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2PVC

DNMT3L recognizes unmethylated histone H3 lysine 4

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000792cellular_componentheterochromatin
A0000794cellular_componentcondensed nuclear chromosome
A0001890biological_processplacenta development
A0003677molecular_functionDNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006346biological_processDNA methylation-dependent heterochromatin formation
A0007141biological_processmale meiosis I
A0007283biological_processspermatogenesis
A0008047molecular_functionenzyme activator activity
A0010468biological_processregulation of gene expression
A0010558biological_processnegative regulation of macromolecule biosynthetic process
A0019899molecular_functionenzyme binding
A0030154biological_processcell differentiation
A0032259biological_processmethylation
A0035098cellular_componentESC/E(Z) complex
A0044726biological_processepigenetic programing of female pronucleus
A0045814biological_processnegative regulation of gene expression, epigenetic
A0046872molecular_functionmetal ion binding
A0048863biological_processstem cell differentiation
A0051718molecular_functionDNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
A0060718biological_processchorionic trophoblast cell differentiation
A0071514biological_processgenomic imprinting
A0090310biological_processnegative regulation of DNA methylation-dependent heterochromatin formation
A0141005biological_processretrotransposon silencing by heterochromatin formation
A0141068biological_processautosome genomic imprinting
A0141196biological_processretrotransposon silencing by piRNA-directed DNA methylation
A1902494cellular_componentcatalytic complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000792cellular_componentheterochromatin
B0000794cellular_componentcondensed nuclear chromosome
B0001890biological_processplacenta development
B0003677molecular_functionDNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006346biological_processDNA methylation-dependent heterochromatin formation
B0007141biological_processmale meiosis I
B0007283biological_processspermatogenesis
B0008047molecular_functionenzyme activator activity
B0010468biological_processregulation of gene expression
B0010558biological_processnegative regulation of macromolecule biosynthetic process
B0019899molecular_functionenzyme binding
B0030154biological_processcell differentiation
B0032259biological_processmethylation
B0035098cellular_componentESC/E(Z) complex
B0044726biological_processepigenetic programing of female pronucleus
B0045814biological_processnegative regulation of gene expression, epigenetic
B0046872molecular_functionmetal ion binding
B0048863biological_processstem cell differentiation
B0051718molecular_functionDNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
B0060718biological_processchorionic trophoblast cell differentiation
B0071514biological_processgenomic imprinting
B0090310biological_processnegative regulation of DNA methylation-dependent heterochromatin formation
B0141005biological_processretrotransposon silencing by heterochromatin formation
B0141068biological_processautosome genomic imprinting
B0141196biological_processretrotransposon silencing by piRNA-directed DNA methylation
B1902494cellular_componentcatalytic complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000792cellular_componentheterochromatin
C0000794cellular_componentcondensed nuclear chromosome
C0001890biological_processplacenta development
C0003677molecular_functionDNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006346biological_processDNA methylation-dependent heterochromatin formation
C0007141biological_processmale meiosis I
C0007283biological_processspermatogenesis
C0008047molecular_functionenzyme activator activity
C0010468biological_processregulation of gene expression
C0010558biological_processnegative regulation of macromolecule biosynthetic process
C0019899molecular_functionenzyme binding
C0030154biological_processcell differentiation
C0032259biological_processmethylation
C0035098cellular_componentESC/E(Z) complex
C0044726biological_processepigenetic programing of female pronucleus
C0045814biological_processnegative regulation of gene expression, epigenetic
C0046872molecular_functionmetal ion binding
C0048863biological_processstem cell differentiation
C0051718molecular_functionDNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
C0060718biological_processchorionic trophoblast cell differentiation
C0071514biological_processgenomic imprinting
C0090310biological_processnegative regulation of DNA methylation-dependent heterochromatin formation
C0141005biological_processretrotransposon silencing by heterochromatin formation
C0141068biological_processautosome genomic imprinting
C0141196biological_processretrotransposon silencing by piRNA-directed DNA methylation
C1902494cellular_componentcatalytic complex
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 602
ChainResidue
ACYS96
AILE98
ACYS99
ACYS118
ACYS121

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 603
ChainResidue
ACYS108
ACYS113
ACYS142
ACYS145

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 601
ChainResidue
ACYS53
ACYS56
ACYS73
ACYS76

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 605
ChainResidue
BCYS96
BCYS99
BCYS118
BCYS121

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 606
ChainResidue
BCYS108
BCYS113
BCYS142
BCYS145

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 604
ChainResidue
BCYS53
BCYS56
BCYS73
BCYS76

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 608
ChainResidue
CCYS96
CCYS99
CCYS118
CCYS121

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 609
ChainResidue
CCYS108
CCYS113
CCYS142
CCYS145

site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 607
ChainResidue
CCYS53
CCYS56
CCYS73
CCYS76

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues90
DetailsZN_FING: GATA-type; atypical => ECO:0000255|PROSITE-ProRule:PRU00865
ChainResidueDetails
BILE52-ASP82
AILE52-ASP82
CILE52-ASP82

site_idSWS_FT_FI2
Number of Residues168
DetailsZN_FING: PHD-type; atypical => ECO:0000255|PROSITE-ProRule:PRU00865
ChainResidueDetails
BGLN93-SER149
AGLN93-SER149
CGLN93-SER149

226707

PDB entries from 2024-10-30

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