2QD5
Structure of wild type human ferrochelatase in complex with a lead-porphyrin compound
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PB A 1101 |
| Chain | Residue |
| A | ACY801 |
| A | ACY803 |
| A | PP9901 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PB B 1102 |
| Chain | Residue |
| B | OXY1001 |
| B | PP91105 |
| B | ACY1106 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FES A 501 |
| Chain | Residue |
| A | CYS406 |
| A | CYS411 |
| A | CYS196 |
| A | SER402 |
| A | CYS403 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FES B 502 |
| Chain | Residue |
| B | CYS696 |
| B | SER902 |
| B | CYS903 |
| B | CYS906 |
| B | CYS911 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CHD A 701 |
| Chain | Residue |
| A | MET99 |
| A | ARG115 |
| A | PRO266 |
| A | SER268 |
| A | VAL305 |
| A | GLY306 |
| A | MET308 |
| A | CHD702 |
| A | HOH1176 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CHD A 702 |
| Chain | Residue |
| A | ARG114 |
| A | CHD701 |
| B | ILE603 |
| B | LYS606 |
| B | PHE610 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CHD B 1103 |
| Chain | Residue |
| B | LEU601 |
| B | PRO766 |
| B | SER768 |
| B | VAL805 |
| B | GLY806 |
| B | MET808 |
| B | CHD1104 |
| B | PP91105 |
| B | HOH1108 |
| B | HOH1162 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CHD B 1104 |
| Chain | Residue |
| A | LYS106 |
| A | PHE110 |
| B | LEU601 |
| B | PRO602 |
| B | CHD1103 |
| site_id | AC9 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE PP9 A 901 |
| Chain | Residue |
| A | MET76 |
| A | PHE93 |
| A | LEU98 |
| A | ARG115 |
| A | ILE119 |
| A | SER195 |
| A | SER197 |
| A | HIS263 |
| A | LEU265 |
| A | PRO266 |
| A | ALA336 |
| A | PHE337 |
| A | HIS341 |
| A | ILE342 |
| A | ACY801 |
| A | ACY803 |
| A | PB1101 |
| A | HOH1102 |
| A | HOH1160 |
| site_id | BC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE PP9 B 1105 |
| Chain | Residue |
| B | MET576 |
| B | PHE593 |
| B | LEU598 |
| B | ARG615 |
| B | TYR623 |
| B | TYR691 |
| B | SER697 |
| B | HIS763 |
| B | LEU765 |
| B | PRO766 |
| B | TYR776 |
| B | VAL805 |
| B | ALA836 |
| B | PHE837 |
| B | HIS841 |
| B | ILE842 |
| B | PB1102 |
| B | CHD1103 |
| B | ACY1106 |
| B | HOH1154 |
| B | HOH1159 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE OXY B 1001 |
| Chain | Residue |
| B | PB1102 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 601 |
| Chain | Residue |
| A | PRO277 |
| A | SER281 |
| A | TRP301 |
| A | HOH1131 |
| B | PRO777 |
| B | SER781 |
| B | TRP801 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACY A 801 |
| Chain | Residue |
| A | PP9901 |
| A | PB1101 |
| A | MET76 |
| A | LEU98 |
| A | TYR165 |
| A | TYR191 |
| A | SER197 |
| A | THR198 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACY B 1106 |
| Chain | Residue |
| B | HIS763 |
| B | SER764 |
| B | GLN802 |
| B | SER803 |
| B | LYS804 |
| B | TRP810 |
| B | PB1102 |
| B | PP91105 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY A 803 |
| Chain | Residue |
| A | SER264 |
| A | SER303 |
| A | LYS304 |
| A | TRP310 |
| A | PP9901 |
| A | PB1101 |
Functional Information from PROSITE/UniProt
| site_id | PS00534 |
| Number of Residues | 19 |
| Details | FERROCHELATASE Ferrochelatase signature. ILfSaHSLPmsvv.NrGDp...Y |
| Chain | Residue | Details |
| A | ILE258-TYR276 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"11175906","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17261801","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HRE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11175906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17261801","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HRK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HRC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11175906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HRK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P22315","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P22315","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1hrk |
| Chain | Residue | Details |
| A | GLU343 | |
| A | HIS263 | |
| A | HIS341 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1hrk |
| Chain | Residue | Details |
| B | HIS841 | |
| B | HIS763 | |
| B | GLU843 |
| site_id | MCSA1 |
| Number of Residues | 9 |
| Details | M-CSA 578 |
| Chain | Residue | Details |
| A | MET76 | |
| A | LEU92 | |
| A | LEU98 | |
| A | ARG164 | |
| A | TYR165 | |
| A | HIS263 | metal ligand, proton acceptor |
| A | ASP340 | |
| A | GLU343 | metal ligand, proton acceptor |
| A | GLU347 |
| site_id | MCSA2 |
| Number of Residues | 9 |
| Details | M-CSA 578 |
| Chain | Residue | Details |
| B | MET576 | |
| B | LEU592 | |
| B | LEU598 | |
| B | ARG664 | |
| B | TYR665 | |
| B | HIS763 | metal ligand, proton acceptor |
| B | ASP840 | |
| B | GLU843 | metal ligand, proton acceptor |
| B | GLU847 |
