Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2Q9Q

The crystal structure of full length human GINS complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000228	cellular_component	nuclear chromosome
A	0000727	biological_process	double-strand break repair via break-induced replication
A	0000811	cellular_component	GINS complex
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006268	biological_process	DNA unwinding involved in DNA replication
A	0032993	cellular_component	protein-DNA complex
A	0071162	cellular_component	CMG complex
B	0000727	biological_process	double-strand break repair via break-induced replication
B	0000811	cellular_component	GINS complex
B	0001833	biological_process	inner cell mass cell proliferation
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006268	biological_process	DNA unwinding involved in DNA replication
B	0071162	cellular_component	CMG complex
C	0000811	cellular_component	GINS complex
C	0001833	biological_process	inner cell mass cell proliferation
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0006260	biological_process	DNA replication
C	0006268	biological_process	DNA unwinding involved in DNA replication
C	0071162	cellular_component	CMG complex
C	1902983	biological_process	DNA strand elongation involved in mitotic DNA replication
D	0000811	cellular_component	GINS complex
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0006260	biological_process	DNA replication
D	0006268	biological_process	DNA unwinding involved in DNA replication
D	0071162	cellular_component	CMG complex
D	1902975	biological_process	mitotic DNA replication initiation
E	0000228	cellular_component	nuclear chromosome
E	0000727	biological_process	double-strand break repair via break-induced replication
E	0000811	cellular_component	GINS complex
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006260	biological_process	DNA replication
E	0006261	biological_process	DNA-templated DNA replication
E	0006268	biological_process	DNA unwinding involved in DNA replication
E	0032993	cellular_component	protein-DNA complex
E	0071162	cellular_component	CMG complex
F	0000727	biological_process	double-strand break repair via break-induced replication
F	0000811	cellular_component	GINS complex
F	0001833	biological_process	inner cell mass cell proliferation
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0005737	cellular_component	cytoplasm
F	0006260	biological_process	DNA replication
F	0006261	biological_process	DNA-templated DNA replication
F	0006268	biological_process	DNA unwinding involved in DNA replication
F	0071162	cellular_component	CMG complex
G	0000811	cellular_component	GINS complex
G	0001833	biological_process	inner cell mass cell proliferation
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0006260	biological_process	DNA replication
G	0006268	biological_process	DNA unwinding involved in DNA replication
G	0071162	cellular_component	CMG complex
G	1902983	biological_process	DNA strand elongation involved in mitotic DNA replication
H	0000811	cellular_component	GINS complex
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0006260	biological_process	DNA replication
H	0006268	biological_process	DNA unwinding involved in DNA replication
H	0071162	cellular_component	CMG complex
H	1902975	biological_process	mitotic DNA replication initiation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
B	MET1
F	MET1

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylthreonine; in DNA replication complex GINS protein SLD5, N-terminally processed => ECO:0007744\|PubMed:21406692

Chain	Residue	Details
B	THR2
F	THR2

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692

Chain	Residue	Details
B	SER12
B	SER16
F	SER12
F	SER16

site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS109
E	LYS109

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)