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2Q8E

Specificity and Mechanism of JMJD2A, a Trimethyllysine-Specific Histone Demethylase

Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NI A 501
ChainResidue
AHIS188
AGLU190
AHIS276
AOGA503
AHOH563

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NI B 502
ChainResidue
BHIS188
BGLU190
BHIS276
BOGA504

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 505
ChainResidue
ACYS234
AHIS240
ACYS306
ACYS308

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 506
ChainResidue
BCYS234
BHIS240
BCYS306
BCYS308

site_idAC5
Number of Residues12
DetailsBINDING SITE FOR RESIDUE OGA A 503
ChainResidue
ATYR132
APHE185
AHIS188
AGLU190
ASER196
AASN198
ALYS206
AHIS276
ASER288
ANI501
AHOH563
FM3L36

site_idAC6
Number of Residues13
DetailsBINDING SITE FOR RESIDUE OGA B 504
ChainResidue
BTYR132
BTYR177
BPHE185
BHIS188
BGLU190
BSER196
BASN198
BLYS206
BTRP208
BHIS276
BSER288
BNI502
BHOH583

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsDomain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues332
DetailsDomain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16677698","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16677698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16677698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PDB","id":"5F2W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F32","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F39","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"B2RXH2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 370
ChainResidueDetails
AGLY170hydrogen bond acceptor, steric role
ATYR177hydrogen bond donor, steric role
AHIS188metal ligand
AGLU190attractive charge-charge interaction, hydrogen bond acceptor, metal ligand, steric role
AHIS276metal ligand
ASER288hydrogen bond donor, steric role

site_idMCSA2
Number of Residues6
DetailsM-CSA 370
ChainResidueDetails
BGLY170hydrogen bond acceptor, steric role
BTYR177hydrogen bond donor, steric role
BHIS188metal ligand
BGLU190attractive charge-charge interaction, hydrogen bond acceptor, metal ligand, steric role
BHIS276metal ligand
BSER288hydrogen bond donor, steric role

239803

PDB entries from 2025-08-06

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