2V74

Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), in complex with S-adenosyl-homocysteine

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0016274	molecular_function	protein-arginine N-methyltransferase activity
B	0018216	biological_process	peptidyl-arginine methylation
D	0016274	molecular_function	protein-arginine N-methyltransferase activity
D	0018216	biological_process	peptidyl-arginine methylation
F	0016274	molecular_function	protein-arginine N-methyltransferase activity
F	0018216	biological_process	peptidyl-arginine methylation
H	0016274	molecular_function	protein-arginine N-methyltransferase activity
H	0018216	biological_process	peptidyl-arginine methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE SAH B1478

Chain	Residue
B	TYR150
B	LEU199
B	GLU215
B	ALA216
B	GLY241
B	LYS242
B	VAL243
B	GLU244
B	MET269
B	SER272
B	HOH2005
B	PHE151
B	HOH2006
B	HOH2054
B	TYR154
B	GLN160
B	MET163
B	ARG169
B	GLY193
B	CYS194
B	ILE198

---

site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE SAH D1480

Chain	Residue
D	TYR150
D	PHE151
D	TYR154
D	GLN160
D	MET163
D	ARG169
D	GLY193
D	CYS194
D	ILE198
D	LEU199
D	GLU215
D	ALA216
D	GLY241
D	LYS242
D	VAL243
D	GLU244
D	GLU258
D	MET269
D	SER272
D	HOH2004
D	HOH2067

---

site_id	AC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE SAH F1479

Chain	Residue
F	TYR150
F	PHE151
F	TYR154
F	GLN160
F	MET163
F	ARG169
F	GLY193
F	CYS194
F	GLY195
F	ILE198
F	LEU199
F	GLU215
F	ALA216
F	SER217
F	GLY241
F	LYS242
F	VAL243
F	GLU244
F	MET269
F	SER272

---

site_id	AC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE SAH H1478

Chain	Residue
H	PHE151
H	TYR154
H	GLN160
H	MET163
H	ARG169
H	GLY193
H	CYS194
H	ILE198
H	LEU199
H	GLU215
H	ALA216
H	GLY241
H	LYS242
H	VAL243
H	GLU244
H	GLU258
H	MET269
H	SER272
H	HOH2004
H	HOH2008

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	614
Details	Domain: {"description":"SAM-dependent MTase PRMT-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01015","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	132
Details	Region: {"description":"Required for nuclear translocation","evidences":[{"source":"PubMed","id":"30366907","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17882261","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19843527","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q86X55","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1or8

Chain	Residue	Details
B	GLU258
B	GLU267

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1or8

Chain	Residue	Details
D	GLU258
D	GLU267

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1or8

Chain	Residue	Details
F	GLU258
F	GLU267

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1or8

Chain	Residue	Details
H	GLU258
H	GLU267

---