2R3A

Methyltransferase domain of human suppressor of variegation 3-9 homolog 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0008270	molecular_function	zinc ion binding
A	0042054	molecular_function	histone methyltransferase activity
A	0046974	molecular_function	histone H3K9 methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 300

Chain	Residue
A	CYS222
A	CYS287
A	CYS289
A	CYS294

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	CYS80
A	CYS82
A	CYS85
A	CYS90

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 302

Chain	Residue
A	CYS91
A	CYS118
A	CYS122
A	CYS80

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 303

Chain	Residue
A	CYS85
A	CYS118
A	CYS124
A	CYS128

---

site_id	AC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE SAM A 304

Chain	Residue
A	ARG150
A	GLY151
A	TRP152
A	LYS189
A	THR192
A	TYR193
A	HIS216
A	PHE217
A	VAL218
A	ASN219
A	HIS220
A	TYR261
A	VAL286
A	CYS287
A	LYS288
A	CYS289
A	LEU298
A	HOH324
A	HOH415
A	HOH486
A	HOH488
A	HOH490

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SER A 305

Chain	Residue
A	THR83
A	ASP84
A	CYS85
A	GLY125
A	CYS128
A	HOH554
A	HOH557

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	58
Details	Domain: {"description":"Pre-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00157","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	123
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Domain: {"description":"Post-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00155","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	17
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20084102","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2R3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---