2VDY
Crystal structure of the reactive loop cleaved Corticosteroid Binding Globulin complexed with Cortisol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| A | 0005496 | molecular_function | steroid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006704 | biological_process | glucocorticoid biosynthetic process |
| A | 0008289 | molecular_function | lipid binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0140104 | molecular_function | molecular carrier activity |
| B | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| B | 0005496 | molecular_function | steroid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006704 | biological_process | glucocorticoid biosynthetic process |
| B | 0008289 | molecular_function | lipid binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0140104 | molecular_function | molecular carrier activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE HCY A1384 |
| Chain | Residue |
| A | SER19 |
| A | GLN232 |
| A | ILE263 |
| A | ASN264 |
| A | SER267 |
| A | HIS368 |
| A | TRP371 |
| A | HOH2109 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE HCY B1384 |
| Chain | Residue |
| B | GLN232 |
| B | ARG260 |
| B | ASN264 |
| B | SER267 |
| B | HIS368 |
| B | TRP371 |
| B | SER19 |
Functional Information from PROSITE/UniProt
| site_id | PS00284 |
| Number of Residues | 11 |
| Details | SERPIN Serpins signature. LRFNQPFIImI |
| Chain | Residue | Details |
| A | LEU355-ILE365 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18513745","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VDY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Conserved cysteine within steroid binding domain"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
