2VDY

Crystal structure of the reactive loop cleaved Corticosteroid Binding Globulin complexed with Cortisol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005496	molecular_function	steroid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0008211	biological_process	glucocorticoid metabolic process
A	0070062	cellular_component	extracellular exosome
B	0004867	molecular_function	serine-type endopeptidase inhibitor activity
B	0005496	molecular_function	steroid binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0008211	biological_process	glucocorticoid metabolic process
B	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE HCY A1384

Chain	Residue
A	SER19
A	GLN232
A	ILE263
A	ASN264
A	SER267
A	HIS368
A	TRP371
A	HOH2109

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE HCY B1384

Chain	Residue
B	GLN232
B	ARG260
B	ASN264
B	SER267
B	HIS368
B	TRP371
B	SER19

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Functional Information from PROSITE/UniProt

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. LRFNQPFIImI

Chain	Residue	Details
A	LEU355-ILE365

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:18513745, ECO:0007744|PDB:2VDY

Chain	Residue	Details
A	GLN232
A	ASN264
A	HIS368
B	GLN232
B	ASN264
B	HIS368

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
A	TRP371
B	TRP371

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Conserved cysteine within steroid binding domain

Chain	Residue	Details
A	CYS228
B	CYS228

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN74
B	ASN74

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN154
B	ASN154

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site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine

Chain	Residue	Details
A	ASN238
B	ASN238

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN308
B	ASN308

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site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952

Chain	Residue	Details
A	ILE347
B	ILE347

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