2PI0
Crystal Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-B enhancer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0000976 | molecular_function | transcription cis-regulatory region binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0000976 | molecular_function | transcription cis-regulatory region binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PROSITE/UniProt
| site_id | PS00601 |
| Number of Residues | 33 |
| Details | IRF_1 IRF tryptophan pentad repeat DNA-binding domain signature. WvNksrtrFrIPWkHglrqdaqqe.DfgIFQaWA |
| Chain | Residue | Details |
| A | TRP26-ALA58 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 424 |
| Details | DNA_BIND: IRF tryptophan pentad repeat => ECO:0000255|PROSITE-ProRule:PRU00840 |
| Chain | Residue | Details |
| A | LYS5-ASN111 | |
| B | LYS5-ASN111 | |
| C | LYS5-ASN111 | |
| D | LYS5-ASN111 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:23746807 |
| Chain | Residue | Details |
| A | THR3 | |
| A | THR75 | |
| B | THR3 | |
| B | THR75 | |
| C | THR3 | |
| C | THR75 | |
| D | THR3 | |
| D | THR75 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:23746807 |
| Chain | Residue | Details |
| A | SER14 | |
| A | SER97 | |
| B | SER14 | |
| B | SER97 | |
| C | SER14 | |
| C | SER97 | |
| D | SER14 | |
| D | SER97 |
