2QHO

Crystal structure of the UBA domain from EDD ubiquitin ligase in complex with ubiquitin

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0043130	molecular_function	ubiquitin binding
D	0043130	molecular_function	ubiquitin binding
F	0043130	molecular_function	ubiquitin binding
H	0043130	molecular_function	ubiquitin binding

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
A	LYS27-ASP52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
A	ARG54
A	ARG72
C	ARG54
C	ARG72
E	ARG54
E	ARG72
G	ARG54
G	ARG72

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site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Essential for function

Chain	Residue	Details
A	HIS68
C	HIS68
E	HIS68
G	HIS68

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P0CG48

Chain	Residue	Details
A	SER65
C	SER65
E	SER65
G	SER65

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: ADP-ribosylglycine => ECO:0000250|UniProtKB:P0CG48

Chain	Residue	Details
A	GLY76
C	GLY76
E	GLY76
G	GLY76

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site_id	SWS_FT_FI5
Number of Residues	28
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48

Chain	Residue	Details
A	LYS6
C	LYS27
C	LYS29
C	LYS33
C	LYS48
C	LYS63
E	LYS6
E	LYS11
E	LYS27
E	LYS29
E	LYS33
A	LYS11
E	LYS48
E	LYS63
G	LYS6
G	LYS11
G	LYS27
G	LYS29
G	LYS33
G	LYS48
G	LYS63
A	LYS27
A	LYS29
A	LYS33
A	LYS48
A	LYS63
C	LYS6
C	LYS11

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site_id	SWS_FT_FI6
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214

Chain	Residue	Details
A	GLY76
C	GLY76
E	GLY76
G	GLY76

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