2R3A

Methyltransferase domain of human suppressor of variegation 3-9 homolog 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0008270	molecular_function	zinc ion binding
A	0042054	molecular_function	histone methyltransferase activity
A	0046974	molecular_function	histone H3K9 methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 300

Chain	Residue
A	CYS222
A	CYS287
A	CYS289
A	CYS294

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	CYS80
A	CYS82
A	CYS85
A	CYS90

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 302

Chain	Residue
A	CYS91
A	CYS118
A	CYS122
A	CYS80

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 303

Chain	Residue
A	CYS85
A	CYS118
A	CYS124
A	CYS128

---

site_id	AC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE SAM A 304

Chain	Residue
A	ARG150
A	GLY151
A	TRP152
A	LYS189
A	THR192
A	TYR193
A	HIS216
A	PHE217
A	VAL218
A	ASN219
A	HIS220
A	TYR261
A	VAL286
A	CYS287
A	LYS288
A	CYS289
A	LEU298
A	HOH324
A	HOH415
A	HOH486
A	HOH488
A	HOH490

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site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SER A 305

Chain	Residue
A	THR83
A	ASP84
A	CYS85
A	GLY125
A	CYS128
A	HOH554
A	HOH557

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A

Chain	Residue	Details
A	CYS80
A	ARG150
A	ASN219
A	CYS222
A	CYS287
A	LYS288
A	CYS289
A	CYS294
A	CYS82
A	CYS85
A	CYS90
A	CYS91
A	CYS118
A	CYS122
A	CYS124
A	CYS128

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190

Chain	Residue	Details
A	TYR261

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER270

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER273
A	SER277

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