG_2vsc_A_11172N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
AASN32NAG: N-ACETYL-D-GLUCOSAMINE
ATHR34NAG: N-ACETYL-D-GLUCOSAMINE

NAG_2vsc_A_11183N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
AASN32NAG: N-ACETYL-D-GLUCOSAMINE
ATHR34NAG: N-ACETYL-D-GLUCOSAMINE
AASN55NAG: N-ACETYL-D-GLUCOSAMINE

NAG_2vsc_A_11195N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
ALYS43NAG: N-ACETYL-D-GLUCOSAMINE
ATHR91-ASN93NAG: N-ACETYL-D-GLUCOSAMINE
BGLU110NAG: N-ACETYL-D-GLUCOSAMINE

PCA_2vsc_B_17PYROGLUTAMIC ACID binding site
ChainResidueligand
ATHR102-GLY105PCA: PYROGLUTAMIC ACID
BLEU2-LEU3PCA: PYROGLUTAMIC ACID
BASN27PCA: PYROGLUTAMIC ACID

NAG_2vsc_B_11174N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
AGLU110NAG: N-ACETYL-D-GLUCOSAMINE
BTHR91-ASN93NAG: N-ACETYL-D-GLUCOSAMINE

NAG_2vsc_B_11168N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
ALEU111NAG: N-ACETYL-D-GLUCOSAMINE
BVAL10-PHE12NAG: N-ACETYL-D-GLUCOSAMINE
BASN16NAG: N-ACETYL-D-GLUCOSAMINE
BTHR18-VAL20NAG: N-ACETYL-D-GLUCOSAMINE

NAG_2vsc_C_11185N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
BTHR61NAG: N-ACETYL-D-GLUCOSAMINE
CASN32NAG: N-ACETYL-D-GLUCOSAMINE
CTHR34NAG: N-ACETYL-D-GLUCOSAMINE
CGLY52NAG: N-ACETYL-D-GLUCOSAMINE
CASN55NAG: N-ACETYL-D-GLUCOSAMINE

PCA_2vsc_C_17PYROGLUTAMIC ACID binding site
ChainResidueligand
CLEU2-LEU3PCA: PYROGLUTAMIC ACID
CASN27PCA: PYROGLUTAMIC ACID
DGLU35PCA: PYROGLUTAMIC ACID
DARG103-GLY105PCA: PYROGLUTAMIC ACID

NAG_2vsc_C_11168N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
CVAL10-PHE12NAG: N-ACETYL-D-GLUCOSAMINE
CASN16NAG: N-ACETYL-D-GLUCOSAMINE
CTHR18-VAL20NAG: N-ACETYL-D-GLUCOSAMINE
DLEU111NAG: N-ACETYL-D-GLUCOSAMINE

NAG_2vsc_C_11174N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
CGLN31-THR34NAG: N-ACETYL-D-GLUCOSAMINE

PCA_2vsc_D_18PYROGLUTAMIC ACID binding site
ChainResidueligand
CGLU35PCA: PYROGLUTAMIC ACID
CTHR102-GLY105PCA: PYROGLUTAMIC ACID
DLEU2-LEU3PCA: PYROGLUTAMIC ACID
DASN27PCA: PYROGLUTAMIC ACID

NAG_2vsc_C_11193N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
CASN93NAG: N-ACETYL-D-GLUCOSAMINE
DILE108NAG: N-ACETYL-D-GLUCOSAMINE
DGLU110NAG: N-ACETYL-D-GLUCOSAMINE

NAG_2vsc_D_11178N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
CLEU111NAG: N-ACETYL-D-GLUCOSAMINE
DVAL10-PHE12NAG: N-ACETYL-D-GLUCOSAMINE
DASN16NAG: N-ACETYL-D-GLUCOSAMINE
DTHR18-VAL20NAG: N-ACETYL-D-GLUCOSAMINE

NAG_2vsc_D_11184N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
DGLN31-ASN32NAG: N-ACETYL-D-GLUCOSAMINE
DTHR34NAG: N-ACETYL-D-GLUCOSAMINE
DLEU74NAG: N-ACETYL-D-GLUCOSAMINE

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails